Anastrozol 1 mg

Anastrozol je sintetična majhna molekula, ki spada v razred nesteroidnih zaviralcev encimov, kemično pa je derivat benzena s triazolilmetilno skupino in dvema terciarnima nitrilnima skupinama. V znanstvenih raziskavah se preučuje kot modelna spojina za razmerja med strukturo in aktivnostjo znotraj azolne serije ter kot referenčni standard pri analitičnem delu. Ta spojina je na voljo v obliki 1 mg tablet, izključno za laboratorijske in raziskovalne namene.

Kaj je anastrozol?

Anastrozol (2-[3-(2-cianopropan-2-il)-5-(1,2,4-triazol-1-ilmetil)fenil]-2-metilpropannitril) je strukturiran okoli simetrično 1,3,5-substituiranega benzenskega obroča: dve identični 2-cianopropan-2-ilni skupini in 1,2,4-triazolni obroč, povezani preko metilenskega mostu. Obe nitrilni funkciji sta vezani na popolnoma substituirane ogljikove atome, zaradi česar sta sterično zaščiteni in kemično nereaktivni. Poleg tega metilenski most daje triazolnemu obroču večjo svobodo gibanja kot v spojinah, kjer je azol neposredno vezan na metinski ogljik, kar je strukturna razlika, zaradi katere je molekula dragocena referenčna točka pri raziskavah strukture in aktivnosti.

V raziskovalnih modelih se obročni dušik triazola veže na hemsko železo v aktivni votlini encima aromataze (CYP19A1) in s tem reverzibilno izpodrine naravni substrat. Ker se ne tvori kovalentna vez, je inhibicija in vitro kompetitivna in popolnoma reverzibilna. Majhne razlike v prostorski orientaciji azola in v naravi stranskih skupin povzročijo merljivo različne konstante inhibicije znotraj serije, zaradi česar je spojina primerna za primerjalno kinetično delo. Posledično se anastrozol uporablja kot modelna spojina in referenčna snov v znanstvenih raziskavah.

Raziskovalna področja

V laboratorijskem kontekstu se anastrozol med drugim pojavlja na naslednjih raziskovalnih področjih:

• Raziskave encimske kinetike reverzibilne inhibicije CYP19A1 v mikrosomskih in rekombinantnih encimskih modelih.
• Študija strukture in aktivnosti znotraj serije triazolov, v kateri se dolžina mostu in velikost substituentov sistematično spreminjata.
• In vitro selectivity study of cross-reactivity with other cytochrome P450 isoforms.
• Raziskave pretvorbe steroidov in ravnovesja androgenov in estrogenov v modelih celičnih kultur.
• Razvoj in validacija analitskih metod (HPLC, LC-MS) z uporabo anastrozola kot kalibracijske snovi za določanje nizkih koncentracij.
• Stability and solubility studies of nitrile-substituted azole compounds under controlled conditions.

Vsaka od teh aplikacij vključuje nadzorovane laboratorijske ali predklinične modelne raziskave.

Anastrozol v našem raziskovalnem asortimanu

Anastrozole falls under the category of oral investigational compounds in solid tablet form within our range. Researchers working with this category regularly place the compound alongside other small molecules that are studied via their own biochemical target. While Anastrozole focuses on reversible, metal-coordinated enzyme inhibition, other components within the same product line have been specifically chosen to cover irreversible enzyme inactivation or receptor-linked targets. These compounds share the solid tablet form and the standardized amount of active substance per unit, but differ fundamentally in molecular class and the mechanism under investigation.

Specifikacije

Oblika, ravnanje in shranjevanje

Anastrozole is supplied as solid tablets with a standardized amount of 1 mg per tablet, packed in units of 100. With such a low concentration per unit, the majority of the tablet constitutes the excipient; therefore, in analytical work, multiple tablets are usually processed together and dissolved in a suitable analytical medium, after which the matrix components are separated by filtration or centrifugation.

Store the tablets dry at room temperature, protected from direct light and moisture, in the original packaging. The triazole ring and the shielded nitrile groups are chemically stable, but moisture absorption into the tablet matrix can affect the uniform distribution of the active substance. Handle the compound with the usual laboratory precautions: work in a clean environment, use suitable personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.

Sestava in laboratorijski rezultati

For this compound, the content is expressed as the amount of active substance per tablet (1 mg per tablet) rather than as a purity percentage, as is customary for tablet and capsule formulations. Especially at a low content per unit, the uniformity of that distribution is the determining specification.

Pregled razpoložljive analitične dokumentacije najdete na naši stran z rezultati laboratorijskih preiskavPoročila se tam zbirajo centralno, tako da lahko podatke vključite v lastne raziskovalne evidence.

Pogosto zastavljena vprašanja

To which class of substances does Anastrozole belong?
Anastrozole is a synthetic small molecule from the non-steroidal triazole series and is classified as a reversible aromatase inhibitor of type II. It is not a peptide and therefore contains no amino acid sequence.

How does the structure differ from other triazole compounds?
The triazole is coupled to the benzene ring via a methylene bridge rather than directly to a methine carbon. As a result, the ring has greater freedom of movement when approaching the heme iron, and the two sterically shielded nitrile groups contribute in their own way to the fit within the active cavity. This makes the compound a suitable reference point in structure-activity studies.

V kakšni obliki je dobavljena spojina?
As solid tablets with 1 mg active substance per tablet, packed in units of 100.

How do I store the tablets?
Dry, at room temperature and protected from light and moisture, preferably in the original packaging.