{"id":2955,"date":"2026-09-01T09:39:20","date_gmt":"2026-09-01T09:39:20","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2955"},"modified":"2026-09-02T12:16:28","modified_gmt":"2026-09-02T12:16:28","slug":"cjc-1295-met-dac-5mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/cjc-1295-met-dac-5mg\/","title":{"rendered":"CJC-1295 s DAC 5 mg"},"content":{"rendered":"<p>CJC-1295 s DAC je syntetick\u00fd, dlhodobo p\u00f4sobiaci anal\u00f3g horm\u00f3nu uvo\u013e\u0148uj\u00faceho rastov\u00fd horm\u00f3n (GHRH), ktor\u00fd patr\u00ed do triedy sekretag\u00f3gov rastov\u00e9ho horm\u00f3nu (molek\u00fal stimuluj\u00facich uvo\u013e\u0148ovanie). Od \u0161tandardnej formy sa l\u00ed\u0161i viazan\u00fdm komplexom s afinitou k lie\u010divu (DAC), \u010do je chemick\u00e1 skupina, ktor\u00e1 sa kovalentne via\u017ee na plazmatick\u00fd album\u00edn, \u010d\u00edm v\u00fdrazne predl\u017euje \u010das cirkul\u00e1cie molekuly. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa t\u00e1to zl\u00fa\u010denina \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina v okol\u00ed receptora GHRH a sign\u00e1lnej osi GH\/IGF-1. Ur\u010den\u00e9 v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je CJC-1295 s DAC?<\/h2>\n<p>CJC-1295 s DAC je skon\u0161truovan\u00fd okolo prv\u00fdch 29 aminokysel\u00edn \u013eudsk\u00e9ho GHRH \u2013 rovnakej peptidovej kostry ako Mod GRF 1-29 \u2013 s nieko\u013ek\u00fdmi aminokyselinov\u00fdmi substit\u00faciami, ktor\u00e9 zvy\u0161uj\u00fa molekul\u00e1rnu stabilitu. K tejto kostre je pripojen\u00e1 lyz\u00edn-maleimidopropionylov\u00e1 skupina: skuto\u010dn\u00fd komplex s afinitou k lie\u010divu. Zl\u00fa\u010deninu p\u00f4vodne op\u00edsala spolo\u010dnos\u0165 ConjuChem Biotechnologies a v literat\u00fare sa ozna\u010duje aj ako DAC:GRF. \u0160truktur\u00e1lne ide teda o anal\u00f3g GHRH(1-29) s fragmentom via\u017eucim album\u00edn, \u010do z nej rob\u00ed zauj\u00edmav\u00fa modelov\u00fa zl\u00fa\u010deninu pre v\u00fdskum dlhodobo p\u00f4sobiacich peptidov\u00fdch ch\u00e9mi.<\/p>\n<p>Na rozdiel od kr\u00e1tkeho, pulza\u010dn\u00e9ho \u00fa\u010dinku nemodifikovan\u00fdch fragmentov GHRH je CJC-1295 s DAC navrhnut\u00fd tak, aby zostal v roztoku pr\u00edtomn\u00fd dlh\u0161\u00ed \u010das. V\u010faka tomu je t\u00e1to zl\u00fa\u010denina vhodn\u00e1 ako referen\u010dn\u00fd model, ke\u010f chc\u00fa v\u00fdskumn\u00edci \u0161tudova\u0165 spr\u00e1vanie peptidov viazan\u00fdch na album\u00edn v porovnan\u00ed s ich kr\u00e1tkodobo p\u00f4sobiacimi n\u00e1protivkami.<\/p>\n<h2>Komplex afinity k liekom (DAC) je predmetom sk\u00famania<\/h2>\n<p>Charakteristick\u00fdm znakom tohto variantu je komplex s afinitou k lieku. Po uveden\u00ed peptidu do roztoku maleimidopropionylov\u00e1 skupina vytvor\u00ed kovalentn\u00fa v\u00e4zbu s vo\u013enou tiolovou skupinou na cirkuluj\u00facom album\u00edne. Preto\u017ee molekula je takto spojen\u00e1 s ve\u013ek\u00fdm nosi\u010dov\u00fdm prote\u00ednom, prote\u00e1zy ju pomal\u0161ie degraduj\u00fa a odstra\u0148uj\u00fa pomal\u0161ie. Vo v\u00fdskumn\u00fdch modeloch sa t\u00fdm efekt\u00edvny pol\u010das rozpadu pos\u00fava z r\u00e1du min\u00fat na nieko\u013eko dn\u00ed. Pre v\u00fdskumn\u00edkov je tento mechanizmus relevantn\u00fd ako \u0161tudijn\u00fd model pre strat\u00e9gie predl\u017euj\u00face pol\u010das rozpadu a pre porovn\u00e1vanie kontinu\u00e1lnej a pulzatilnej expoz\u00edcie receptorom.