Sermorelin Acetate 10 mg

Sermorelin Acetate is a synthetic polypeptide of the class of GHRH analogs, chemically the acetate salt of a chain of 29 amino acids with a C-terminal amide function. In scientific research, it is studied as a model compound for receptor pharmacology at class B G-protein-coupled receptors and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 10 mg per vial, exclusively for laboratory and research purposes.

What is Sermorelin Acetate?

Sermorelin (hGHRH(1-29)NH₂) corresponds to the N-terminal fragment of the first 29 amino acids of human growth hormone-releasing hormone, an endogenous polypeptide of 44 residues. The sequence reads Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂In the literature, this fragment is considered the shortest part that retains full receptor recognition; the chain folds into an amphipathic alpha-helix whose hydrophobic side forms the contact surface. This combination of a short sequence and an intact binding profile makes the compound a widely used structural model. The acetate acts as a counterion.

In research models, Sermorelin binds to the GHRH receptor (GHRHR), a class B G-protein-coupled receptor. In cell models, that receptor couples via G_s to adenylate cyclase, which in vitro leads to cAMP formation and activation of protein kinase A; this cascade is a standard yardstick in receptor assays. In addition, the compound is a classic substrate for enzymatic work: dipeptidylpeptidase-4 cleaves the N-terminal dipeptide in vitro, after which the remaining fragment exhibits a significantly reduced receptor affinity. Consequently, Sermorelin Acetate is used as a model compound and reference substance within scientific research.

Research areas

In a laboratory context, Sermorelin Acetate occurs in the following research areas, among others:

• Receptor research into the GHRH receptor, including binding studies in isolated cell models in vitro.
• Signal transduction study into G_s-coupled adenylate cyclase activation and cAMP formation in cell culture systems.
• Enzymological investigation of dipeptidylpeptidase-4 and the cleavage of the N-terminal dipeptide in vitro.
• Structure-activity relationship study of C-terminal amide function and individual residues in the amphipathic helix.
• Analytical method development and validation (HPLC, LC-MS) using Sermorelin Acetate as the reference standard.
• Stability and solubility studies of freeze-dried polypeptides under controlled conditions.

Each of these applications involves controlled laboratory or preclinical model research.

Sermorelin Acetate in our research assortment

Sermorelin Acetate falls under the category of freeze-dried peptides in vial form within our product range. Researchers regularly combine the compound with other polypeptides that are studied via their own biochemical target. While Sermorelin Acetate targets a class B G-protein-coupled receptor and the associated cAMP cascade, other components within the same product line have been selected to cover divergent receptor families or enzymatic pathways. These compounds share the freeze-dried vial form but differ in amino acid composition and investigated mechanism.

Specifications

Shape, handling and storage

Sermorelin Acetate is supplied as a freeze-dried powder of 10 mg per vial. The lyophilisate is a white to off-white powder residue at the bottom of the vial. Unlike solid tablet forms, the material in its freeze-dried state is intended to be dissolved in a suitable solvent in a laboratory setup before analytical work takes place.

Store the closed vial in a cool, dark place, protected from light and moisture, in the original packaging. Handle the connection with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Limit temperature fluctuations. Keep the packaging out of reach of unauthorized persons.

Composition and lab results

A controlled purity of ≥ 99% (HPLC) is maintained for this lyophilisate. The vial contains the polypeptide as an acetate salt, without added excipients.

You can find an overview of the available analytical documentation on our lab results pageThe reports are collected centrally there, so that you can incorporate the data into your own research records.

Frequently Asked Questions

To which class of substances does Sermorelin Acetate belong?
Sermorelin Acetate is a synthetic polypeptide of 29 amino acids with a C-terminal amide function, classified as a GHRH analog. It is not a small synthetic molecule but a peptide with a defined amino acid sequence.

Why is dipeptidylpeptidase-4 relevant in research with this compound?
In research models, this enzyme cleaves the N-terminal dipeptide from the chain. The resulting fragment exhibits significantly reduced receptor affinity in vitro, making the compound a widely used reference point in enzymological research.

In what form is the connection supplied?
As a freeze-dried powder of 10 mg in a sealed vial, intended to be dissolved in a suitable solvent in a laboratory setup.

How do I store the vial?
Cool and dark, protected from light and moisture, preferably in the original packaging.