Súprava na nosový sprej Gonadorelin

Gonadorelin is a synthetic peptide hormone analog, chemically a linear decapeptide with a pyroglutamate and a glycinamide end group. In scientific research, it is studied as a model compound for receptor signaling via G-protein-coupled receptors and as a reference standard in analytical work. This compound is offered as a 2 mg freeze-dried kit with nasal spray accessories, exclusively for laboratory and research purposes.

What is Gonadorelin?

Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂Gonadorelin is a decapeptide whose amino acid sequence is identical to that of endogenous gonadotropin-releasing hormone (GnRH). The chain is terminated at the N-terminus by a pyroglutamate residue and at the C-terminus by a glycinamide function. Both modifications protect the molecule from degradation by exopeptidases and, together with the aromatic His-Trp core, determine the spatial orientation required for receptor recognition. This short, fully characterized sequence makes Gonadorelin a widely used model compound in peptide receptor research.

In research models, Gonadorelin binds to the GnRH receptor, a class A G-protein-coupled receptor that is expressed in gonadotropic cell models. In vitro, this binding leads to coupling to G_q/11-proteins, activation of phospholipase C and the formation of inositol triphosphate and diacylglycerol, after which the intracellular calcium concentration rises and protein kinase C is activated. Characteristically, cell models respond differently to pulsatile than to continuous exposure: with sustained receptor occupancy, in vitro desensitization and internalization of the receptor occur. Consequently, Gonadorelin is used as a model compound and reference substance in scientific research.

Oblasti výskumu

In a laboratory context, Gonadorelin occurs in the following research areas, among others:

• Receptor research into binding, affinity, and selectivity to the GnRH receptor in isolated cell models in vitro.
• Signal transduction study of the G_q/11-phospholipase C pathway and the associated calcium signals in cell culture systems.
• Model studies of receptor desensitization and internalization with pulsatile versus continuous exposure.
• Structure-activity study in which individual residues of the decapeptide are substituted to refine the pharmacophore model.
• Analytical method development and validation (HPLC, LC-MS) using Gonadorelin as the reference standard.
• Stability and solubility studies of short-chain peptides under controlled temperature and pH conditions.

Každá z týchto aplikácií zahŕňa kontrolovaný laboratórny alebo predklinický modelový výskum.

Gonadorelin in our research assortment

Gonadorelin falls under the category of freeze-dried investigational peptides in our range, which are assembled as a complete kit with nasal spray accessories. While Gonadorelin targets a G-protein-coupled peptide receptor with a phospholipase C-mediated pathway, other components within the same product line have been specifically chosen to cover receptor families with an aberrant signaling cascade or enzymatic targets. These compounds share the freeze-dried kit format but differ fundamentally in molecular class, sequence length, and investigated mechanism.

Špecifikácie

Tvar, manipulácia a skladovanie

Gonadorelin is supplied as 2 mg freeze-dried lyophilisate in a sealed vial. The kit also contains an ampoule of sterile physiological saline solution and an empty spray bottle. Unlike a solid tablet form, this is a freeze-dried preparation, for which dissolution in an aqueous medium is part of the laboratory preparation.

Store the unopened vial in a cool, dry place, protected from direct light, in the original packaging; after reconstitution, the material should be stored refrigerated at 2–8 °C. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Zloženie a laboratórne výsledky

The lyophilisate is offered with a controlled purity of ≥ 99% (HPLC). The supplied saline solution is a sterile physiological sodium chloride solution, which serves as an inert aqueous medium in laboratory preparation.

Prehľad dostupnej analytickej dokumentácie nájdete na našej stránka s výsledkami laboratórnych testovSprávy sa tam zhromažďujú centrálne, aby ste mohli údaje zahrnúť do vlastných výskumných záznamov.

Často kladené otázky

To which substance class does Gonadorelin belong?
Gonadorelin is a synthetic decapeptide with a sequence identical to that of endogenous gonadotropin-releasing hormone. It is therefore a peptide and not a small organic molecule.

Which mechanism is studied in research models?
Binding to the GnRH receptor, a class A G protein-coupled receptor. In vitro, this is followed by coupling to G_q/11, activation of phospholipase C and an increase in intracellular calcium concentration.

V akej forme je dodávaná zlúčenina?
As 2 mg freeze-dried lyophilisate in a vial, together with an ampoule of sterile physiological saline solution and an empty spray bottle.

Ako mám skladovať injekčnú liekovku?
Freeze-dried, store in a cool, dry place and protected from light in the original packaging. Once the material has dissolved, it should be stored refrigerated at 2–8 °C.