Survodutide 10 mg

For laboratory and research purposes only. Not for human or veterinary use.

Survodutide is a synthetic, acylated investigational peptide that is studied in controlled laboratory settings within the framework of peptide-mediated signaling pathways and receptor interaction modeling. In scientific research, the compound is used as a model compound and as a reference standard in analytical work. It is offered as a freeze-dried lyophilisate in a sealed 10 mg investigational vial.

What is Survodutide?

Survodutide is a linear peptide with a molecular mass of approximately 4,232 Da, structured according to the molecular formula C₁₉₂H₂₈₉N₄₇O₆₁The chain is derived from a naturally occurring peptide backbone and features modified amino acid residues at several positions. A C18 fatty acid chain is attached to a lysine residue via a hydrophilic linker. This acylation alters the physicochemical profile—hydrophobicity, aggregation behavior, and protein affinity—making the compound a useful model in research into lipid modification of synthetic peptides.

In research models, Survodutide is described as a dual agonist of two class B G-protein-coupled receptors: the GLP-1 receptor and the glucagon receptor. In in vitro cell models, binding affinity and intracellular signal transduction, including the cAMP response of expressed receptor systems, are examined. Due to its defined molecular profile, the compound regularly serves as reference input in comparative peptide studies. Consequently, Survodutide is used as a model compound and reference substance within scientific research.

Research areas

In a laboratory context, Survodutide occurs in the following research areas, among others:

• Receptor interaction modeling of class B G-protein-coupled receptors and characterizing binding affinity in cell models.
• Studies of peptide-mediated signaling pathways and molecular regulatory networks, including the cAMP response in vitro.
• Structure-activity relationship study into the contribution of amino acid residues to the selectivity of dual receptor ligands.
• Research into lipid modification and the influence of a fatty acid chain on conformation, solubility, and protein affinity.
• Analytical method development and validation (HPLC, LC-MS) using Survodutide as the reference standard.
• Comparative study within the class of acylated synthetic peptides under controlled conditions.

Each of these applications involves controlled laboratory or preclinical model research.

Analytical specification

The material is submitted with a controlled purity of ≥ 99%, determined via high-pressure liquid chromatography (HPLC). Identity and purity are determining parameters in analytical peptide work: in the case of a long, acylated chain, deletion sequences or degradation products can influence the interpretation of measurement results, especially when affinity values ​​are derived from a concentration series. An overview of the available analysis documentation can be found on our lab results page.

Specifications

Shape, handling and storage

Survodutide is supplied as freeze-dried lyophilisate in a sealed 10 mg vial. The lyophilization process preserves the molecular integrity of the peptide chain during storage and transport. The material has a white to off-white appearance and presents as a loose powder or as a compressed cake; both are normal and relate to the conditions during freeze-drying. The lyophilisate is hygroscopic.

Store the unopened lyophilized substance in a cool, dry, and dark place in the original packaging, protected from light and moisture. Allow a cooled vial to reach room temperature before opening to prevent condensation from forming on the glass. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, prevent cross-contamination, and keep the packaging out of reach of unauthorized persons. Dispose of residual material in accordance with applicable laboratory guidelines.

Survodutide within our research range

Within our product range, Survodutide falls under the category of freeze-dried investigational compounds in vial form. Researchers working with this category frequently combine the compound with other peptides that are studied via their own molecular target. While Survodutide distinguishes itself through an acylated chain with affinity for two receptors, other components within the same product line have been specifically chosen to cover enzymatic or metal-bound targets. These compounds share the vial form but differ in molecular class and investigated mechanism.

Frequently Asked Questions

To which class of substances does Survodutide belong?
Survodutide is a synthetic, acylated peptide described in the literature as a dual agonist of two class B G-protein-coupled receptors. It is known under the development code BI 456906.

Why is molecular structure relevant in research?
The defined peptide chain with an attached C18 fatty acid chain gives the molecule a well-characterizable profile. This makes the compound useful as a model in receptor interaction research and as a reference in analytical methods.

In what form is the compound supplied?
As freeze-dried lyophilisate in a sealed 10 mg vial, with a purity of ≥ 99% (HPLC).

What does the material look like?
White to off-white lyophilized material, as a loose powder or compressed cake. The material is hygroscopic and must be briefly exposed to ambient air.

How do I store the material?
Store in a cool, dry, and dark place in the original packaging, protected from light and moisture.