{"id":2564,"date":"2026-09-01T09:10:29","date_gmt":"2026-09-01T09:10:29","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2564"},"modified":"2026-09-02T12:17:04","modified_gmt":"2026-09-02T12:17:04","slug":"hgh-fragment-176-191-5mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sl\/product\/hgh-fragment-176-191-5mg\/","title":{"rendered":"Fragment rastnega hormona 176-191 5 mg"},"content":{"rendered":"<p>Fragment HGH 176-191 je sinteti\u010dni peptidni fragment, kemi\u010dno veriga \u0161estnajstih aminokislin, ki ustrezajo C-terminalnemu delu somatotropina. V znanstvenih raziskavah se preu\u010duje kot modelna spojina za raziskave receptorjev in prenosa signalov ter kot referen\u010dni standard pri analiti\u010dnem delu. Ta spojina je na voljo kot liofiliziran pra\u0161ek s 5 mg na vialo, izklju\u010dno za laboratorijske in raziskovalne namene.<\/p>\n<h2>Kaj je fragment HGH 176-191?<\/h2>\n<p>Fragment HGH 176-191, sistemati\u010dno opisan kot somatotropin (176-191), ima zaporedje Phe-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe. Dva cisteinska ostanka na polo\u017eajih 7 in 14 tvorita intramolekularni disulfidni most, zaradi \u010desar fragment prevzame zaprto zanko, ki pribli\u017eno ustreza prostorski orientaciji C-terminalnega dela mati\u010dne molekule. Zaradi te kombinacije kratke verige in fiksne konformacije je spojina uporaben model za vpra\u0161anje, katere podstrukture velikega beljakovinskega hormona prena\u0161ajo katero interakcijo.<\/p>\n<p>V raziskovalnih modelih se fragment jasno razlikuje od celotne molekule somatotropina: ne aktivira klasi\u010dnega receptorja rastnega hormona, v predklini\u010dnih modelih pa fosforilacije STAT5 in indukcije IGF-1 nista opazili. In vitro pa se spojina preiskuje v modelih adipocitnih celic, s poudarkom na signalizaciji prek podtipov \u03b23-adrenergi\u010dnih receptorjev in povezane kaskade cAMP\/PKA. Zaradi te lo\u010ditve dveh signalnih poti znotraj ene same mati\u010dne molekule je fragment mehanisti\u010dno zanimiv. Posledi\u010dno se fragment HGH 176-191 uporablja kot modelna spojina in referen\u010dna snov v znanstvenih raziskavah.<\/p>\n<h2>Raziskovalna podro\u010dja<\/h2>\n<p>V laboratorijskem kontekstu se fragment HGH 176-191 pojavlja med drugim na naslednjih raziskovalnih podro\u010djih:<\/p>\n<ul>\n<li>Raziskave receptorjev podtipov \u03b23-adrenergi\u010dnih receptorjev in povezane signalizacije cAMP\/PKA v izoliranih celi\u010dnih modelih in vitro.<\/li>\n<li>Primerjalna \u0161tudija odpovedi receptorjev rastnega hormona, merjena s fosforilacijo STAT5 in indukcijo IGF-1 v predklini\u010dnih modelih.<\/li>\n<li>\u0160tudija strukture in aktivnosti o vlogi intramolekularnega disulfidnega mostu, pri kateri reducirane variante fragmenta slu\u017eijo kot kontrola.<\/li>\n<li>Modelne \u0161tudije presnove lipidov in spro\u0161\u010danja glicerola v gojenih adipocitih (vklju\u010dno s sistemi celi\u010dnih kultur 3T3-L1).<\/li>\n<li>Razvoj in validacija analitskih metod (HPLC, LC-MS, peptidno kartiranje), kjer fragment slu\u017ei kot referen\u010dni standard.<\/li>\n<li>\u0160tudije stabilnosti in topnosti kratkih peptidov, ki vsebujejo cistein, v nadzorovanih pogojih.<\/li>\n<\/ul>\n<p>Vsaka od teh aplikacij vklju\u010duje nadzorovane laboratorijske ali predklini\u010dne modelne raziskave.<\/p>\n<h2>HGH Fragment 176-191 in our research range<\/h2>\n<p>HGH Fragment 176-191 falls under the category of freeze-dried peptides in vials within our range. Researchers in this category regularly combine the compound with other peptides that are studied via their own biochemical target. While this fragment focuses on receptor signaling outside the classical growth hormone pathway, other components within the same product line have been specifically chosen to cover divergent receptor families or enzymatic pathways. These compounds share the freeze-dried form but differ fundamentally in amino acid sequence and investigated mechanism.