Tesamorelin

Tesamorelin is a synthetic GHRH analog (growth hormone-releasing hormone analog) comprising the complete 44-amino acid sequence of human GHRH(1-44), provided with a trans-3-hexenoyl group at the N-terminus. The compound belongs to the class of GH secretagogues (growth hormone axis release-stimulating molecules) and is studied in scientific research as a model compound. Tesamorelin is offered exclusively for laboratory and research purposes.

What is Tesamorelin?

Tesamorelin (development code TH9507) is a stabilized GHRH(1-44) analog. While natural GHRH(1-44) is rapidly enzymatically degraded, the trans-3-hexenoyl modification at the N-terminal tyrosine prolongs molecular stability—including against dipeptidylpeptidase-4 (DPP-4). Structurally, it is a long peptide of 44 amino acids with a molecular weight of approximately 5136 Da, making it one of the larger peptide model compounds used in receptor and signaling pathway research.

Within the somatotropic axis, GHRH binds to the GHRH receptor on the anterior lobe of the pituitary. In controlled research systems, Tesamorelin serves as an analog model compound to characterize that receptor interaction and the subsequent signal transduction, entirely independent of any application in humans or animals. Because it retains the intact 1-44 sequence and is not shortened to a fragment, Tesamorelin is regularly used as a reference point for shorter GHRH analogs when researchers wish to isolate the effect of sequence length on receptor binding and enzymatic stability.

Research areas

Research applications for which this connection is used in a laboratory context:

• In vitro research into binding and activation of the GHRH receptor on somatotropic cells
• Modeling of the growth hormone axis and pulsatile release patterns in controlled systems
• Research into the IGF-1 signaling pathway as a downstream readout of GHRH receptor activation
• Studies on the proteolytic stability of N-terminally modified peptides (DPP-4 resistance)
• Comparative receptor study between GHRH analogues and ghrelin receptor agonists
• Models of lipid and glucose metabolism in endocrine research

In these contexts, Tesamorelin is used as a defined reference model compound: the fixed sequence, the known N-terminal modification, and the high purity make it a reproducible tool to map GHRH receptor-mediated signaling pathways and the stability of long peptides.

Tesamorelin compared with related compounds

Tesamorelin belongs to the family of GHRH analogues and is often compared with related secretagogues in research to map differences in sequence length, stability, and signaling pathway:

• Sermorelin Acetate — the shorter GHRH(1-29) fragment against which the complete 1-44 sequence of Tesamorelin is usually compared.
• CJC-1295 without DAC (Mod GRF 1-29) — another stabilized GHRH analog being studied via the same receptor pathway.
• Ipamorelin — a ghrelin receptor agonist (GHRP) that targets a separate signaling pathway and is compared to GHRH analogues in comparative studies.

The pairing of a GHRH analogue with a ghrelin receptor agonist is a classic comparative research model; the pre-mixed version also exists for this purpose. Tesamorelin 11mg + Ipamorelin 6mg-vial.

Specifications

Shape, handling and storage

Tesamorelin is supplied as a freeze-dried powder (lyophilisate). It is available as a single 10 mg vial and as a set of 10 x 10 mg (100 mg total) for investigational setups with a higher throughput. The freeze-dried powder is hygroscopic and photosensitive; store it in a dry, cool, and dark place. Bacteriostatic water is typically used for reconstitution in a laboratory context; store the reconstituted solution refrigerated (2–8 °C) and protected from light. Always follow applicable laboratory guidelines and treat the material as an investigational reagent.

Purity and lab results

Tesamorelin is offered with a controlled purity of ≥ 99% (HPLC). You can find the complete overviews of analysis certificates on our lab results page.

Frequently Asked Questions

What exactly is Tesamorelin?
Tesamorelin is a synthetic GHRH(1-44) analog with a trans-3-hexenoyl group at the N-terminus (development code TH9507). It serves as a peptide model compound in growth hormone axis research.

How does Tesamorelin differ from Sermorelin and CJC-1295?
All three are GHRH analogs. Sermorelin corresponds to the shorter GHRH(1-29) fragment, while Tesamorelin carries the full 1-44 sequence. The N-terminal hexenoyl modification increases stability against enzymatic degradation, similar to the stabilizing modifications in CJC-1295.

How is Tesamorelin handled and stored?
Store as lyophilisate in a cool, dark place; after reconstitution with bacteriostatic water, keep refrigerated (2–8 °C). For use only in a controlled laboratory environment.

Is Tesamorelin suitable for human or animal use?
No. Tesamorelin is supplied exclusively for laboratory and research purposes and is not a medicine.

Where can I find the analysis results?
The purity data and analysis certificates are on the lab results page.

Want to know more? Read our guide: HGH peptides explained: GHRH analogs, GHRPs, and the difference from real growth hormone.

Intended exclusively for laboratory and research purposes. Not for human or animal consumption, or for medical, diagnostic, therapeutic, or cosmetic use. The buyer is 18+ and confirms the research context. Not a medicine.