SLU-PP-332 + BAM15 (oral)

SLU-PP-332 + BAM15 (oral) is a research compound belonging to the class of small organic molecules, chemically a two-component mixture of an acylhydrazone and a fluorinated oxadiazolopyrazine. In scientific research, it is studied as a model mixture for nuclear receptor and bioenergetics research and as a multicomponent reference mixture in analytical work. This combination is offered as capsules, exclusively for laboratory and research purposes.

What is SLU-PP-332 + BAM15 (oral)?

The two components belong to completely different chemical families. SLU-PP-332 (4-hydroxy-N'-[(naphthalene-2-yl)methylidene]benzohydrazide) is an acylhydrazone: a phenolic hydrazide connected to a naphthalene ring via a carbon-nitrogen double bond. This hydrazone bond is the chemically interesting element, because E and Z isomers exist around the C=N axis and the bond is hydrolysis-sensitive under acidic conditions; moreover, the conjugated naphthalene system provides strong UV absorption. BAM15 (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine), on the other hand, is a compact, electron-deficient system in which an oxadiazole ring is fused with a pyrazine core, with a 2-fluorophenyl group on either side. That electron-poor core sharply lowers the pKa of the adjacent amino groups, allowing the molecule in its deprotonated form to spread a charge over a large nonpolar surface.

In research models, both substances are used for distinct reasons. SLU-PP-332 is studied in vitro as an agonist of estrogen-related receptors (ERRα, ERRβ, and ERRγ), nuclear receptors that act as transcription factors; in cell models, activation is monitored using reporter gene assays. BAM15 serves as a protonophore in isolated mitochondria: by transporting protons across the inner membrane, it decouples the electron transport chain from ATP synthesis, which becomes visible through oxygen consumption measurements. Consequently, this combination is used in scientific research as a model mixture and reference substance.

Forskningsområder

In a laboratory context, SLU-PP-332 + BAM15 (oral) occurs in the following research directions, among others:

• Nuclear receptor research into the ERR family, with reporter gene and co-activator recruitment assays in vitro.
• Bioenergetic research into oxidative phosphorylation and membrane potential in isolated mitochondria.
• Biophysical studies into the relationship between pKa, lipophilicity, and proton transport across a lipid bilayer.
• Structure-activity relationship study on acylhydrazones with varied aromatic substituents.
• Analytical method development and validation (HPLC with UV detection, LC-MS), in which this mixture tests the separating capacity.
• Stability and solubility studies of hydrazones and fluorinated heterocycles.

Hver af disse anvendelser involverer kontrolleret laboratorie- eller præklinisk modelforskning.

SLU-PP-332 + BAM15 (oral) in our research range

Within our range, this combination falls under the category of oral investigation compounds in solid capsule form. Researchers working with this category typically select multiple compounds, each with its own biochemical target. While this mixture targets a nuclear receptor and the mitochondrial inner membrane, other components within the same product line have been chosen to cover enzyme-linked or peptide-mediated targets. These compounds share the capsule form but differ in molecular class and investigated mechanism.

Specifikationer

Form, håndtering og opbevaring

This compound is supplied as capsules containing 250 mcg SLU-PP-332 and 50 mcg BAM15 per capsule, packed in quantities of 60. The contents can be weighed in a laboratory setup or prepared for further analysis according to one's own extraction protocol. Both components are poorly water-soluble and highly UV-absorbent, making protection against light and a deliberate choice of the detection wavelength relevant considerations.

Store the capsules dry at room temperature, protected from direct light and moisture, in the original packaging. Observe the connection with the usual laboratory precautions: clean environment, suitable personal protective equipment, no cross-contamination with other research material. Keep the packaging out of reach of unauthorized persons.

Sammensætning og laboratorieresultater

For this compound, the content is expressed as the amount of active substance per capsule, namely 250 mcg SLU-PP-332 and 50 mcg BAM15, rather than as a purity percentage. This is common practice for capsule formulations with a carrier matrix.

Du kan finde en oversigt over den tilgængelige analytiske dokumentation på vores side med laboratorieresultaterThe reports are collected centrally there.

Ofte stillede spørgsmål

To which classes of substances do the two components belong?
Both are small organic molecules, not peptides: an acylhydrazone with a naphthalene and phenol group, and a fluorinated oxadiazolopyrazine.

What makes the hydrazone bond in SLU-PP-332 chemically relevant?
E and Z isomers exist around the C=N bond, and the bond is susceptible to hydrolysis under acidic conditions: a directly measurable point of attention in stability studies.

In what form is the combination delivered?
As capsules containing 250 mcg SLU-PP-332 and 50 mcg BAM15 per capsule, packed in units of 60.

How do I store the capsules?
Dry, at room temperature and protected from light and moisture, in the original packaging.