Fragment de HGH 176-191 5 mg

HGH Fragment 176-191 is a synthetic peptide fragment, chemically a chain of sixteen amino acids corresponding to the C-terminal part of somatotropin. Within scientific research, it is studied as a model compound for receptor and signal transduction research and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 5 mg per vial, exclusively for laboratory and research purposes.

What is HGH Fragment 176-191?

HGH Fragment 176-191, systematically described as somatotropin (176-191), has the sequence Phe-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe. The two cysteine ​​residues at positions 7 and 14 form an intramolecular disulfide bridge, causing the fragment to assume a closed loop that approximates the spatial orientation of the C-terminal part of the parent molecule. This combination of short chain length and fixed conformation makes the compound a workable model for the question of which substructures of a large protein hormone carry which interaction.

In research models, the fragment clearly distinguishes itself from the complete somatotropin molecule: it does not activate the classical growth hormone receptor, and in preclinical models, phosphorylation of STAT5 and induction of IGF-1 are not observed. In vitro, however, the compound is investigated in adipocyte cell models, focusing on signaling via β3-adrenergic receptor subtypes and the associated cAMP/PKA cascade. This decoupling of two signaling pathways within a single parent molecule makes the fragment mechanistically interesting. Consequently, HGH Fragment 176-191 is used as a model compound and reference substance within scientific research.

Domenii de cercetare

In a laboratory context, HGH Fragment 176-191 occurs in the following research areas, among others:

• Receptor research into β3-adrenergic receptor subtypes and the associated cAMP/PKA signaling in isolated cell models in vitro.
• Comparative receptor study of growth hormone receptor failure, measured by STAT5 phosphorylation and IGF-1 induction in preclinical models.
• Structure-activity study into the role of the intramolecular disulfide bridge, in which reduced variants of the fragment serve as a control.
• Model studies in cultured adipocytes (including 3T3-L1 cell culture systems) of lipid metabolism and glycerol release.
• Analytical method development and validation (HPLC, LC-MS, peptide mapping) where the fragment serves as the reference standard.
• Stability and solubility studies of short, cysteine-containing peptides under controlled conditions.

Fiecare dintre aceste aplicații implică cercetare controlată de laborator sau pe modele preclinice.

HGH Fragment 176-191 in our research range

HGH Fragment 176-191 falls under the category of freeze-dried peptides in vials within our range. Researchers in this category regularly combine the compound with other peptides that are studied via their own biochemical target. While this fragment focuses on receptor signaling outside the classical growth hormone pathway, other components within the same product line have been specifically chosen to cover divergent receptor families or enzymatic pathways. These compounds share the freeze-dried form but differ fundamentally in amino acid sequence and investigated mechanism.

Specificații

Formă, manipulare și depozitare

HGH Fragment 176-191 is supplied as a freeze-dried powder with a standardized quantity of 5 mg per vial. As with all lyophilized materials, the material is most stable in the dry state; for analytical work, it is dissolved in a laboratory setup with a suitable solvent. Cysteine-containing peptides are susceptible to oxidation in this process.

Store the vial refrigerated, protected from direct light and moisture, in the original packaging. Observe the usual laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Compoziție și rezultate de laborator

For this compound, a controlled purity of ≥ 99% (HPLC) is maintained, as is customary for freeze-dried peptides serving as reference material.

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Întrebări frecvente

To which class of substances does HGH Fragment 176-191 belong?
It is a synthetic peptide of sixteen amino acids that corresponds to the C-terminal part of somatotropin. Therefore, not a small organic molecule, but a peptide fragment with a fixed sequence.

What is the difference compared to the modified analog AOD-9604?
AOD-9604 is a distinct, modified variant with an extra tyrosine residue at the N-terminus. Both have been studied separately in the literature and are not treated as interchangeable in mechanistic laboratory research.

Why is the disulfide bridge important in research?
The bridge between the two cysteine ​​residues determines the conformation of the fragment. In in vitro structure-activity studies, reduced variants in which that bridge is broken therefore serve as a control.

How do I store the bottle?
Refrigerated, protected from light and moisture, preferably in the original packaging. Freeze-dried, the material is more stable than in solution.