GHRP-6 10mg

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide belonging to the class of growth hormone secretagogues (release-stimulating molecules) and an agonist of the ghrelin receptor (GHSR-1a). In scientific research, the compound is studied as a model compound in receptor binding and signal transduction research around the hypothalamus-pituitary axis. GHRP-6 is offered as a freeze-dried powder (lyophilisate) with a controlled purity of ≥ 99% (HPLC) and is intended exclusively for laboratory and research purposes.

What is GHRP-6?

GHRP-6 is composed of six amino acids with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 and an amidated C-terminus. The compound belongs to the family of growth hormone-releasing peptides (GHRPs), a series of short synthetic peptides originally derived from met-enkephalin analogs that do not exhibit opioid activity. Two D-amino acids (D-Trp and D-Phe) in the sequence increase structural stability against proteolytic degradation, making GHRP-6 a sought-after model for studying peptide conformation and enzymatic robustness.

Mechanistically, GHRP-6 is an agonist of the growth hormone secretagogue receptor type 1a (GHSR-1a), better known as the ghrelin receptor. Research models study how binding to this G-protein-coupled receptor initiates intracellular signaling cascades, including phospholipase-C- and cAMP-mediated pathways. This receptor signaling axis places GHRP-6 in a different mechanistic category from the GHRH analogs (such as sermorelin or tesamorelin), which act via the individual GHRH receptor. It is precisely this difference that makes GHRP-6 interesting as a comparison compound in receptor pharmacological research.

Research areas

GHRP-6 is used in a laboratory context as a model compound in the following research lines, among others:

• Receptor binding study of the ghrelin receptor (GHSR-1a) and subsequent intracellular signal transduction in vitro.
• Model studies of the growth hormone secretagogue pathway and the regulation of the hypothalamic-pituitary axis in preclinical systems.
• Comparative receptor affinity and potency research with related GHRPs and GHRH analogues.
• Research into peptide stability, solubility, and conformational behavior of short synthetic peptides with D-amino acids.
• Analytical method development using GHRP-6 as an HPLC and mass spectrometry reference.
• Studies on cAMP- and phospholipase C-mediated signaling cascades in cell culture models.

GHRP-6 compared with related compounds

In the literature, GHRP-6 is often placed alongside other growth hormone secretagogues that target the same ghrelin receptor but differ in structure and receptor profile. GHRP-2 is the closest related hexapeptide within the same GHRP series and is often investigated together with GHRP-6 in comparative studies. Ipamorelin is a more selective pentapeptide agonist of the ghrelin receptor and serves as a reference for research into receptor selectivity. Hexarelin is a structurally closely related GHRP that regularly functions as a parallel model link. In research into combined signal routes, GHRP-6 is additionally compared against GHRH analogues such as CJC-1295 without DAC set, to map the two complementary receptor axes.

Specifications

Shape, handling and storage

GHRP-6 is supplied as a freeze-dried powder (lyophilisate) in a 10 mg vial. The dry lyophilisate is the most stable: store it refrigerated, protected from light and moisture. For investigational solution, bacteriostatic water is typically used in laboratories; after reconstitution, the solution is stored refrigerated (2–8 °C) and protected from repeated temperature changes. Avoid vigorous shaking and use short pipette steps to limit foaming and peptide loss from the vial wall. Additional background information on the correct preparation and dilution of powdered investigational peptides is available in the knowledge base.

Purity and lab results

GHRP-6 is offered with a controlled purity of ≥ 99%, determined via HPLC. The identity and purity of our investigational compounds are documented; the corresponding certificates of analysis and an overview of the lab results can be consulted on our lab results pageThis ensures that the analytical substantiation remains transparent and traceable for research purposes.

Frequently Asked Questions

What kind of molecule is GHRP-6?
GHRP-6 is a synthetic hexapeptide (six amino acids) of the class of growth hormone secretagogues and acts as an agonist of the ghrelin receptor (GHSR-1a). It is studied exclusively as a model compound in laboratory research.

How does GHRP-6 differ from a GHRH analogue?
GHRP-6 targets the ghrelin receptor (GHSR-1a), whereas GHRH analogues such as sermorelin or tesamorelin act via the separate GHRH receptor. Therefore, in receptor pharmacological research, both axes are often studied side by side.

How is GHRP-6 stored?
The freeze-dried powder is stored chilled, protected from light and moisture. After research reconstitution, the solution is kept chilled (2–8 °C).

What is the purity of this research material?
GHRP-6 is offered with a controlled purity of ≥ 99% (HPLC). See the lab results page for the accompanying documentation.

Want to know more? Read our guide: HGH peptides explained: GHRH analogs, GHRPs, and the difference from real growth hormone.

Intended exclusively for laboratory and research purposes. Not for human or animal consumption, or for medical, diagnostic, therapeutic, or cosmetic use. The buyer is 18+ and confirms the research context. Not a medicine.