<\/p>\n<h2>Specifikacije<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifikacija<\/th>\n<th>Vrednost<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorec<\/td>\n<td>HGH Fragment 176-191<\/td>\n<\/tr>\n<tr>\n<td>Sinonimi<\/td>\n<td>Somatotropin (176-191); hGH (176-191); hGH fragment 176-191<\/td>\n<\/tr>\n<tr>\n<td>\u0160tevilka CAS<\/td>\n<td>66004-57-7<\/td>\n<\/tr>\n<tr>\n<td>Molekulska formula \/ te\u017ea<\/td>\n<td>C<sub>78<\/sub>H<sub>123<\/sub>N<sub>23<\/sub>O<sub>22<\/sub>S<sub>2<\/sub> \/ 1799,1 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>16131230<\/td>\n<\/tr>\n<tr>\n<td>Razred<\/td>\n<td>Peptide fragment of sixteen amino acids, C-terminal part of somatotropin<\/td>\n<\/tr>\n<tr>\n<td>Oblika<\/td>\n<td>Lyophilisate (freeze-dried powder) in vial<\/td>\n<\/tr>\n<tr>\n<td>Koli\u010dina na vialo<\/td>\n<td>5 mg<\/td>\n<\/tr>\n<tr>\n<td>Shranjevanje<\/td>\n<td>Hranite v hladilniku, za\u0161\u010diteno pred svetlobo in vlago<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Oblika, ravnanje in shranjevanje<\/h2>\n<p>HGH Fragment 176-191 is supplied as a freeze-dried powder with a standardized quantity of 5 mg per vial. As with all lyophilized materials, the material is most stable in the dry state; for analytical work, it is dissolved in a laboratory setup with a suitable solvent. Cysteine-containing peptides are susceptible to oxidation in this process.<\/p>\n<p>Store the vial refrigerated, protected from direct light and moisture, in the original packaging. Observe the usual laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n<h2>Sestava in laboratorijski rezultati<\/h2>\n<p>For this compound, a controlled purity of \u2265 99% (HPLC) is maintained, as is customary for freeze-dried peptides serving as reference material.<\/p>\n<p>Pregled razpolo\u017eljive analiti\u010dne dokumentacije najdete na na\u0161i <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">stran z rezultati laboratorijskih preiskav<\/a>Poro\u010dila se tam zbirajo centralno, tako da lahko podatke vklju\u010dite v lastne raziskovalne evidence.<\/p>\n<h2>Pogosto zastavljena vpra\u0161anja<\/h2>\n<p><strong>To which class of substances does HGH Fragment 176-191 belong?<\/strong><br \/>It is a synthetic peptide of sixteen amino acids that corresponds to the C-terminal part of somatotropin. Therefore, not a small organic molecule, but a peptide fragment with a fixed sequence.<\/p>\n<p><strong>What is the difference compared to the modified analog AOD-9604?<\/strong><br \/>AOD-9604 is a distinct, modified variant with an extra tyrosine residue at the N-terminus. Both have been studied separately in the literature and are not treated as interchangeable in mechanistic laboratory research.<\/p>\n<p><strong>Why is the disulfide bridge important in research?<\/strong><br \/>The bridge between the two cysteine \u200b\u200bresidues determines the conformation of the fragment. In in vitro structure-activity studies, reduced variants in which that bridge is broken therefore serve as a control.<\/p>\n<p><strong>How do I store the bottle?<\/strong><br \/>Refrigerated, protected from light and moisture, preferably in the original packaging. Freeze-dried, the material is more stable than in solution.<\/p>","protected":false},"excerpt":{"rendered":"<p>Fragment HGH 176-191 je modificiran fragment rastnega hormona (aminokisline 176-191). V raziskavah ga preu\u010dujejo v modelih, ki vklju\u010dujejo lipolizo in presnovo ma\u0161\u010dob.<\/p>","protected":false},"featured_media":3248,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[117,121],"product_tag":[],"class_list":["post-2564","product","type-product","status-publish","has-post-thumbnail","product_cat-metabool-onderzoek","product_cat-peptides","first","outofstock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product\/2564","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/comments?post=2564"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product\/2564\/revisions"}],"predecessor-version":[{"id":2640,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product\/2564\/revisions\/2640"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/media\/3248"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/media?parent=2564"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product_brand?post=2564"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product_cat?post=2564"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sl\/wp-json\/wp\/v2\/product_tag?post=2564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}