Ipamorelin 10mg

Ipamorelin is a synthetic pentapeptide belonging to the class of growth hormone-releasing peptides (GHRPs) and acts as a selective agonist of the ghrelin receptor (GHSR-1a) in research. It is being studied in preclinical and in vitro models as a model compound for the signaling pathways around the growth hormone axis. Ipamorelin is offered as a freeze-dried powder (lyophilized powder) with a controlled purity of ≥ 99% (HPLC) and is intended exclusively for laboratory and research purposes.

What is Ipamorelin?

Ipamorelin (development code NNC 26-0161) is composed of five amino acids with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2. The molecule was designed as a ghrelin mimetic: it binds to the growth hormone secretagogue receptor (GHSR-1a) and is therefore used in research to model receptor-mediated release of growth hormone (GH) from the pituitary gland. Within the GHRP family, Ipamorelin is considered one of the most selective model compounds because, in research models, it modulates GH release without a significant increase in cortisol, prolactin, or ACTH. This narrow selectivity makes the compound attractive as a reference point in comparative receptor research, where older GHRPs show a broader activation profile.

As a short, defined peptide with an amidated C-terminus and two non-natural residues (Aib and D-2-Nal), Ipamorelin is also well-suited for structure-activity studies and analytical applications, such as calibrating HPLC and mass spectrometry methods for synthetic pentapeptides. The non-natural residues contribute to the metabolic stability of the molecule, making it a useful, reproducible model compound in controlled systems where the presence and signaling pathway of the ghrelin receptor are central.

Research areas

In a laboratory context, Ipamorelin is used in, among other things:

• Receptor binding and activation studies of the ghrelin receptor (GHSR-1a) in vitro
• Model study of the pulsatile release of growth hormone via pituitary cell systems
• Selectivity profile study comparing GH release with cortisol, prolactin, and ACTH response
• Structure-activity relationship (SAR) research of short synthetic peptides with non-natural amino acids
• Research into the proteolytic and solution stability of amidated pentapeptides
• Comparative studies with other GH secretagogues and GHRH analogues within the same signaling pathway

Ipamorelin compared with related compounds

Ipamorelin belongs to the same functional family as GHRP-2 and GHRP-6: all three are ghrelin receptor agonists. In comparative studies, Ipamorelin distinguishes itself by its narrower selectivity, while GHRP-6 shows a clearer effect on appetite-related signaling in models. A second, mechanistically different group consists of the GHRH analogues such as CJC-1295 without DAC (Mod GRF 1-29), which target the GHRH receptor rather than the ghrelin receptor. Because both receptors act on the pituitary gland via separate routes, a GHRP and a GHRH analogue are often studied together in research; that combination is available separately as the premixed CJC-1295 without DAC + Ipamorelin-vial.

Specifications

Shape, handling and storage

Ipamorelin is supplied as a freeze-dried powder in a 10 mg vial. The compound is most stable as a lyophilisate: store the closed vial refrigerated and in the dark, protected from moisture. For research use, the powder is reconstituted with bacteriostatic water; after reconstitution, the solution is stored refrigerated (2–8 °C) and protected from light. Repeated temperature changes and prolonged exposure to room temperature are avoided to maintain peptide integrity. When weighing and resolving, always use clean, calibrated equipment within a controlled laboratory setting.

Purity and lab results

Ipamorelin is offered with a controlled purity of ≥ 99%, determined via HPLC. Analytical documentation and an overview of our lab results can be found on the lab results page.

Frequently Asked Questions

What type of connection is Ipamorelin?
A synthetic pentapeptide that acts in research as a selective agonist of the ghrelin receptor (GHSR-1a), within the class of growth hormone-releasing peptides (GHRPs).

How does Ipamorelin differ from a GHRH analogue?
A GHRH analogue such as CJC-1295 without DAC binds to the GHRH receptor, while Ipamorelin binds to the ghrelin/GHS receptor. These are two separate pathways that converge in the pituitary gland, and are therefore often studied side-by-side in research.

How is the powder in the study prepared?
The lyophilisate is reconstituted in a laboratory setup with bacteriostatic water; the resulting solution is cooled and stored in the dark.

Why is Ipamorelin considered a selective GHRP?
In research models, Ipamorelin modulates growth hormone release without a significant increase in cortisol, prolactin, or ACTH. This narrow activation profile makes it a useful reference point when comparing GH secretagogues.

What is the stated purity?
≥ 99%, determined via HPLC. See the lab results page for the analytical documentation.

Want to know more? Read our guide: HGH peptides explained: GHRH analogs, GHRPs, and the difference from real growth hormone.

Intended exclusively for laboratory and research purposes. Not for human or animal consumption, or for medical, diagnostic, therapeutic, or cosmetic use. The buyer is 18+ and confirms the research context. Not a medicine.