Viala pinealona 20 mg

Pinealon je sintetični kratki peptid iz skupine Khavinsonovih bioregulatorjev, kemijsko tripeptid, sestavljen iz glutaminske kisline, asparaginske kisline in arginina. V znanstvenih raziskavah se preučuje kot modelna spojina za interakcijo med peptidi in nukleinskimi kislinami ter kot referenčni standard pri analitskem delu. Ta spojina je na voljo kot liofiliziran prašek z 20 mg na vialo, izključno za laboratorijske in raziskovalne namene.

What is Pinealon?

Pinealon (L-alpha-glutamyl-L-alpha-aspartyl-L-arginine, zaporedje Glu-Asp-Arg, v literaturi oznaka EDR) je linearni tripeptid z molekulsko formulo C₁₅H₂₆N₆O₈ in molekulsko maso 418,40 Da. Veriga združuje dve kisli stranski verigi — glutaminsko in asparaginsko kislino — z močno bazičnim argininom, zato molekula na zelo kratki razdalji izkazuje tako negativno kot pozitivno gostoto naboja. Zaradi takšne porazdelitve naboja v samo treh aminokislinah je spojina pogosto uporabljen model za interakcijo med kratkimi peptidi in nabitimi biopolimeri.

V raziskovalnih modelih se Pinealon preučuje kot ligand za dvoverižno DNA: spektroskopija in molekulsko modeliranje opisujeta, kako kratki peptidi s to konfiguracijo aminokislin in vitro ciljajo na določena nukleotidna zaporedja v velikem žlebu dvojne vijačnice. V celičnih modelih se nato preučuje, ali je takšna vezava povezana s spremembami v zgoščenosti kromatina — prehodom iz gosto zloženega heterokromatina v dostopnejši evkromatin — in s tem s prepisovanjem določenih genov. Ta delovna hipoteza iz Khavinsonove raziskovalne smeri je bila doslej preučevana predvsem in vitro in v predkliničnih modelih. V znanstvenih raziskavah se Pinealon zato uporablja kot modelna spojina in referenčna snov.

Raziskovalna področja

V laboratorijskem kontekstu se Pinealon med drugim pojavlja na naslednjih raziskovalnih področjih:

• Biophysical research into the binding of short peptides to double-stranded DNA, measured using spectroscopic techniques in vitro.
• Molecular modeling studies of the structure-activity relationship of tripeptides with an acid-base charge profile.
• Epigenetically oriented modeling of chromatin packing and the accessibility of promoter regions.
• Gene expression research in cell culture systems, in which transcript levels are monitored in vitro.
• Analytical method development and validation (HPLC, LC-MS) using Pinealon as the reference standard.
• Stability and solubility studies of freeze-dried tripeptides under controlled conditions.

Vsaka od teh aplikacij vključuje nadzorovane laboratorijske ali predklinične modelne raziskave.

Pinealon in our research assortment

Pinealon falls under the category of freeze-dried peptides in vial form within our range. Researchers in this category regularly combine the compound with other short peptides that are studied via their own biochemical target. While Pinealon focuses on the interaction between a short peptide and nucleic acids, other components in the same product line have been chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried form but differ fundamentally in chain length and investigated mechanism.

Specifikacije

Oblika, ravnanje in shranjevanje

Pinealon is supplied as a freeze-dried powder, standardized to 20 mg per vial. Unlike a solid tablet form, a lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work; the dry state serves the stability of the peptide chain during transport and storage.

Store the unopened vial refrigerated, protected from direct light and moisture, in the original packaging; for longer periods, the dry lyophilisate should be stored frozen. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Sestava in laboratorijski rezultati

This lyophilisate has a controlled purity of ≥ 99% (HPLC), determined on the peptide chain Glu-Asp-Arg. The vial contains exclusively the freeze-dried peptide.

Pregled razpoložljive analitične dokumentacije najdete na naši stran z rezultati laboratorijskih preiskavPoročila se tam zbirajo centralno, tako da lahko podatke vključite v lastne raziskovalne evidence.

Pogosto zastavljena vprašanja

To which class of substances does Pinealon belong?
Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg and belongs to the short peptide bioregulators (cytogens) of the Khavinson research line. It is therefore not a small organic molecule, but an amino acid chain.

What is being investigated regarding the DNA interaction of Pinealon?
In vitro studies using spectroscopy and molecular modeling describe how the EDR motif targets specific nucleotide sequences in the major groove of the double helix. In cell models, the question then is whether this binding is associated with looser chromatin packing and altered transcription — the central focus of mechanistic laboratory research into this connection.

V kakšni obliki je dobavljena spojina?
As a freeze-dried powder of 20 mg per vial. A lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work.

How do I store the bottle?
Refrigerated, protected from light and moisture, preferably in the original packaging.