MGF (Mechano Growth Factor) is a splice variant of insulin-like growth factor 1 (IGF-1), specifically the C-terminal E-domain peptide that arises from alternative splicing of the IGF-1 gene. It is a synthetic peptide of 24 amino acids, also referred to in the literature as IGF-1Ec. Within scientific research, it is studied as a model compound regarding the IGF-1 axis, mechanotransduction, and cellular repair pathways. Intended exclusively for laboratory and research purposes.<\/p>\n
MGF stands for Mechano Growth Factor and is also referred to in the scientific literature as IGF-1Ec \u2014 the \u201cEc\u201d splice variant of insulin-like growth factor 1 (a growth factor protein from the insulin family). When the IGF-1 gene is alternatively spliced \u200b\u200bunder mechanical or hypoxic (oxygen-poor) conditions, a precursor protein is formed whose C-terminal E-domain is released after enzymatic cleavage as the 24-amino acid MGF E-peptide; the remaining part forms mature IGF-1. This structural similarity places MGF within the broader IGF-1 signaling family, but with its own, short-lived E-domain profile that distinguishes it from the complete IGF-1 molecule.<\/p>\n
As a research-grade compound, MGF is offered as a freeze-dried powder (lyophilisate) with a defined amino acid sequence. In controlled systems, it serves as a structurally accurate tool to model the dynamics of the IGF-1 axis, satellite cell biology, and mechanically directed signaling. Within scientific research, it is studied exclusively as a model compound, without any application in humans or animals.<\/p>\n
In a laboratory context, MGF is used in the following research lines, among others:<\/p>\n
These applications concern exclusively preclinical, in vitro, or analytical research models and do not describe effects in humans or animals.<\/p>\n
MGF is often studied in research alongside other molecules from the growth hormone-IGF-1 axis. The PEG-MGF<\/a>The -variant is a PEGylated form of the same E-domain peptide, in which the polyethylene glycol group in the study serves to compare the conformational stability and degradation rate with the unmodified peptide. IGF-1 LR3<\/a> is a structurally modified IGF-1 analog that is used as the longer reference standard for the IGF-1 axis. Further upstream on the same signal path lie the secretagogues and GHRH analogs: Tesamorelin<\/a> (a synthetic GHRH(1-44) analog) and Ipamorelin<\/a> (a selective agonist of the ghrelin receptor) are being studied as upstream modulators of growth hormone signaling. Together, these compounds form a spectrum that allows researchers to model different levels of the same axis.<\/p>\nSpecifikationer<\/h2>\n
| Specifikation<\/th>\n | V\u00e4rde<\/th>\n<\/tr>\n<\/thead>\n |
|---|---|
| Prov<\/td>\n | MGF (Mechano Growth Factor)<\/td>\n<\/tr>\n |
| Synonymer<\/td>\n | IGF-1Ec, MGF E-peptide (IGF-1 splice variant)<\/td>\n<\/tr>\n |
| Sekvens<\/td>\n | YQPPSTNKNTKSQRRKGSTFEERK (24 amino acids)<\/td>\n<\/tr>\n |
| Molekylformel \/ vikt<\/td>\n | C\u2081\u2082\u2081H\u2081\u2089\u2089N\u2084\u2081O\u2084\u2080 \/ 2868.1 Da<\/td>\n<\/tr>\n |
| PubChem CID<\/td>\n | 175675731<\/td>\n<\/tr>\n |
| Klass<\/td>\n | IGF-1 splice variant (E domain peptide)<\/td>\n<\/tr>\n |
| Form<\/td>\n | Lyophilized powder (dry powder) \u2014 2 mg per vial<\/td>\n<\/tr>\n |
| Renhet<\/td>\n | \u2265 99 % (HPLC)<\/td>\n<\/tr>\n |
| Lagring<\/td>\n | Store refrigerated or at \u221220 \u00b0C, protected from light and moisture.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nForm, hantering och f\u00f6rvaring<\/h2>\nMGF is supplied as freeze-dried powder (lyophilized powder) in a 2 mg vial. The lyophilized powder is most stable in its dry form and should be stored refrigerated and protected from light and moisture; for long-term storage, a temperature of \u221220 \u00b0C is maintained. Reconstitution in a laboratory context is typically performed using bacteriostatic water. After reconstitution, the solution is stored refrigerated (2\u20138 \u00b0C) and protected from repeated temperature fluctuations, as short peptides are susceptible to proteolytic degradation. Handle the sample with standard laboratory hygiene and limit unnecessary freeze-thaw cycles to preserve sequence integrity.<\/p>\n Renhets- och laboratorieresultat<\/h2>\nMGF is offered with a controlled purity of \u2265 99%, determined by high-performance liquid chromatography (HPLC) \u2014 a standard technique for establishing the identity and homogeneity of synthetic peptides. Certificates of analysis and additional lab results can be found on our website. sida med labresultat<\/a>.<\/p>\n What is the difference between MGF and IGF-1?<\/strong> What is the difference between MGF and PEG MGF?<\/strong> In what form is MGF supplied?<\/strong> How is MGF stored?<\/strong> |