PT-141 10 mg

PT-141 (Bremelanotide) is a synthetic peptide belonging to the class of melanocortin receptor ligands; chemically, it is a cyclic heptapeptide with an intramolecular lactam bridge. In scientific research, it is studied as a model compound for melanocortin receptor pharmacology and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 10 mg per vial, exclusively for laboratory and research purposes.

What is PT-141?

PT-141 is a cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, systematically designated as N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyll-L-lysine-(2→7)-lactam. The ring is formed by the amide bond between the side chains of the aspartic acid and lysine, thereby fixing the molecule in a fixed spatial conformation; together with the D-configuration of the phenylalanine residue, this makes the peptide less susceptible to degradation by peptidases in vitro than a comparable linear motif. The compound is derived from the endogenous melanocortin peptide α-MSH and contains the conserved His-D-Phe-Arg-Trp core motif, described in the literature as the pharmacophore of this peptide family.

In research models, PT-141 is characterized as an agonist of the melanocortin receptors, a family of G-protein-coupled receptors referred to in the literature as MC1R through MC5R. In cell models expressing these subtypes, the measured response occurs via activation of adenylate cyclase and an increase in intracellular cAMP; this second-messenger response forms the basis for binding and activity determinations in vitro. Because the peptide does not target the subtypes equally, it serves as a comparison ligand in selectivity studies. Consequently, PT-141 is used as a model compound and reference substance within scientific research.

Raziskovalna področja

In a laboratory context, PT-141 occurs in the following research areas, among others:

• Receptor research into G-protein-coupled melanocortin receptors (MC1R to MC5R) and the subtype selectivity of cyclic α-MSH analogues in vitro.
• Signal transduction study in which the cAMP response is monitored in cell lines expressing a melanocortin receptor.
• Structure-activity relationship study into the influence of the lactam bridge and D-phenylalanine substitution on receptor affinity.
• Biophysical modeling of conformation-restricted cyclic peptides and their enzymatic stability.
• Analytical method development and validation (HPLC, LC-MS) using PT-141 as the reference standard.
• Študije stabilnosti in topnosti liofiliziranih peptidov v nadzorovanih pogojih.

Vsaka od teh aplikacij vključuje nadzorovane laboratorijske ali predklinične modelne raziskave.

PT-141 in our research range

PT-141 falls under the category of freeze-dried peptides in vial form within our range. Researchers working with this category frequently combine the compound with other peptides that possess their own biochemical target. While PT-141 focuses on the melanocortin receptor family and the associated cAMP-mediated signal transduction, other components within the same product line have been specifically chosen to cover divergent receptor systems or enzymatic targets. These compounds share the freeze-dried vial format but differ fundamentally in amino acid sequence, molecular class, and investigated mechanism.

Specifikacije

Oblika, ravnanje in shranjevanje

PT-141 is supplied as a freeze-dried powder with a standardized quantity of 10 mg per vial. Unlike a solid tablet form, a lyophilisate is first placed in a suitable solvent; in the dry state, the material is more stable than in dissolved form, which explains why peptides of this type are offered in a freeze-dried form.

Store the unopened vial refrigerated, protected from direct light and moisture, in the original packaging. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Sestava in laboratorijski rezultati

The lyophilisate contains PT-141 with a controlled purity of ≥ 99% (HPLC). The stated 10 mg refers to the peptide content of the vial; the volume of the freeze-dried cake may vary.

Pregled razpoložljive analitične dokumentacije najdete na naši stran z rezultati laboratorijskih preiskavPoročila se tam zbirajo centralno, tako da lahko podatke vključite v lastne raziskovalne evidence.

Pogosto zastavljena vprašanja

To which dust class does PT-141 belong?
PT-141 is a synthetic cyclic heptapeptide belonging to the group of melanocortin receptor ligands, derived from the endogenous peptide α-MSH. It is therefore not a small organic molecule, but a peptide with a defined amino acid sequence.

What role does the lactam bridge play in research?
The amide bond between the side chains of aspartic acid and lysine closes the molecule into a ring. This cyclization fixes the conformation and increases resistance to enzymatic degradation in vitro, making the compound a widely used model in structure-activity research.

V kakšni obliki je dobavljena povezava?
As freeze-dried powder (lyophilisate) of 10 mg in a sealed vial, with a purity of ≥ 99% (HPLC).

Kako shranim vialo?
Refrigerated, protected from light and moisture, and preferably in the original packaging. Avoid repeated temperature changes.