Glutation (GSH) \u00e4r en naturligt f\u00f6rekommande tripeptid, kemiskt sett en tiolinneh\u00e5llande \u03b3-glutamylpeptid. Inom vetenskaplig forskning studeras den som en modellf\u00f6rening f\u00f6r redoxbiokemi och enzymologi och som en referensstandard i analysarbete. Denna f\u00f6rening erbjuds som ett frystorkat pulver p\u00e5 1500 mg per injektionsflaska, exklusivt f\u00f6r laboratorie- och forsknings\u00e4ndam\u00e5l.<\/p>\n
Glutation (\u03b3-L-glutamyl-L-cysteinyl-glycin) \u00e4r en tripeptid som best\u00e5r av aminosyrorna glutaminsyra, cystein och glycin, med sekvensen \u03b3-Glu-Cys-Gly. Den k\u00e4nnetecknas av en ovanlig \u03b3-peptidbindning: glutamatresten \u00e4r kopplad till cystein via sin sidokedja snarare \u00e4n \u03b1-karboxylgruppen, vilket g\u00f6r molekylen resistent mot de flesta vanliga aminopeptidaser. Den fria tiolgruppen i cysteinresten bildar den reaktiva k\u00e4rnan. Det \u00e4r just denna kombination av en atypisk peptidbindning och en fri sulfhydryl som g\u00f6r glutation till en allm\u00e4nt anv\u00e4nd modellmolekyl inom peptidkemi och tiolbiokemi.<\/p>\n
I forskningsmodeller spelar f\u00f6reningen en central roll i redoxparet GSH\/GSSG: in vitro kan tv\u00e5 GSH-molekyler bilda en disulfidbrygga till den oxiderade dimeren GSSG, som sedan omvandlas tillbaka till den reducerade formen av NADPH-beroende glutationreduktas. Dessutom fungerar glutation i cellmodeller som en kofaktor f\u00f6r glutationperoxidaser och som ett substrat f\u00f6r glutation S-transferaser, vilka kopplar tiolgruppen till opol\u00e4ra elektrofiler. Biosyntesen sker i tv\u00e5 ATP-beroende steg via glutamatcysteinligas och glutationsyntetas, som tillsammans bildar k\u00e4rnan i \u03b3-glutamylcykeln. F\u00f6ljaktligen anv\u00e4nds glutation som modellf\u00f6rening och referenssubstans i vetenskaplig forskning.<\/p>\n
I laboratoriesammanhang f\u00f6rekommer glutation bland annat inom f\u00f6ljande forskningsomr\u00e5den:<\/p>\n
Var och en av dessa till\u00e4mpningar involverar kontrollerad laboratorie- eller preklinisk modellforskning.<\/p>\n
Glutathione falls under the category of freeze-dried research peptides in vial form within our range. Researchers working with this category frequently combine the compound with other peptides studied via their own biochemical targets. While Glutathione focuses on thiol chemistry and redox-dependent enzyme systems, other components within the same product line have been specifically chosen to cover receptor-linked or signal-mediated targets. These compounds share the freeze-dried vial form but differ fundamentally in amino acid composition and investigated mechanism.<\/p>\n
| Specifikation<\/th>\n | V\u00e4rde<\/th>\n<\/tr>\n<\/thead>\n | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Prov<\/td>\n | Glutathione (GSH)<\/td>\n<\/tr>\n | ||||||||||
| Synonymer<\/td>\n | \u03b3-L-glutamyl-L-cysteinyl-glycine; L-glutathione (reduced); \u03b3-Glu-Cys-Gly<\/td>\n<\/tr>\n | ||||||||||
| CAS-nummer<\/td>\n | 70-18-8<\/td>\n<\/tr>\n | ||||||||||
| Molekylformel \/ vikt<\/td>\n | C10<\/sub>H17<\/sub>N3<\/sub>O6<\/sub>S \/ 307.33 Da<\/td>\n<\/tr>\n| PubChem CID<\/td>\n | 124886<\/td>\n<\/tr>\n | Klass<\/td>\n | Tripeptide, thiol-containing \u03b3-glutamyl peptide<\/td>\n<\/tr>\n | Form<\/td>\n | Lyofilisat (frystorkat pulver)<\/td>\n<\/tr>\n | M\u00e4ngd per flaska<\/td>\n | 1500 mg<\/td>\n<\/tr>\n | Lagring<\/td>\n | F\u00f6rvaras kylt, skyddat fr\u00e5n ljus och fukt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n | Form, hantering och f\u00f6rvaring<\/h2>\nGlutathione is supplied as a freeze-dried powder in a sealed glass vial containing a standardized quantity of 1500 mg. Unlike a solid tablet form, this lyophilisate is intended to be dissolved in a suitable solvent in a laboratory setup before analytical work takes place. The free thiol group is susceptible to oxidation to GSSG in solution; therefore, the compound is offered in freeze-dried form.<\/p>\n Store the vial refrigerated, protected from direct light and moisture, in the original packaging and with the seal intact. Handle the connection with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Avoid repeated temperature changes and keep the packaging out of reach of unauthorized persons.<\/p>\n Sammans\u00e4ttning och labresultat<\/h2>\nThe lyophilisate contains glutathione with a controlled purity of \u2265 99% (HPLC). The vial contains exclusively the freeze-dried compound, without added excipients or preservatives.<\/p>\n |