Andarine S4 25mg

Andarine (S-4) is a synthetic, non-steroidal investigational compound in the class of selective androgen receptor modulators (SARMs), chemically an arylpropionamide derivative. Within scientific research, it is studied as a model compound for nuclear receptor pharmacology and as a reference standard in analytical work. This compound is offered as 25 mg tablets, exclusively for laboratory and research purposes.

What is Andarine (S-4)?

Andarine ((2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, development code GTx-007) is a small organic molecule in the arylpropionamide series. The structure combines a chiral, α-hydroxy-substituted propanamide core with a 4-nitro-3-(trifluoromethyl)phenyl group on the amide side and a 4-acetamidophenoxy group on the ether side. Because the compound lacks a steroidal ring system but recognizes the ligand-binding domain of the androgen receptor, it is a widely used model in the study of non-steroidal ligand-receptor recognition.

In research models, Andarine is described as a partial agonist of the androgen receptor: after binding to the ligand-binding domain, a conformational change is observed in cell models that influences translocation to the nucleus and the subsequent recruitment of co-activators. In vitro, the compound exhibits a different activation profile than steroidal ligands, making it useful for comparative receptor research. Consequently, Andarine (S-4) is used as a model compound and reference substance within scientific research.

Research areas

In a laboratory context, Andarine (S-4) occurs in the following research areas, among others:

• Receptor binding study of the affinity of non-steroidal ligands for the ligand-binding domain of the androgen receptor in vitro.
• Molecular biological model studies of nuclear translocation, co-activator recruitment, and transcriptional activation in transfected cell culture systems.
• Structure-activity relationship study within the arylpropionamide series, comparing the contribution of the nitro-, trifluoromethyl-, and acetamido substituents.
• Enzymological and metabolic modeling research into phase I and phase II turnovers, including hydroxylation, O-dephenylisation, and glucuronidation, in liver microsomal systems.
• Analytical method development and validation (HPLC, LC-MS/MS) using Andarine and its metabolites as the reference standard.
• Stability and solubility studies of fluorinated, nitro-substituted small molecules under controlled conditions.

Each of these applications involves controlled laboratory or preclinical model research.

Andarine (S-4) in our research assortment

Andarine (S-4) falls under the category of oral investigation compounds in solid tablet form within our range. Researchers working with this category frequently combine the compound with other small molecules that are studied via their own biochemical targets. While Andarine focuses on the modulation of a nuclear hormone receptor, other components within the same product line have been specifically chosen to cover enzymatic or membrane-bound targets of a completely different nature. These compounds share the oral tablet form but differ fundamentally in molecular class and investigated mechanism.

Specifications

Shape, handling and storage

Andarine (S-4) is supplied as solid tablets with a standardized amount of 25 mg per tablet, packed in units of 100. Unlike freeze-dried peptides, this solid form does not require reconstitution; the tablets can be weighed directly in a laboratory setup or, if necessary, dissolved in a suitable organic solvent for further analysis.

Store the tablets in a cool, dry place, protected from direct sunlight and moisture, in the original packaging. Observe the usual laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Composition and lab results

For this compound, the content is expressed as the amount of active substance per tablet (25 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations.

You can find an overview of the available analytical documentation on our lab results pageThe reports are collected centrally there, so that you can incorporate the data into your own research records.

Frequently Asked Questions

To which substance class does Andarine (S-4) belong?
Andarine is a small synthetic molecule from the arylpropionamide series and is classified as a non-steroidal selective androgen receptor modulator. It is not a peptide and therefore contains no amino acid sequence.

Which metabolites play a role in the research?
Hydroxylated, O-dephenylized, and glucuronidated conversion products of Andarine are described in liver microsomal model systems. These metabolites are a constant focus in the development and validation of LC-MS/MS methods, in which the parent compound serves as the reference standard.

In what form is the compound supplied?
As 25 mg tablets, packed in units of 100. The solid tablet form requires no reconstitution.

How do I store the tablets?
Cool and dry, protected from direct sunlight and moisture, preferably in the original packaging.