GHRP-2 10mg

GHRP-2 (Growth Hormone Releasing Peptide-2), also known as Pralmorelin, is a synthetic hexapeptide (a chain of six amino acids) and an agonist of the ghrelin receptor (GHSR-1a). It belongs to the class of growth hormone secretagogues (GH secretagogues: molecules that activate the release of growth hormone from the pituitary gland in research models) and is used in scientific research as a model compound for the neuroendocrine growth hormone axis. GHRP-2 is offered exclusively for laboratory and research purposes.

What is GHRP-2?

GHRP-2 is one of the early, fully synthetic peptide secretagogues that plays a central role in research into the hypothalamus-pituitary axis. The compound is composed of the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2, in which the non-natural D-amino acids and the modified naphthylalanine residue ensure high stability and strong affinity for the target receptor. Unlike a growth hormone-releasing hormone (GHRH) analog, GHRP-2 acts via the ghrelin receptor GHSR-1a — the same receptor to which the body's own hormone ghrelin binds. Consequently, GHRP-2 is also described in the literature as a ghrelin mimetic: a small molecule that mimics the binding site of a larger, natural signaling molecule.

Due to this receptor selectivity, GHRP-2 is a widely used reference compound in preclinical and analytical work. Researchers employ it to characterize receptor binding, to study signal transduction via the GHSR-1a pathway, and to compare it with new secretagogues. Its relatively short biological half-life and good solubility after reconstitution make it practical to handle in controlled laboratory settings.

Research areas

In the scientific literature, GHRP-2 primarily occurs within the following research contexts:

• Pharmacology of the ghrelin receptor (GHSR-1a): binding affinity, receptor activation, and downstream signaling in cell models.
• Regulation of pulsatile pituitary growth hormone release in preclinical models.
• The growth hormone/IGF-1 signaling axis and the feedback mechanisms that control this axis.
• Neuroendocrine regulation at the interface of the hypothalamus and pituitary, including interactions with endogenous ghrelin.
• Structure-activity relationships (SAR): how D-amino acids and aromatic residues influence the stability and receptor binding of peptide secretagogues.
• Comparative research against other secretagogues and as an analytical reference standard in HPLC and mass spectrometry methods.

GHRP-2 compared with related compounds

GHRP-2 belongs to a broader family of peptide secretagogues that all act via the ghrelin receptor, but differ from one another in structure, potency, and receptor profile. The most closely related is GHRP-6 10mg, the original hexapeptide secretagogue from which this series originated; GHRP-2 is a structurally optimized variant of it. Ipamorelin 10mg is often cited in comparative studies because it is considered more selective for the GH route, while Hexarelin 10mg is a closely related, potent hexapeptide that also targets the GHSR-1a receptor.

In addition to these ghrelin receptor agonists, GHRP-2 is frequently paired with a GHRH analogue in study designs, such as CJC-1295 without DAC 10mgThese two mechanisms—ghrelin receptor versus GHRH receptor—are investigated in the literature as complementary targets on the growth hormone axis. Such comparisons help to map the role of each individual molecule in neuroendocrine signaling more accurately.

Specifications

Shape, handling and storage

GHRP-2 is supplied as sterile freeze-dried powder (lyophilisate) in a 10 mg vial. In freeze-dried form, the peptide is stable; keep the closed vial refrigerated and protected from light and moisture. For use in a research setup, the lyophilisate is dissolved (reconstituted) in a suitable solvent, after which the solution is stored refrigerated and used within a limited period to limit degradation. Work with clean equipment and avoid repeated temperature changes. These handling guidelines apply exclusively to the laboratory context and do not constitute instructions for use in humans or animals.

Purity and lab results

GHRP-2 is offered with a controlled purity of ≥ 99%, determined via HPLC. For a current overview of the available analysis certificates and lab results, please refer to our lab results pageThere you will find the documentation accompanying our range of research connections.

Frequently Asked Questions

What exactly is GHRP-2?
It is a synthetic hexapeptide and agonist of the ghrelin receptor (GHSR-1a), which is being studied in scientific research as a model compound for growth hormone secretagogues.

What is the difference between GHRP-2 and GHRP-6?
Both are hexapeptide secretagogues that act via the same ghrelin receptor; GHRP-2 is a structurally optimized variant. In comparative research, their receptor profiles are compared.

How does GHRP-2 differ from a GHRH analogue?
A GHRH analogue such as CJC-1295 acts via the GHRH receptor, while GHRP-2 acts via the ghrelin receptor GHSR-1a. These two pathways are described in the literature as complementary mechanisms on the growth hormone axis.

How should GHRP-2 be stored?
Store the freeze-dried powder refrigerated, protected from light and moisture. After reconstitution, the solution is stored refrigerated and used within a short period.

Want to know more? Read our guide: HGH peptides explained: GHRH analogs, GHRPs, and the difference from real growth hormone.

Intended exclusively for laboratory and research purposes. Not for human or animal consumption, or for medical, diagnostic, therapeutic, or cosmetic use. The buyer is 18+ and confirms the research context. Not a medicine.