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<ul>\n<li>V\u00e4zba receptora GHRH a prenos sign\u00e1lu cAMP in vitro<\/li>\n<li>Farmakokinetika peptidov viazan\u00fdch na album\u00edn a mechanizmy pred\u013a\u017eenia pol\u010dasu rozpadu<\/li>\n<li>Porovn\u00e1vacia \u0161t\u00fadia kontinu\u00e1lnej a pulzatilnej aktiv\u00e1cie GHRH receptora<\/li>\n<li>Modelovanie sign\u00e1lnej osi GH\/IGF-1 v predklinick\u00fdch syst\u00e9moch<\/li>\n<li>Proteolytick\u00e1 a konforma\u010dn\u00e1 stabilita modifikovan\u00fdch anal\u00f3gov GHRH<\/li>\n<li>Porovn\u00e1vacie \u0161t\u00fadie receptorov s agonistami ghrel\u00ednov\u00fdch receptorov (trieda GHRP)<\/li>\n<\/ul>\n<h2>CJC-1295 s DAC v porovnan\u00ed s podobn\u00fdmi pripojeniami<\/h2>\n<p>V r\u00e1mci skupiny sekretag\u00f3gov rastov\u00e9ho horm\u00f3nu existuje viacero \u0161truktur\u00e1lne pr\u00edbuzn\u00fdch modelov\u00fdch zl\u00fa\u010den\u00edn, ktor\u00e9 sa \u010dasto \u0161tuduj\u00fa s\u00fabe\u017ene. Priamym n\u00e1protivkom je <a href=\"https:\/\/lumopeptides.com\/product\/cjc-1295-no-dac\/\" target=\"_blank\" rel=\"noopener\">CJC-1295 bez DAC (Mod GRF 1-29)<\/a>, ktor\u00fd zdie\u013ea rovnak\u00fd GHRH re\u0165azec, ale ch\u00fdba mu komplex via\u017euci album\u00edn, a preto m\u00e1 ove\u013ea krat\u0161\u00ed \u010das cirkul\u00e1cie. <a href=\"https:\/\/lumopeptides.com\/product\/tesamorelin\/\" target=\"_blank\" rel=\"noopener\">Tesamorel\u00edn<\/a> je \u010fal\u0161\u00ed stabilizovan\u00fd anal\u00f3g GHRH, zalo\u017een\u00fd na kompletnom fragmente GHRH(1-44) s N-termin\u00e1lnou acylovou skupinou, zatia\u013e \u010do <a href=\"https:\/\/lumopeptides.com\/product\/sermorelin-acetaat\/\" target=\"_blank\" rel=\"noopener\">Sermorel\u00edn<\/a> je presne jedn\u00fdm z najkrat\u0161\u00edch anal\u00f3gov GHRH a \u010dasto sl\u00fa\u017ei ako referencia. Samostatnou mechanistickou triedou s\u00fa agonisty ghrel\u00ednov\u00fdch receptorov, ako napr\u00edklad <a href=\"https:\/\/lumopeptides.com\/product\/ipamorelin\/\" target=\"_blank\" rel=\"noopener\">Ipamorel\u00edn<\/a>, ktor\u00e9 p\u00f4sobia na os GH prostredn\u00edctvom inej sign\u00e1lnej dr\u00e1hy a s\u00fa pravidelne modelovan\u00e9 spolu s anal\u00f3gmi GHRH v porovn\u00e1vacom v\u00fdskume.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>CJC-1295 s DAC (DAC:GRF)<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>CJC-1295 DAC, DAC:GRF<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C1\u2086\u2085H\u2082\u2086\u2089N\u20847O\u2084\u2086 \/ \u00b1 3647,9 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>91971820<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Dlhodobo p\u00f4sobiaci anal\u00f3g GHRH(1-29) s komplexom Drug Affinity Complex (sekretagog rastov\u00e9ho horm\u00f3nu)<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ok), 5 mg na injek\u010dn\u00fa liekovku<\/td>\n<\/tr>\n<tr>\n<td>\u010cistota<\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1\u0148te pred svetlom a vlhkos\u0165ou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Zl\u00fa\u010denina sa pon\u00faka v jednej injek\u010dnej liekovke obsahuj\u00facej 5 mg lyofilizovan\u00e9ho pr\u00e1\u0161ku (lyofiliz\u00e1tu). Lyofilizovan\u00fd pr\u00e1\u0161ok zost\u00e1va dlhodobo stabiln\u00fd pri skladovan\u00ed v chladnom, tmavom a vlhkom prostred\u00ed. Na pou\u017eitie vo v\u00fdskumnom prostred\u00ed sa lyofiliz\u00e1t rekon\u0161tituuje vhodn\u00fdm rozp\u00fa\u0161\u0165adlom, ako je bakteriostatick\u00e1 voda; pracujte sterilne a nechajte rozp\u00fa\u0161\u0165adlo jemne steka\u0165 po stene liekovky, a nie priamo na pr\u00e1\u0161ok. Po rekon\u0161tit\u00facii sa roztok uchov\u00e1va v chladni\u010dke (2 \u2013 8 \u00b0C) a chr\u00e1\u0148te pred svetlom. Vo v\u00fdskumn\u00fdch protokoloch sa opakovan\u00e9mu zmrazovaniu a rozmrazovaniu vo v\u0161eobecnosti vyh\u00fdba, aby sa zachovala konforma\u010dn\u00e1 integrita peptidu.