Clenbuterol 40mcg

Clenbuterol is a synthetic small molecule belonging to the group of phenylethanolamines, chemically a chlorinated aminophenylethanolamine with a tert-butylamine group. In scientific research, it is studied as a model compound for receptor activation and signal transduction, and as a reference standard in analytical work. This compound is offered as 40 mcg tablets, exclusively for laboratory and research purposes.

What is Clenbuterol?

Clenbuterol (1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol) possesses the classic ethanolamine side chain characteristic of adrenergic receptor ligands, but the aromatic ring does not have two hydroxyl groups as in natural catecholamines; instead, the ring carries an amino group between two chlorine atoms. It is precisely this substitution that is structurally decisive: without the catechol motif, the compound is no longer a substrate for catechol O-methyltransferase, making it significantly more stable than the endogenous ligands in model systems. For structure-activity research, clenbuterol is therefore an instructive example of how a targeted ring substitution alters the metabolic stability of a ligand class. Furthermore, the two chlorine atoms yield a characteristic isotope pattern in mass spectrometry.

In research models, clenbuterol behaves as a selective agonist of β₂-adrenergic receptor. Activation of this G-protein-coupled receptor leads to a measurable increase in cAMP in cell culture systems, and upon prolonged exposure to receptor desensitization and internalization. These two read terminals make the compound useful for monitoring receptor behavior over time in vitro. Consequently, Clenbuterol is used as a model compound and reference substance in scientific research.

Forskningsområden

In a laboratory context, Clenbuterol occurs in the following research areas, among others:

• Receptor binding research into affinity and selectivity for the β₁-, β₂– and β₃-adrenergic receptor in membrane preparations in vitro.
• Research into signal transduction: cAMP formation via G-protein-coupled pathways in cell culture systems.
• Research into receptor desensitization and internalization upon prolonged exposure in culture.
• Structure-activity study into the influence of ring substitution on the metabolic stability of phenylethanolamines.
• Analytical method development and validation (HPLC, LC-MS) using clenbuterol as the reference standard in residue and screening analysis.
• Research into identification based on the isotope pattern of chlorinated aromatics, and stability studies under controlled conditions.

Var och en av dessa tillämpningar involverar kontrollerad laboratorie- eller preklinisk modellforskning.

Clenbuterol in our research assortment

Clenbuterol falls under the category of oral investigational compounds in solid tablet form within our product range. While clenbuterol activates a G-protein-coupled receptor and serves as a model for long-term receptor occupancy, other components within the same product line have been specifically chosen to cover enzymatic transformations, transport proteins, or nuclear receptors. These compounds share the oral tablet form but differ fundamentally in molecular class and investigated mechanism.

Specifikationer

Form, hantering och förvaring

Clenbuterol is supplied as solid tablets containing a standardized amount of 40 mcg of active substance per tablet, packaged in units of 100. The tablets can be weighed directly in a laboratory setup or placed in a suitable medium for further analysis. Given this low unit amount of active substance, an analytical balance with sufficient resolution is the starting point.

Store the tablets dry at room temperature, protected from direct light and moisture, in the original packaging. Handle the compound with the usual laboratory precautions: work in a clean environment, use suitable personal protective equipment, and prevent cross-contamination with other research materials. This is of particular importance for a compound that is detected at very low concentrations in residue analysis. Keep the packaging out of reach of unauthorized persons.

Sammansättning och labresultat

For this compound, the content is expressed as the amount of active substance per tablet (40 mcg per tablet) instead of as a purity percentage, as is customary for tablet formulations.

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Vanliga frågor

To which class of substances does Clenbuterol belong?
Clenbuterol is a synthetic small molecule from the group of chlorinated phenylethanolamines and functions as a β-agonist in research models.₂-adrenergic receptor. It is not a peptide and therefore contains no amino acid sequence.

Why is the absence of a catechumen motif structurally important?
Natural ligands of adrenergic receptors carry two adjacent hydroxyl groups and are therefore rapidly translocated by catechol-O-methyltransferase. Clenbuterol, instead, has an amino group between two chlorine atoms and is much more stable in model systems, making it suitable for longer exposure durations.

I vilken form levereras föreningen?
As tablets with 40 mcg of active ingredient, packaged per 100 pieces.

How do I store the tablets?
Dry, at room temperature and protected from light and moisture, preferably in the original packaging.