Gonadorelin Nasal Spray Kit

Gonadorelin is a synthetic peptide hormone analog, chemically a linear decapeptide with a pyroglutamate and a glycinamide end group. In scientific research, it is studied as a model compound for receptor signaling via G-protein-coupled receptors and as a reference standard in analytical work. This compound is offered as a 2 mg freeze-dried kit with nasal spray accessories, exclusively for laboratory and research purposes.

What is Gonadorelin?

Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂Gonadorelin is a decapeptide whose amino acid sequence is identical to that of endogenous gonadotropin-releasing hormone (GnRH). The chain is terminated at the N-terminus by a pyroglutamate residue and at the C-terminus by a glycinamide function. Both modifications protect the molecule from degradation by exopeptidases and, together with the aromatic His-Trp core, determine the spatial orientation required for receptor recognition. This short, fully characterized sequence makes Gonadorelin a widely used model compound in peptide receptor research.

In research models, Gonadorelin binds to the GnRH receptor, a class A G-protein-coupled receptor that is expressed in gonadotropic cell models. In vitro, this binding leads to coupling to G_q/11-proteins, activation of phospholipase C and the formation of inositol triphosphate and diacylglycerol, after which the intracellular calcium concentration rises and protein kinase C is activated. Characteristically, cell models respond differently to pulsatile than to continuous exposure: with sustained receptor occupancy, in vitro desensitization and internalization of the receptor occur. Consequently, Gonadorelin is used as a model compound and reference substance in scientific research.

Research areas

In a laboratory context, Gonadorelin occurs in the following research areas, among others:

• Receptor research into binding, affinity, and selectivity to the GnRH receptor in isolated cell models in vitro.
• Signal transduction study of the G_q/11-phospholipase C pathway and the associated calcium signals in cell culture systems.
• Model studies of receptor desensitization and internalization with pulsatile versus continuous exposure.
• Structure-activity study in which individual residues of the decapeptide are substituted to refine the pharmacophore model.
• Analytical method development and validation (HPLC, LC-MS) using Gonadorelin as the reference standard.
• Stability and solubility studies of short-chain peptides under controlled temperature and pH conditions.

Each of these applications involves controlled laboratory or preclinical model research.

Gonadorelin in our research assortment

Gonadorelin falls under the category of freeze-dried investigational peptides in our range, which are assembled as a complete kit with nasal spray accessories. While Gonadorelin targets a G-protein-coupled peptide receptor with a phospholipase C-mediated pathway, other components within the same product line have been specifically chosen to cover receptor families with an aberrant signaling cascade or enzymatic targets. These compounds share the freeze-dried kit format but differ fundamentally in molecular class, sequence length, and investigated mechanism.

Specifications

Shape, handling and storage

Gonadorelin is supplied as 2 mg freeze-dried lyophilisate in a sealed vial. The kit also contains an ampoule of sterile physiological saline solution and an empty spray bottle. Unlike a solid tablet form, this is a freeze-dried preparation, for which dissolution in an aqueous medium is part of the laboratory preparation.

Store the unopened vial in a cool, dry place, protected from direct light, in the original packaging; after reconstitution, the material should be stored refrigerated at 2–8 °C. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Composition and lab results

The lyophilisate is offered with a controlled purity of ≥ 99% (HPLC). The supplied saline solution is a sterile physiological sodium chloride solution, which serves as an inert aqueous medium in laboratory preparation.

You can find an overview of the available analytical documentation on our lab results pageThe reports are collected centrally there, so that you can incorporate the data into your own research records.

Frequently Asked Questions

To which substance class does Gonadorelin belong?
Gonadorelin is a synthetic decapeptide with a sequence identical to that of endogenous gonadotropin-releasing hormone. It is therefore a peptide and not a small organic molecule.

Which mechanism is studied in research models?
Binding to the GnRH receptor, a class A G protein-coupled receptor. In vitro, this is followed by coupling to G_q/11, activation of phospholipase C and an increase in intracellular calcium concentration.

In what form is the compound supplied?
As 2 mg freeze-dried lyophilisate in a vial, together with an ampoule of sterile physiological saline solution and an empty spray bottle.

How do I store the vial?
Freeze-dried, store in a cool, dry place and protected from light in the original packaging. Once the material has dissolved, it should be stored refrigerated at 2–8 °C.