Clomifen 50 mg

Clomiphene is a synthetic small molecule from the group of triphenylethylene derivatives, chemically a substituted chloroethene with a basic ether side chain. In scientific research, it is studied as a model compound for nuclear receptor biochemistry and as a reference standard in analytical work. This compound is offered as 50 mg tablets, exclusively for laboratory and research purposes.

What is Clomiphene?

Clomiphene (2-[4-(2-chloro-1,2-diphenylethene-1-yl)phenoxy]-N,N-diethylethaneamine) is structured around a triple-substituted carbon-carbon double bond: two phenyl rings, a chlorine atom, and a phenoxy ring with a diethylaminoethyl tail. Because rotation around this double bond is not possible, the substance exists as two stable geometric isomers, the (Z)-form zuclomifene and the (E)-form enclomiphene. The combination of a rigid triphenylethylene skeleton with a flexible, protonable side chain makes the compound a widely used model in structure-activity research and in the separation analysis of geometric isomers.

In research models, Clomiphene acts as a selective modulator of the estrogen receptor. In vitro, it binds to the ligand binding cavity of receptor subtypes ERα and ERβ, where the side chain prevents helix 12 from assuming the closed conformation. In cell models, this results in a cell type-dependent pattern of coactivator and copressor recruitment, with both isomers differing in affinity and residence time at the receptor. Consequently, Clomiphene is used as a model compound and reference substance in scientific research.

Forschungsgebiete

In a laboratory context, Clomiphene occurs in the following research areas, among others:

• Receptor binding studies on affinity and binding kinetics of the estrogen receptor subtypes ERα and ERβ in vitro.
• Structure-activity study within the triphenylethylene series, comparing the effect of halogenation and side chain length on the binding cavity.
• Isomeric study into the separate contribution of the (Z) and (E) forms to the observed binding profile.
• Cell culture models in which coregulator recruitment and receptor-dependent gene expression are monitored.
• Analytical method development and validation (HPLC, LC-MS) using Clomiphene as the reference standard for isomer separation.
• Stability and solubility studies of lipophilic, basic small molecules under controlled conditions.

Jede dieser Anwendungen beinhaltet kontrollierte Labor- oder präklinische Modellforschung.

Clomiphene in our research assortment

Clomiphene falls under the category of oral investigational compounds in solid tablet form within our range. Researchers working with this category regularly place the compound alongside other small molecules that are studied via their own biochemical target. While Clomiphene focuses on modulation of a nuclear receptor, other components within the same product line have been specifically chosen to cover enzyme-linked targets or other receptor families. These compounds share the solid tablet form and the standardized amount of active substance per unit, but differ fundamentally in molecular class and the mechanism under investigation.

Spezifikationen

Form, Handhabung und Lagerung

Clomiphene is supplied as solid tablets with a standardized amount of 50 mg per tablet, packaged in units of 100. The solid form can be weighed directly in a laboratory setup; for chromatographic or spectroscopic work, the material is usually dissolved in a suitable analytical medium, whereby the basic side chain makes the solubility pH-dependent.

Store the tablets dry at room temperature, protected from direct light and moisture, in the original packaging. Triphenylethylenes are sensitive to prolonged exposure to light, which can promote isomerization; storage in the dark keeps the isomer ratio stable. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Zusammensetzung und Laborergebnisse

For this compound, the content is expressed as the amount of active substance per tablet (50 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations. The relevant specification is therefore the uniform distribution of the active substance across the units.

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Häufig gestellte Fragen

To which substance class does Clomiphene belong?
Clomiphene is a synthetic small molecule from the triphenylethylene series and is classified as a selective estrogen receptor modulator. It is not a peptide and therefore contains no amino acid sequence.

Why are the two isomers relevant in research?
Because rotation around the central double bond is not possible, a (Z)- and an (E)-form exist side by side. Both occupy a different position in the bond cavity and exhibit their own affinity in vitro, making the mixture a useful model for stereoselective separation.

In welcher Form wird die Verbindung geliefert?
As solid tablets with 50 mg of active substance per tablet, packed in units of 100.

How do I store the tablets?
Dry, at room temperature and protected from light and moisture, preferably in the original packaging.