SNAP-8 10 mg

SNAP-8 (Acetyl Glutamyl Octapeptide-3) er et syntetisk, acetyleret oktapeptid, hvis sekvens er afledt af den N-terminale region af SNAP-25-proteinet, en kernekomponent i SNARE-komplekset. Det tilhører familien af ​​acetylerede peptider, der undersøges som modelforbindelser i peptid- og kosmetisk kemi. Inden for videnskabelig forskning studeres SNAP-8 i relation til vesikulær signalering og stabiliteten af ​​korte syntetiske peptider. Udelukkende beregnet til laboratorie- og forskningsformål.

Hvad er SNAP-8?

SNAP-8 er et oktapeptid med aminosyresekvensen Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (forkortet Ac-EEMQRRAD-NH₂). Forbindelsen er en udvidet analog af Argirelin (Acetyl Hexapeptide-8, også kaldet Acetyl Hexapeptide-3): hvor dette molekyle har seks aminosyrer, tilføjer SNAP-8 to ekstra rester (alanin og asparaginsyre) til C-terminalen. N-terminalen bærer en acetylgruppe, og C-terminalen en amidgruppe. Begge modifikationer øger modstanden mod nedbrydning af amino- og carboxypeptidaser, hvilket gør SNAP-8 til en strukturelt stabil model til forskning i korte peptider.

Forskningsmæssig betydning af SNAP-8 stammer fra denne afledte sekvens. Fordi fragmentet efterligner det N-terminale motiv af SNAP-25, bruges det i laboratoriesammenhæng som en modelforbindelse til at studere sammensætningen af ​​SNARE-komplekset - proteinkomplekset, der driver vesikelfusion - og den tilhørende frigivelse af signalmolekyler. I denne forstand fungerer SNAP-8 som et defineret, reproducerbart værktøj til mekanistisk forskning, ikke som en forbindelse med en anvendelse uden for laboratoriet.

Forskningsområder

I laboratoriesammenhæng anvendes SNAP-8 blandt andet inden for følgende forskningsområder:

• SNARE-kompleks og SNAP-25-forskning — modellink til samling af SNARE-fusionskomplekset i in vitro-vesikelfusionsmodeller.
• Vesikulær signalering — modeller vedrørende frigivelse af katekolaminer og acetylkolin ved den neuromuskulære forbindelse i kontrollerede systemer.
• Dermatologiske peptidmodeller — forskning i mimik muskelcellesignalering og ekstracellulær matrix-relaterede komponenter i cellekultur.
• Peptidformulering og stabilitet — undersøgelse af opløselighed og proteolytisk stabilitet af acetylerede og amiderede oktapeptider.
• Struktur-aktivitetsundersøgelse (SAR) — comparison with shorter argireline-like analogues to model the effect of sequence length.
• Analytical reference — use as an HPLC reference standard in the characterization of synthetic peptides.

SNAP-8 compared with related compounds

Within the range of investigational peptides with a dermatological research background, SNAP-8 stands alongside several related molecules that each model a different mechanism. GHK-Cu is a copper tripeptide that is classically studied in models involving the extracellular matrix and collagen expression, while Matrixyl as a palmitoyl pentapeptide features in collagen and skin research models. Whereas those two focus on matrix and synthesis pathways, SNAP-8 falls within the SNARE and signaling molecule domain, making the molecules complementary in comparative research.

SNAP-8 also appears as a component in a topical research formulation: the GHK-Cu and SNAP-8 Serum 30ml combines both peptides for research into concurrent matrix and signaling molecule models. The separate SNAP-8 vial offered here is intended for researchers who wish to reconstitute and characterize the compound separately.

Specifikationer

Form, håndtering og opbevaring

SNAP-8 is supplied as a freeze-dried powder (lyophilisate) of 10 mg per vial. In a research context, the lyophilisate is reconstituted with a suitable solvent such as bacteriostatic or sterile water before use; the octapeptide is highly water-soluble. Handle the powder in a cool place and protected from light and moisture, and avoid repeated freeze-thaw cycles to maintain structural integrity.

The dry lyophilisate is most stable when stored in a cool, dark place. After reconstitution, the solution is usually stored refrigerated (2–8 °C) and used within a limited period. Work with clean, calibrated materials and record the concentration and date of reconstitution so that measurements remain reproducible. In research, dosages are expressed in mg of active substance per experiment.

Renhed og laboratorieresultater

SNAP-8 is offered with a controlled purity of ≥ 99%, determined via HPLC. This degree of purity makes the compound suitable as a defined model compound and reference standard in analytical and preclinical research. Certificates of analysis and lab results of our research compounds can be found bundled on the side med laboratorieresultater.

Ofte stillede spørgsmål

What exactly is SNAP-8?
SNAP-8 is a synthetic, acetylated octapeptide (Acetyl Glutamyl Octapeptide-3) with a sequence derived from the SNAP-25 protein. It is used in scientific research as a model compound regarding vesicular signaling and peptide stability.

How does SNAP-8 differ from Argireline?
SNAP-8 is an extended analog of Argireline (Acetyl Hexapeptide-8). Whereas Argireline has six amino acids, SNAP-8 carries two extra residues (Ala-Asp) at the C-terminal end, making it a longer model variant for comparative research.

In what form is SNAP-8 delivered?
As a freeze-dried powder (lyophilisate) of 10 mg per vial, with a purity of ≥ 99% (HPLC). In research, it is reconstituted with bacteriostatic or sterile water.

How do I store SNAP-8?
Store the dry lyophilisate in a cool, dark place, protected from light and moisture. After reconstitution, the solution is stored refrigerated (2–8 °C).

Is SNAP-8 suitable for human or cosmetic use?
No. SNAP-8 is offered exclusively for laboratory and research purposes and is not intended for human or animal consumption or for cosmetic use.

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