Kit spray nasale PT-141

PT-141 (bremelanotide) is a synthetic peptide belonging to the class of melanocortin receptor ligands, chemically a cyclic heptapeptide analog of α-MSH. In scientific research, it is studied as a model compound for receptor pharmacology at coupled G-protein receptors and as a reference standard in analytical work. This compound is offered as a 10 mg freeze-dried peptide with an accompanying nasal spray kit, exclusively for laboratory and research purposes.

Cos'è il PT-141?

PT-141 (bremelanotide) is a cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, in which a lactam bridge between the aspartate and lysine side chains closes the ring structure. This cyclization fixes the core sequence His-D-Phe-Arg-Trp in a relatively rigid spatial orientation, while D-phenylalanine and N-acetylnorleucine make the compound less susceptible to enzymatic degradation than linear natural α-MSH. It is precisely this combination of conformational stability and a defined pharmacophore that makes PT-141 a widely used model peptide in the study of melanocortin receptor binding.

In research models, PT-141 acts as an agonist of melanocortin receptors, showing the clearest affinity in vitro for the MC3R and MC4R subtypes. These receptors belong to the family of G-protein-coupled receptors; binding in cell models leads to activation of adenylate cyclase and a measurable increase in intracellular cAMP, making the peptide useful as a positive control in reporter systems. Consequently, PT-141 is used as a model compound and reference substance in scientific research.

Aree di ricerca

In ambito di laboratorio, il PT-141 viene utilizzato, tra gli altri, nei seguenti settori di ricerca:

• Receptor research into the melanocortin subtypes MC3R and MC4R and the selectivity of cyclic α-MSH analogues in vitro.
• Signal transduction study of adenylate cyclase activation and cAMP formation in cultured cell lines expressing melanocortin receptors.
• Structure-activity study into the contribution of the lactam bridge and D-amino acids to binding affinity and conformational stability.
• Biophysical modeling studies of the spatial structure of cyclic peptides using circular dichroism and NMR.
• Analytical method development and validation (RP-HPLC, LC-MS) using PT-141 as the reference standard.
• Research into mucosal administration routes and peptide permeation across epithelial barrier models under controlled conditions.

Ciascuna di queste applicazioni prevede ricerche controllate in laboratorio o su modelli preclinici.

PT-141 nella nostra gamma di ricerca

Within our range, PT-141 falls under the category of investigational compounds offered as a freeze-dried peptide with an accompanying nasal spray kit. While PT-141 targets melanocortin receptors and the associated cAMP pathway, other components within the same product line have been specifically chosen to cover divergent receptor families or enzymatic targets. These compounds share the freeze-dried form and the nasal administration format, but differ fundamentally in amino acid sequence, molecular class, and investigated mechanism.

Specifiche

Forma, manipolazione e stoccaggio

PT-141 is supplied as a 10 mg freeze-dried (lyophilized) peptide in a sealed glass vial, together with the corresponding components of the nasal spray kit. Unlike a solid tablet form, the lyophilisate is a powdered preparation that is first dissolved in a laboratory setting before analytical work is possible.

Store the unopened lyophilisate in a cool, dark place at 2–8 °C, protected from direct light and moisture, in the original packaging. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Composizione e risultati di laboratorio

The freeze-dried peptide is supplied with a controlled purity of ≥ 99% (HPLC), determined on the starting material. The stated quantity of 10 mg refers to the peptide in freeze-dried form, as is customary for lyophilized substances.

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Domande frequenti

A quale classe di polveri appartiene la PT-141?
PT-141 is a synthetic cyclic heptapeptide and a structural analog of α-MSH. As such, it belongs to the melanocortin receptor ligands and not to the small organic molecules.

What is studied in research regarding receptor interaction?
In cell models, binding to the melanocortin subtypes MC3R and MC4R and the subsequent activation of adenylate cyclase are investigated, which becomes visible in vitro as an increase in intracellular cAMP.

Why is the cyclical structure relevant?
The lactam bridge between aspartate and lysine fixes the core sequence His-D-Phe-Arg-Trp in a fixed conformation. This makes the compound more stable against enzymatic degradation than the linear natural peptide and thus more reproducible in laboratory work.

How do I store the freeze-dried peptide?
Cool and dark at 2–8 °C, protected from light and moisture, preferably in the original packaging and sealed vial.