MGF 2mg

MGF (Mechano Growth Factor) er en splejsningsvariant af insulinlignende vækstfaktor 1 (IGF-1), specifikt det C-terminale E-domænepeptid, der opstår ved alternativ splejsning af IGF-1-genet. Det er et syntetisk peptid af 24 aminosyrer, også omtalt i litteraturen som IGF-1Ec. Inden for videnskabelig forskning studeres det som en modelforbindelse vedrørende IGF-1-aksen, mekanotransduktion og cellulære reparationsveje. Udelukkende beregnet til laboratorie- og forskningsformål.

Hvad er MGF?

MGF står for Mechano Growth Factor og omtales også i den videnskabelige litteratur som IGF-1Ec — "Ec"-splejsningsvarianten af ​​insulinlignende vækstfaktor 1 (et vækstfaktorprotein fra insulinfamilien). Når IGF-1-genet alternativt splejses under mekaniske eller hypoxiske (iltfattige) forhold, dannes et precursorprotein, hvis C-terminale E-domæne frigives efter enzymatisk spaltning som det 24 aminosyrer store MGF E-peptid; den resterende del danner modent IGF-1. Denne strukturelle lighed placerer MGF inden for den bredere IGF-1-signalfamilie, men med sin egen, kortlivede E-domæneprofil, der adskiller den fra det komplette IGF-1-molekyle.

Som en forbindelse af forskningskvalitet tilbydes MGF som et frysetørret pulver (lyofilisat) med en defineret aminosyresekvens. I kontrollerede systemer fungerer det som et strukturelt nøjagtigt værktøj til at modellere dynamikken i IGF-1-aksen, satellitcellebiologi og mekanisk rettet signalering. Inden for videnskabelig forskning studeres det udelukkende som en modelforbindelse uden nogen anvendelse i mennesker eller dyr.

Forskningsområder

I laboratoriesammenhæng anvendes MGF blandt andet i følgende forskningsområder:

• Forskning i IGF-1-aksen og rollen af ​​E-domæne-splejsningsvarianter i cellulære signalveje in vitro.
• Modellering af satellitcelleaktivering og myoblastproliferation i cellekultursystemer.
• Studier af mekanotransduktion — den proces, hvorved celler omsætter mekanisk belastning til biokemiske signaler.
• Modeller for vævsreparation og regenerering efter kontrolleret mekanisk eller hypoksisk stress.
• Forskning i konformationsstabilitet og proteolytisk nedbrydning af korte E-domænepeptider.
• Brug som reference- og sammenligningsstandard sammen med andre komponenter i væksthormon-IGF-1-aksen.

These applications concern exclusively preclinical, in vitro, or analytical research models and do not describe effects in humans or animals.

MGF compared with related compounds

MGF is often studied in research alongside other molecules from the growth hormone-IGF-1 axis. The PEG MGFThe -variant is a PEGylated form of the same E-domain peptide, in which the polyethylene glycol group in the study serves to compare the conformational stability and degradation rate with the unmodified peptide. IGF-1 LR3 is a structurally modified IGF-1 analog that is used as the longer reference standard for the IGF-1 axis. Further upstream on the same signal path lie the secretagogues and GHRH analogs: Tesamorelin (a synthetic GHRH(1-44) analog) and Ipamorelin (a selective agonist of the ghrelin receptor) are being studied as upstream modulators of growth hormone signaling. Together, these compounds form a spectrum that allows researchers to model different levels of the same axis.

Specifikationer

Form, håndtering og opbevaring

MGF is supplied as freeze-dried powder (lyophilized powder) in a 2 mg vial. The lyophilized powder is most stable in its dry form and should be stored refrigerated and protected from light and moisture; for long-term storage, a temperature of −20 °C is maintained. Reconstitution in a laboratory context is typically performed using bacteriostatic water. After reconstitution, the solution is stored refrigerated (2–8 °C) and protected from repeated temperature fluctuations, as short peptides are susceptible to proteolytic degradation. Handle the sample with standard laboratory hygiene and limit unnecessary freeze-thaw cycles to preserve sequence integrity.

Renhed og laboratorieresultater

MGF is offered with a controlled purity of ≥ 99%, determined by high-performance liquid chromatography (HPLC) — a standard technique for establishing the identity and homogeneity of synthetic peptides. Certificates of analysis and additional lab results can be found on our website. side med laboratorieresultater.

Ofte stillede spørgsmål

What is the difference between MGF and IGF-1?
MGF is the C-terminal E-domain peptide formed by alternative splicing of the IGF-1 gene; mature IGF-1 is the remaining part left after enzymatic cleavage. Both share the same genetic origin, but MGF has its own, shorter structural profile.

What is the difference between MGF and PEG MGF?
PEG MGF is the same E-domain sequence featuring a polyethylene glycol group. In research, PEGylation is used to compare the conformational stability and degradation rate with the unmodified peptide.

In what form is MGF supplied?
As freeze-dried powder (lyophilized powder) in a 2 mg vial, with a purity of ≥ 99% (HPLC).

How is MGF stored?
Dry, refrigerated, and protected from light and moisture; for long-term storage at −20 °C. After reconstitution, store refrigerated (2–8 °C) and avoid freeze-thaw cycles as much as possible.

Is MGF suitable for use in humans or animals?
No. MGF is offered exclusively for laboratory and research purposes and is not a medicine, dietary supplement, or cosmetic product.

Vil du vide mere? Læs vores guide: Forklaring af HGH-peptider: GHRH-analoger, GHRP'er og forskellen fra ægte væksthormon.

Udelukkende beregnet til laboratorie- og forskningsformål. Ikke til konsum af mennesker eller dyr, eller til medicinsk, diagnostisk, terapeutisk eller kosmetisk brug. Køber er over 18 år og bekræfter forskningskonteksten. Ikke et lægemiddel.