Súprava na nosový sprej Cortagen

Len na laboratórne a výskumné účely. Nie je určené na humánne ani veterinárne použitie.

Cortagen is a synthetic tetrapeptide from the class of short peptide bioregulators that is studied in controlled laboratory settings within the context of peptide-mediated signaling pathways and molecular regulatory systems. In scientific research, the compound is used as a model compound in analytical work. This compound is offered as a freeze-dried lyophilisate in a sealed 20 mg research vial, supplied as part of a composite research kit.

What is Cortagen?

Cortagen is a tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and proline (Ala-Glu-Asp-Pro, abbreviated as AEDP). The two acidic side chains of glutamic acid and aspartic acid give the molecule a pronounced negative net charge in aqueous media, while the C-terminal proline residue with its pyrrolidine ring restricts the rotational freedom of the peptide chain. This combination of charge distribution and conformational restriction yields a small, sharply defined molecular profile.

In research models, Cortagen is studied within the class of short peptide bioregulators, which are described in the literature as being able to associate with double-stranded DNA in promoter regions in cell culture systems and are thus linked to transcriptional regulatory mechanisms. This target is investigated exclusively in vitro and in preclinical model systems. Consequently, Cortagen is used as a model compound and reference substance within scientific research.

Oblasti výskumu

In a laboratory context, Cortagen occurs in the following research areas, among others:

• Research into peptide-DNA interaction and the complementarity between short amino acid sequences and nucleotide motifs in promoter regions.
• Štúdie peptidmi sprostredkovaných signálnych dráh a molekulárnych regulačných sietí v kontrolovaných bunkových modeloch in vitro.
• Structure-activity relationship research on tetrapeptides and the contribution of individual amino acid residues to charge distribution.
• Conformation and stability study in which the influence of the C-terminal proline residue on the peptide conformation is modeled.
• Analytical method development and validation (HPLC, LC-MS, capillary electrophoresis) using Cortagen as the reference standard.
• Comparative study within the class of short peptide bioregulators under controlled conditions.

Každá z týchto aplikácií zahŕňa kontrolovaný laboratórny alebo predklinický modelový výskum.

Analytická špecifikácia

The material is submitted with a controlled purity of ≥ 99%, determined via high-pressure liquid chromatography (HPLC). Identity and purity are determining parameters in analytical peptide work: in short, highly charged sequences, impurities or degradation products can shift the retention time and thereby influence the interpretation of measurement results. An overview of the available analysis documentation can be found on our stránka s výsledkami laboratórnych testov.

Špecifikácie

Tvar, manipulácia a skladovanie

Cortagen is supplied as freeze-dried lyophilisate in a sealed vial containing 20 mg. The vial is part of a composite research kit which also includes a sterile physiological saline solution (NaCl 0.9%) and an empty spray bottle; reconstitution is applicable to this material. The lyophilization process preserves the molecular integrity of the peptide during storage and transport. The powder is white to off-white and dissolves readily in aqueous media due to the two acidic side chains.

Store the sealed lyophilisate in a cool, dry, and dark place in the original packaging, protected from light and moisture. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, prevent cross-contamination with other research materials, and keep the packaging out of reach of unauthorized persons.

Cortagen in our research assortment

Cortagen falls under the category of freeze-dried investigational compounds in vial form within our range. Researchers working with this category frequently combine the compound with other peptides that are studied via their own molecular target. While Cortagen distinguishes itself through its short, highly charged sequence, other components within the same product line have been specifically chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried vial form but differ fundamentally in molecular class and investigated mechanism.

Často kladené otázky

To which class of substances does Cortagen belong?
Cortagen is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Pro (AEDP) and belongs to the class of short peptide bioregulators.

Why is the sequence relevant in research?
The two acidic side chains and the C-terminal proline residue give the molecule a defined charge distribution and limited conformational freedom. This makes the compound useful as a model in research into peptide-nucleic acid interactions and in analytical methods.

V akej forme je dodávaná zlúčenina?
As freeze-dried lyophilisate in a sealed 20 mg vial, with a purity of ≥ 99% (HPLC), as part of a composite research set.

What does the material look like?
The lyophilisate is white to off-white; the highly charged side chains make the peptide highly soluble in aqueous media.

Ako mám materiál skladovať?
Store in a cool, dry, and dark place in the original packaging, protected from light and moisture.