Kit spray nasale Selank Amidate

Selank Amidate is a synthetic heptapeptide from the group of tuftsin analogs, chemically an N-terminally acetylated and C-terminally amidated variant of the Selank peptide. In scientific research, it is studied as a model compound for peptide stability and neuropeptide-receptor interaction and as a reference standard in analytical work. This compound is offered as a kit containing 30 mg of freeze-dried peptide material, exclusively for laboratory and research purposes.

What is Selank Amidate?

Selank Amidate (N-acetyl-L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolyl-glycyl-L-proline-amide, sequence Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂is a peptide chain of seven amino acids. The core is the tuftsin sequence Thr-Lys-Pro-Arg, originally described as a fragment of the immunoglobulin G heavy chain, extended with a Pro-Gly-Pro tail. Both ends are chemically shielded: an acetyl group at the N-terminus, an amide function at the C-terminus. This double modification makes the compound a useful model: amino- and carboxypeptidases have less of a hold on it in vitro than on the unprotected starting compound.

In research models, Selank Amidate is primarily studied at the level of peptide-receptor interaction and enzymatic stability. In cell models, the expression of GABA has been examined._A-receptor subunits without direct binding to the benzodiazepine binding site, towards inhibition of enkephalin-degrading enzymes and towards mRNA expression of neurotrophic factors. Because the acetylated and amidated forms remain intact longer in vitro, they compare well with the unprotected peptide. Consequently, Selank Amidate is used as a model compound and reference substance in scientific research.

Aree di ricerca

In a laboratory context, Selank Amidate occurs in the following research areas, among others:

• Research into peptide receptor interaction and GABA expression_A-receptor subunits in isolated cell models in vitro.
• Enzymological research into exopeptidase activity and inhibition of enkephalin-degrading enzymes by short peptides.
• Structure-activity study comparing tuftsine analogs with and without terminal modification.
• Model studies of the mRNA expression of neurotrophic factors in neuronal cell culture systems.
• Analytical method development and validation (HPLC, LC-MS) using Selank Amidate as the reference standard.
• Stability and solubility studies of modified short peptides under controlled conditions.

Ciascuna di queste applicazioni prevede ricerche controllate in laboratorio o su modelli preclinici.

Selank Amidate in our research assortment

Selank Amidate falls under the category of atomizer kits within our range: freeze-dried peptide material supplied as a composite set. Researchers working with this category frequently place the compound alongside other short peptides with their own biochemical target. While Selank Amidate focuses on peptide-receptor interaction and the enzymatic stability of a tuftsin analog, other components within the same product line have been selected to cover divergent receptor families or enzyme systems. They share the kit format and freeze-dried form but differ fundamentally in amino acid sequence and investigated mechanism.

Specifiche

Forma, manipolazione e stoccaggio

Selank Amidate is supplied as 30 mg freeze-dried lyophilisate in a kit containing a sterile sodium chloride solution (0.9%) and an empty spray bottle. This lyophilisate is dissolved prior to analytical work; the material is packed dry and is only processed in the laboratory setup.

Store the freeze-dried material in a cool, dry place in the original packaging, protected from light and moisture; dissolved material should be refrigerated at 2–8 °C. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the kit out of reach of unauthorized persons.

Composizione e risultati di laboratorio

The peptide material in this kit has a controlled purity of ≥ 99% (HPLC). The accompanying sodium chloride solution (0.9%) is a sterile, isotonic saline solution without active ingredients.

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Domande frequenti

To which class of substances does Selank Amidate belong?
It is a synthetic heptapeptide with the tuftsin sequence Thr-Lys-Pro-Arg as its core. It is therefore a peptide, not a small synthetic molecule.

What is the difference compared to the underlying Selank peptide?
The amino acid sequence is the same, but in Selank Amidate, the N-terminus is acetylated and the C-terminus is amidated. This shielding limits attack by exopeptidases in vitro, allowing the compound to remain intact longer.

In quale forma viene fornito il composto?
As lyophilized lyophilisate of 30 mg in a kit with a sterile sodium chloride solution (0.9%) and an empty spray bottle. The lyophilisate is dissolved before analytical work.

How do I store the kit?
The freeze-dried material should be kept cool and dry, protected from light and moisture, in the original packaging. Dissolved material should be kept refrigerated at 2–8 °C.