Tamoxifene 20 mg

Tamoxifen is a synthetic small molecule from the group of triphenylethylene derivatives, chemically a (Z)-configured diphenylbutene with a basic ether side chain. In scientific research, it is studied as a model compound for nuclear receptor biochemistry and enzymatic biotransformation, and as a reference standard in analytical work. This compound is offered as 20 mg tablets, exclusively for laboratory and research purposes.

What is Tamoxifen?

Tamoxifen (2-[4-[(Z)-1,2-diphenylbut-1-ene-1-yl]phenoxy]-N,N-dimethylethaneamine) consists of a central, triple-substituted double bond holding together two phenyl rings, an ethyl group, and a phenoxy ring with a dimethylaminoethyl tail. Only the (Z) configuration places the basic side chain in the spatial position active in bonding studies; the (E) form behaves distinctly differently, making the compound a classic example of geometric isomerism with measurable effect. The rigid skeleton combined with a protonable amine makes the substance lipophilic and pH-dependent in solubility, which makes it suitable as a test compound in method development.

In research models, Tamoxifen itself serves as the starting compound: oxidative conversion by cytochrome P450 enzymes, particularly CYP2D6 and CYP3A4, yields the metabolites 4-hydroxytamoxifen and N-desmethyl-4-hydroxytamoxifen (endoxifen) in liver microsome models. These hydroxylated forms exhibit significantly higher receptor affinity in vitro than the parent compound, making the starting compound and metabolite pair a widely used model for enzymological and receptor-directed laboratory research. Consequently, Tamoxifen is used as both a model compound and a reference substance within scientific research.

Aree di ricerca

In a laboratory context, Tamoxifen is found in the following research areas, among others:

• Competitive receptor binding study of the estrogen receptor subtypes ERα and ERβ in vitro.
• Enzymological investigation into the CYP2D6- and CYP3A4-mediated conversion to 4-hydroxytamoxifen and endoxifen in microsome models.
• Structure-activity study within the triphenylethylene series, in which hydroxylation and side chain length are systematically varied.
• Cell culture models in which coregulator recruitment and receptor-dependent gene expression are monitored.
• Analytical method development and validation (HPLC, LC-MS) using Tamoxifen as the calibration substance and system fitness standard.
• Stability and solubility studies of lipophilic, basic small molecules under controlled conditions.

Ciascuna di queste applicazioni prevede ricerche controllate in laboratorio o su modelli preclinici.

Tamoxifen in our investigational range

Tamoxifen falls under the category of oral investigational compounds in solid tablet form within our range. Researchers working with this category regularly place the compound alongside other small molecules that are studied via their own biochemical targets. While Tamoxifen focuses on interaction with a nuclear receptor and its enzymatic conversion, other components within the same product line have been specifically chosen to cover enzyme inhibition or other receptor families. These compounds share the solid tablet form and the standardized amount of active substance per unit, but differ fundamentally in molecular class and the mechanism under investigation.

Specifiche

Forma, manipolazione e stoccaggio

Tamoxifen is supplied as solid tablets with a standardized amount of 20 mg per tablet, packaged in units of 100. The material can be weighed directly in a laboratory setup; for chromatographic or spectroscopic work, it is dissolved in a suitable analytical medium, where the lipophilic core requires an organic medium and the basic side chain makes the solubility pH-dependent.

Store the tablets dry at room temperature, protected from direct light and moisture, in the original packaging. Prolonged exposure to light can promote isomerization around the central double bond in triphenylethylenes; therefore, storage in the dark best preserves the configuration. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Composizione e risultati di laboratorio

For this compound, the content is expressed as the amount of active substance per tablet (20 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations. The relevant specification is therefore the uniform distribution of the active substance across the units.

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Domande frequenti

To which class of substances does Tamoxifen belong?
Tamoxifen is a synthetic small molecule of the triphenylethylene series and is classified as a selective estrogen receptor modulator. It is not a peptide and therefore contains no amino acid sequence.

What is the role of endoxifen in research?
In microsome and cell models, Tamoxifen is converted into 4-hydroxytamoxifen and endoxifen by cytochrome P450 enzymes. These metabolites exhibit higher receptor affinity in vitro than the starting material and are therefore a central focus of enzymological laboratory research, particularly for CYP2D6 variants.

In quale forma viene fornito il composto?
As solid tablets with 20 mg of active substance per tablet, packed in units of 100.

Come conservo le compresse?
Conservare asciutto, a temperatura ambiente e al riparo dalla luce e dall'umidità, preferibilmente nella confezione originale.