<\/p>\n<h2>\u010cistota a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>CJC-1295 s DAC sa pon\u00faka s kontrolovanou \u010distotou \u2265 99 %, stanovenou pomocou HPLC. Aktu\u00e1lne certifik\u00e1ty anal\u00fdzy a \u00fadaje o \u010distote na\u0161ich zl\u00fa\u010den\u00edn si m\u00f4\u017eete pozrie\u0165 na <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Ak\u00fd je rozdiel medzi CJC-1295 s DAC a bez neho?<\/strong><br \/>Obe maj\u00fa rovnak\u00fd hlavn\u00fd re\u0165azec GHRH(1-29). Variant s DAC nesie extra komplex via\u017euci album\u00edn, \u010do sp\u00f4sobuje, \u017ee molekula zost\u00e1va v obehu ove\u013ea dlh\u0161ie vo v\u00fdskumn\u00fdch modeloch ako forma bez DAC.<\/p>\n<p><strong>\u010co znamen\u00e1 skratka DAC?<\/strong><br \/>DAC je skratka pre Drug Affinity Complex (komplex s afinitou k lieku): chemick\u00e1 skupina, ktor\u00e1 sa kovalentne via\u017ee na plazmatick\u00fd album\u00edn, a t\u00fdm oneskoruje kl\u00edrens peptidu.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) s hmotnos\u0165ou 5 mg na injek\u010dn\u00fa liekovku, ktor\u00fd sa pred pou\u017eit\u00edm vo v\u00fdskume rekon\u0161tituuje.<\/p>\n<p><strong>Ako sa skladuje?<\/strong><br \/>Lyofilizovan\u00fd pr\u00e1\u0161ok sa m\u00e1 uchov\u00e1va\u0165 v chlade, tme a suchu; po rekon\u0161tit\u00facii sa m\u00e1 uchov\u00e1va\u0165 v chladni\u010dke pri teplote 2 \u2013 8 \u00b0C a chr\u00e1ni\u0165 pred svetlom.<\/p>\n<p class=\"lumo-blogcta\"><strong>Chcete sa dozvedie\u0165 viac?<\/strong> Pre\u010d\u00edtajte si n\u00e1\u0161ho sprievodcu: <a href=\"https:\/\/lumopeptides.com\/hgh-peptiden-ghrh-ghrp-uitgelegd\/\" target=\"_blank\" rel=\"noopener\">Vysvetlenie HGH peptidov: anal\u00f3gy GHRH, GHRP a rozdiel od skuto\u010dn\u00e9ho rastov\u00e9ho horm\u00f3nu<\/a>.<\/p>\n<p><em>Ur\u010den\u00e9 v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely. Nie je ur\u010den\u00e9 na \u013eudsk\u00fa ani \u017eivo\u010d\u00ed\u0161nu spotrebu, ani na lek\u00e1rske, diagnostick\u00e9, terapeutick\u00e9 alebo kozmetick\u00e9 pou\u017eitie. Kupuj\u00faci m\u00e1 viac ako 18 rokov a potvrdzuje v\u00fdskumn\u00fd kontext. Nie je to liek.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p><strong>CJC-1295 s DAC \u2013 dlhodobo p\u00f4sobiaci anal\u00f3g GHRH s komplexom s afinitou k liekom<\/strong><br \/> CJC-1295 s DAC je syntetick\u00fd anal\u00f3g horm\u00f3nu uvo\u013e\u0148uj\u00faceho rastov\u00fd horm\u00f3n (GHRH) s unik\u00e1tnou modifik\u00e1ciou: Drug Affinity Complex (DAC). T\u00e1to \u00faprava zabezpe\u010duje, \u017ee sa peptid via\u017ee na album\u00edn v krvi, \u010d\u00edm sa predl\u017euje pol\u010das rozpadu na 6 a\u017e 8 dn\u00ed. V\u010faka tomu CJC-1295 s DAC stimuluje trval\u00e9, pulzuj\u00face uvo\u013e\u0148ovanie rastov\u00e9ho horm\u00f3nu z hypof\u00fdzy, \u010d\u00edm napodob\u0148uje fyziologick\u00e9 hormon\u00e1lne vzorce.<\/p>","protected":false},"featured_media":3246,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[124,121],"product_tag":[],"class_list":["post-2955","product","type-product","status-publish","has-post-thumbnail","product_cat-musculoskeletaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2955"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2955\/revisions"}],"predecessor-version":[{"id":3028,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2955\/revisions\/3028"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3246"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2955"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2955"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2955"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}