AICAR 10mg

AICAR (Acadesine) is a synthetic nucleoside analog, chemically a ribosylated imidazole-4-carboxamide. In scientific research, it is studied as a model compound for the activation of AMP-activated protein kinase (AMPK) and as a reference standard in analytical work. This compound is offered as 10 mg tablets, exclusively for laboratory and research purposes.

What is AICAR (Acadesine)?

AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is a small organic molecule belonging to the purine nucleoside analogs. Its structure combines a 5-aminoimidazole-4-carboxamide core with a β-D-ribofuranose unit, making the compound structurally very similar to the natural intermediates of purine synthesis. It is precisely this similarity that makes AICAR a widely used model in the study of nucleotide metabolism and nucleotide-regulated kinases.

In research models, AICAR itself serves as the starting compound: the molecule is taken up into the cell via nucleoside transporters and phosphorylated by adenosine kinase into the ribonucleotide ZMP. In vitro, this ZMP mimics the structure of AMP and binds to the γ-subunit of AMPK, thereby allosterically converting the kinase into an active conformation without changing the actual AMP:ATP ratio in the cell. This two-step biotransformation makes the compound interesting for enzymological and signal transduction-oriented laboratory research. Consequently, AICAR is used as a model compound and reference substance within scientific research.

Forschungsgebiete

Im Laborkontext findet AICAR unter anderem in folgenden Forschungsbereichen statt:

• Research into the allosteric activation of AMP-activated protein kinase (AMPK) and the associated downstream phosphorylation cascades in isolated cell models in vitro.
• Enzymological research into the adenosine kinase-mediated conversion of AICAR to the ribonucleotide ZMP.
• Biophysical model studies regarding nucleotide-binding regulatory domains and the structure-activity relationship of imidazole-carboxamide ribosides.
• Model studies of cellular energy sensors and the interaction between AMPK and mTOR signaling in cell culture systems.
• Analytical method development and validation (HPLC, LC-MS) using AICAR as the reference standard.
• Stability and solubility studies of polar nucleoside analogs under controlled conditions.

Jede dieser Anwendungen beinhaltet kontrollierte Labor- oder präklinische Modellforschung.

AICAR innerhalb unseres Forschungsbereichs

Within our product range, AICAR falls under the category of oral investigation compounds in solid tablet form. Researchers working with this category frequently combine the compound with other small molecules that are studied via their own biochemical targets. While AICAR focuses on the nucleotide-mediated activation of an intracellular kinase, other components within the same product line have been specifically chosen to cover divergent enzymatic, nuclear, or receptor-linked targets. These compounds share the oral tablet form but differ fundamentally in molecular class and investigated mechanism.

Spezifikationen

Form, Handhabung und Lagerung

AICAR is supplied as solid tablets with a standardized amount of 10 mg per tablet, packed in quantities of 100. Unlike lyophilized peptides, this solid form does not require reconstitution; the tablets can be weighed directly in a laboratory setup or, as needed, dissolved in a suitable solvent for further analysis. As a polar nucleoside analog, the compound dissolves well in aqueous media, which simplifies working with standard solutions.

Store the tablets in a cool, dry place, protected from direct light and moisture, in the original packaging. Observe the usual laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Zusammensetzung und Laborergebnisse

For this compound, the content is expressed as the amount of active substance per tablet (10 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations.

Eine Übersicht der verfügbaren Analysedokumentation finden Sie auf unserer Website. Seite mit LaborergebnissenDie Berichte werden dort zentral gesammelt, sodass Sie die Daten in Ihre eigenen Forschungsaufzeichnungen einbeziehen können.

Häufig gestellte Fragen

Zu welcher Stoffklasse gehört AICAR?
AICAR is a small synthetic molecule belonging to the class of purine nucleoside analogs. It is not a peptide and therefore contains no amino acid sequence; its structure consists of an imidazole-carboxamide core coupled to a ribose unit.

Welche Rolle spielt ZMP in der Forschung?
In research models, AICAR is phosphorylated by adenosine kinase to the ribonucleotide ZMP. This metabolite mimics the structure of AMP in vitro and is therefore the central focus of mechanistic and enzymological laboratory research into the regulation of AMPK.

In welcher Form wird die Verbindung geliefert?
As 10 mg tablets, packed in units of 100. The solid tablet form requires no reconstitution.

How do I store the tablets?
Cool and dry, protected from direct light and moisture, preferably in the original packaging.