Tesamorelin 11mg + Ipamorelin 6mg

Tesamorelin 11 mg + Ipamorelin 6 mg is a combined investigational compound belonging to the class of synthetic peptides, chemically a composition of a 44-amino acid GHRH analog and a pentapeptide secretagogue. Within scientific research, this combination is studied as a model compound for receptor and signal transduction research and as a reference standard in analytical work. This compound is offered as a freeze-dried vial containing a total of 17 mg, exclusively for laboratory and research purposes.

What is Tesamorelin + Ipamorelin?

Tesamorelin (development code TH9507) is a synthetic analog of growth hormone-releasing hormone and consists of the full 44-amino acid sequence GHRH(1–44), with a trans-3-hexenoyl group covalently linked to the N-terminal tyrosine. This acyl modification makes the molecule less susceptible to cleavage by dipeptidylpeptidase-4 (DPP-4). Ipamorelin (development code NNC 26-0161), on the other hand, is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂, composed of partly non-natural and D-amino acids with an amidated C-terminus — a structure that makes it structurally stable.

In research models, both components have their own biochemical target. In vitro, tesamorelin behaves as a full agonist of the GHRH receptor, a class B G-protein-coupled receptor that acts via G_s directs the formation of cyclic AMP. In cell models, ipamorelin binds selectively to the secretagogue receptor GHS-R1a, which via G_q/11 Phospholipase C activates, with the formation of inositol trisphosphate and mobilization of intracellular calcium. Two distinct receptor systems in a single preparation make the combination suitable for research into converging pathways. Consequently, Tesamorelin + Ipamorelin is used as a model compound and reference substance within scientific research.

Research areas

In a laboratory context, Tesamorelin + Ipamorelin occurs in the following research areas, among others:

• Receptor research into the GHRH receptor and cAMP signal transduction in isolated cell models in vitro.
• Binding and selectivity studies at the secretagogue receptor GHS-R1a with respect to other ligands.
• Enzymological research into DPP-4-mediated degradation and the effect of N-terminal acylation.
• Model studies on the convergence of G_s– and G_q/11-coupled pathways in cell culture systems.
• Analytical method development and validation (HPLC, LC-MS) with both components as reference standards.
• Stability and solubility studies of freeze-dried peptide mixtures under controlled conditions.

Each of these applications involves controlled laboratory or preclinical model research.

Tesamorelin + Ipamorelin in our research assortment

Within our range, this vial falls under the category of combined investigational compounds: preparations in which two peptides are combined in a fixed ratio in a single freeze-dried unit. Researchers choose this type when two targets are studied side-by-side in the same model system. Other compound compounds within the same product line are built around entirely different enzymatic or receptor-bound targets; they share the freeze-dried vial form but differ in molecular class and investigated mechanism.

Specifications

Shape, handling and storage

The preparation is supplied as a lyophilized powder in a glass vial, containing 17 mg total: 11 mg Tesamorelin and 6 mg Ipamorelin. Unlike a solid tablet form, a lyophilisate is intended to be placed in a suitable solvent in the laboratory; the material is more stable in a dry state.

Store the vial refrigerated, protected from light and moisture, in the original packaging. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination. Avoid repeated temperature changes and keep the packaging out of reach of unauthorized persons.

Composition and lab results

For this freeze-dried preparation, a controlled purity of ≥ 99% (HPLC) is maintained for the individual peptide components. The relative proportions of the components are also fixed, so that the composition is known during analytical work.

You can find an overview of the available analytical documentation on our lab results pageThe reports are centrally collected there for your own research records.

Frequently Asked Questions

To which class of substances do Tesamorelin and Ipamorelin belong?
Both are synthetic peptides: Tesamorelin an acylated 44-amino acid analog of growth hormone-releasing hormone, Ipamorelin a pentapeptide with D-amino acids.

Why are two receptor systems combined in one preparation?
In research models, the components act on distinct systems: Tesamorelin on the G_s-coupled GHRH receptor via the cAMP pathway, Ipamorelin on the G_q/11-coupled GHS-R1a via phospholipase C. This makes the preparation suitable for mechanistic analysis.

What is the role of the trans-3-hexenoyl group?
This acyl group on the N-terminal tyrosine makes Tesamorelin less susceptible to cleavage by DPP-4 in vitro, allowing it to remain intact longer in model systems than native GHRH(1–44).

How do I store the vial?
Refrigerated, protected from light and moisture, preferably in the original packaging and without temperature fluctuations.