Pinealon hætteglas 20 mg

Pinealon er et syntetisk kort peptid fra gruppen af Khavinson-bioregulatorer, kemisk et tripeptid opbygget af glutaminsyre, asparaginsyre og arginin. Inden for videnskabelig forskning undersøges det som modelforbindelse for peptid-nukleinsyre-interaktion og som referencestandard i analytisk arbejde. Denne forbindelse tilbydes som frysetørret pulver med 20 mg pr. hætteglas, udelukkende til laboratorie- og forskningsformål.

What is Pinealon?

Pinealon (L-alpha-glutamyl-L-alpha-aspartyl-L-arginine, sekvens Glu-Asp-Arg, i litteraturen kode EDR) er et lineært tripeptid med molekylformlen C₁₅H₂₆N₆O₈ og en molekylvægt på 418,40 Da. Kæden kombinerer to sure sidekæder — glutaminsyre og asparaginsyre — med det stærkt basiske arginin, så molekylet har både negativ og positiv ladningstæthed over en meget kort afstand. Denne ladningsfordeling i blot tre aminosyrer gør forbindelsen til en ofte anvendt model for interaktionen mellem korte peptider og ladede biopolymerer.

I forskningsmodeller undersøges Pinealon som ligand for dobbeltstrenget DNA: spektroskopi og molekylær modellering beskriver, hvordan korte peptider med denne aminosyrekonfiguration in vitro retter sig mod bestemte nukleotidsekvenser i dobbeltspiralens store fure. I cellemodeller undersøges det dernæst, om en sådan binding hænger sammen med ændringer i kromatinets pakning — overgangen fra tætpakket heterokromatin til mere tilgængeligt eukromatin — og dermed med transkriptionen af bestemte gener. Denne arbejdshypotese fra Khavinsons forskningslinje er hidtil især undersøgt in vitro og i prækliniske modeller. Inden for videnskabelig forskning anvendes Pinealon derfor som modelforbindelse og referencestof.

Forskningsområder

I en laboratoriekontekst optræder Pinealon blandt andet inden for følgende forskningsområder:

• Biophysical research into the binding of short peptides to double-stranded DNA, measured using spectroscopic techniques in vitro.
• Molecular modeling studies of the structure-activity relationship of tripeptides with an acid-base charge profile.
• Epigenetically oriented modeling of chromatin packing and the accessibility of promoter regions.
• Gene expression research in cell culture systems, in which transcript levels are monitored in vitro.
• Analytical method development and validation (HPLC, LC-MS) using Pinealon as the reference standard.
• Stability and solubility studies of freeze-dried tripeptides under controlled conditions.

Hver af disse anvendelser involverer kontrolleret laboratorie- eller præklinisk modelforskning.

Pinealon in our research assortment

Pinealon falls under the category of freeze-dried peptides in vial form within our range. Researchers in this category regularly combine the compound with other short peptides that are studied via their own biochemical target. While Pinealon focuses on the interaction between a short peptide and nucleic acids, other components in the same product line have been chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried form but differ fundamentally in chain length and investigated mechanism.

Specifikationer

Form, håndtering og opbevaring

Pinealon is supplied as a freeze-dried powder, standardized to 20 mg per vial. Unlike a solid tablet form, a lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work; the dry state serves the stability of the peptide chain during transport and storage.

Store the unopened vial refrigerated, protected from direct light and moisture, in the original packaging; for longer periods, the dry lyophilisate should be stored frozen. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Sammensætning og laboratorieresultater

This lyophilisate has a controlled purity of ≥ 99% (HPLC), determined on the peptide chain Glu-Asp-Arg. The vial contains exclusively the freeze-dried peptide.

Du kan finde en oversigt over den tilgængelige analytiske dokumentation på vores side med laboratorieresultaterRapporterne samles centralt der, så du kan integrere dataene i dine egne forskningsregistre.

Ofte stillede spørgsmål

To which class of substances does Pinealon belong?
Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg and belongs to the short peptide bioregulators (cytogens) of the Khavinson research line. It is therefore not a small organic molecule, but an amino acid chain.

What is being investigated regarding the DNA interaction of Pinealon?
In vitro studies using spectroscopy and molecular modeling describe how the EDR motif targets specific nucleotide sequences in the major groove of the double helix. In cell models, the question then is whether this binding is associated with looser chromatin packing and altered transcription — the central focus of mechanistic laboratory research into this connection.

I hvilken form leveres forbindelsen?
As a freeze-dried powder of 20 mg per vial. A lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work.

Hvordan opbevarer jeg flasken?
Refrigerated, protected from light and moisture, preferably in the original packaging.