Lean Performance Bundle

The Lean Performance Bundle is a composite research set of three synthetic peptide and protein analogues, chemically belonging to the insulin-like growth factors, the GHRH analogues, and the synthetic secretagogues. Within scientific research, this combination is studied as a model set for receptor research around the somatotropic axis and as reference material in analytical work. The bundle is offered as six freeze-dried vials, exclusively for laboratory and research purposes.

What is the Lean Performance Bundle?

The set bundles three molecules with different structures. IGF-1 LR3 (Long [Arg³]-IGF-I) is a recombinant protein analog of human IGF-1 with 83 amino acids: arginine replaces glutamic acid at position 3 and the N-terminus carries a thirteen-residue extension. CJC-1295 without DAC, systematically modified GRF(1-29), is a 29-amino acid analog of growth hormone-releasing hormone with substitutions at positions 2, 8, 15, and 27, which stabilize the chain against enzymatic cleavage. Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂.

In research models, the three compounds act at different sites. IGF-1 LR3 is described in vitro as an agonist of the IGF-1 receptor, with a low affinity for binding proteins (IGFBPs), ensuring it remains largely freely available in cell culture. CJC-1295 without DAC binds to the GHRH receptor in cell models; Ipamorelin selectively targets the growth hormone secretagogue receptor (GHS-R1a) in vitro. Three targets within a single signaling pathway make the set useful in comparative structure-activity studies. Consequently, the Lean Performance Bundle is used in scientific research as a model combination and reference substance.

Research areas

In a laboratory context, the Lean Performance Bundle occurs in the following research areas, among others:

• Receptor research into the IGF-1 receptor and intracellular signaling cascades in cell models.
• Research into the GHRH receptor and cAMP-mediated signal transduction in pituitary cell culture systems.
• Model studies of the GHS-R1a receptor and the selectivity of synthetic ligands.
• Biophysical research into ligand-binding protein interactions, including the IGFBP affinity of IGF-1 LR3.
• Analytical method development and validation (HPLC, LC-MS) with the compounds as the reference standard.
• Stability and solubility studies of freeze-dried peptides under controlled conditions.

Each of these applications involves controlled laboratory or preclinical model research.

The Lean Performance Bundle within our research range

Within our product range, this bundle falls under the category of composite research sets: fixed combinations of freeze-dried vials. While this set covers three receptors within a single signaling pathway, other sets in the same product line are built around enzymatic, structural, or other receptor-bound targets. They share the freeze-dried form but differ in molecular class and investigated mechanism.

Specifications

Shape, handling and storage

The bundle is supplied as six sealed glass vials containing freeze-dried powder, two per compound. Unlike solid tablet forms, reconstitution in a suitable solvent is required for lyophilized compounds; until that time, the powder remains sealed. The compounds differ significantly in molecular weight, which is relevant for comparative analyses.

Store the freeze-dried vials in a cool, dark, and dry place in the original packaging; in reconstituted form, keep refrigerated at 2–8 °C. Handle the compounds with the usual laboratory precautions: work in a clean environment, use appropriate protective equipment, and prevent cross-contamination. Keep the packaging out of reach of unauthorized persons.

Composition and lab results

For the freeze-dried compounds in this bundle, a controlled purity of ≥ 99% (HPLC) is maintained, where the stated quantity refers to the net compound per vial.

You can find an overview of the available analytical documentation on our lab results pageThe reports are collected centrally there, so that you can incorporate the data into your own research records.

Frequently Asked Questions

To which class of substances do the compounds in this bundle belong?
Up to three classes: a recombinant protein analog of 83 amino acids, a substituted 29-amino acid analog of growth hormone-releasing hormone, and a synthetic pentapeptide.

Why does IGF-1 LR3 structurally differ from natural IGF-1?
Glutamic acid at position 3 is replaced by arginine, and the N-terminus carries an extension of thirteen residues. In vitro, this strongly reduces the affinity for the IGF-binding proteins, ensuring that the compound remains available as a free ligand in cell culture.

In what form is the bundle delivered?
As six freeze-dried vials: twice IGF-1 LR3, twice CJC-1295 without DAC of 5 mg, and twice Ipamorelin of 5 mg.

How do I store the vials?
Freeze-dried cool, dark and dry in the original packaging; reconstituted refrigerated at 2–8 °C.