{"id":2947,"date":"2026-09-01T09:38:54","date_gmt":"2026-09-01T09:38:54","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2947"},"modified":"2026-09-02T12:17:48","modified_gmt":"2026-09-02T12:17:48","slug":"sermorelin-acetaat-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/sermorelin-acetaat-10mg\/","title":{"rendered":"Sermorel\u00edn acet\u00e1t 10 mg"},"content":{"rendered":"<p>Sermorel\u00edn acet\u00e1t je syntetick\u00fd polypeptid triedy anal\u00f3gov GHRH, chemicky acet\u00e1tov\u00e1 so\u013e re\u0165azca 29 aminokysel\u00edn s C-termin\u00e1lnou amidovou funkciou. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre farmakologick\u00fa anal\u00fdzu receptorov triedy B spojen\u00fdch s G-prote\u00ednom a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je sermorel\u00edn acet\u00e1t?<\/h2>\n<p>Sermorel\u00edn (hGHRH(1-29)NH)<sub>2<\/sub>) zodpoved\u00e1 N-termin\u00e1lnemu fragmentu prv\u00fdch 29 aminokysel\u00edn \u013eudsk\u00e9ho horm\u00f3nu uvo\u013e\u0148uj\u00faceho rastov\u00fd horm\u00f3n, endog\u00e9nneho polypeptidu so 44 zvy\u0161kami. Sekvencia znie Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH<sub>2<\/sub>V literat\u00fare sa tento fragment pova\u017euje za najkrat\u0161iu \u010das\u0165, ktor\u00e1 si zachov\u00e1va pln\u00e9 rozpozn\u00e1vanie receptorom; re\u0165azec sa sklad\u00e1 do amfipatickej alfa-helixu, ktorej hydrof\u00f3bna strana tvor\u00ed kontaktn\u00fd povrch. T\u00e1to kombin\u00e1cia kr\u00e1tkej sekvencie a neporu\u0161en\u00e9ho v\u00e4zbov\u00e9ho profilu rob\u00ed zo zl\u00fa\u010deniny \u0161iroko pou\u017e\u00edvan\u00fd \u0161truktur\u00e1lny model. Acet\u00e1t p\u00f4sob\u00ed ako protii\u00f3n.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa Sermorelin via\u017ee na receptor GHRH (GHRHR), \u010do je receptor spriahnut\u00fd s G-prote\u00ednom triedy B. V bunkov\u00fdch modeloch sa tento receptor via\u017ee prostredn\u00edctvom G1.<sub>s<\/sub> na adenyl\u00e1tcykl\u00e1zu, ktor\u00e1 in vitro vedie k tvorbe cAMP a aktiv\u00e1cii prote\u00ednkin\u00e1zy A; t\u00e1to kask\u00e1da je \u0161tandardn\u00fdm meradlom v receptorov\u00fdch testoch. Okrem toho je t\u00e1to zl\u00fa\u010denina klasick\u00fdm substr\u00e1tom pre enzymatick\u00fa pr\u00e1cu: dipeptidylpeptid\u00e1za-4 \u0161tiepi N-termin\u00e1lny dipeptid in vitro, po \u010dom zost\u00e1vaj\u00faci fragment vykazuje v\u00fdrazne zn\u00ed\u017een\u00fa afinitu k receptoru. V d\u00f4sledku toho sa sermorel\u00edn acet\u00e1t pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa Sermorel\u00edn acet\u00e1t vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>V\u00fdskum receptorov GHRH vr\u00e1tane v\u00e4zbov\u00fdch \u0161t\u00fadi\u00ed na izolovan\u00fdch bunkov\u00fdch modeloch in vitro.<\/li>\n<li>\u0160t\u00fadia sign\u00e1lnej transdukcie do G<sub>s<\/sub>aktiv\u00e1cia viazanej adenyl\u00e1tcykl\u00e1zy a tvorba cAMP v syst\u00e9moch bunkov\u00fdch kult\u00far.<\/li>\n<li>Enzymologick\u00e9 sk\u00famanie dipeptidylpeptid\u00e1zy-4 a \u0161tiepenia N-termin\u00e1lneho dipeptidu in vitro.<\/li>\n<li>\u0160t\u00fadia vz\u0165ahu medzi \u0161trukt\u00farou a aktivitou C-termin\u00e1lnej amidovej funkcie a jednotliv\u00fdch zvy\u0161kov v amfipatickej helixe.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm sermorel\u00edn acet\u00e1tu ako referen\u010dn\u00e9ho \u0161tandardu.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti lyofilizovan\u00fdch polypeptidov za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>Sermorel\u00edn acet\u00e1t v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>Sermorel\u00edn acet\u00e1t patr\u00ed v r\u00e1mci n\u00e1\u0161ho produktov\u00e9ho radu do kateg\u00f3rie lyofilizovan\u00fdch peptidov vo forme liekoviek. V\u00fdskumn\u00edci pravidelne kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi polypeptidmi, ktor\u00e9 s\u00fa \u0161tudovan\u00e9 prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do sermorel\u00edn acet\u00e1t sa zameriava na receptor spriahnut\u00fd s G-prote\u00ednom triedy B a s\u00favisiacu kask\u00e1du cAMP, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 tak, aby pokr\u00fdvali odli\u0161n\u00e9 rodiny receptorov alebo enzymatick\u00e9 dr\u00e1hy. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale l\u00ed\u0161ia sa zlo\u017een\u00edm aminokysel\u00edn a sk\u00faman\u00fdm mechanizmom.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>Sermorel\u00edn acet\u00e1t<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>hGHRH(1-29)NH<sub>2<\/sub>GRF(1-29)NH<sub>2<\/sub>Somatotrop\u00edn uvo\u013e\u0148uj\u00faci horm\u00f3n (1-29)amid<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>86168-78-7<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>149<\/sub>H<sub>246<\/sub>N<sub>44<\/sub>O<sub>42<\/sub>S \/ 3357,9 Da (vo\u013en\u00e1 b\u00e1za)<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>16132413<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd polypeptid, 29 aminokysel\u00edn, anal\u00f3g GHRH<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ok) v injek\u010dnej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Lyofilizovan\u00e9 skladujte na chladnom a tmavom mieste, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Sermorel\u00edn acet\u00e1t sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku. Lyofiliz\u00e1t je biely a\u017e sivobiely pr\u00e1\u0161kov\u00fd zvy\u0161ok na dne injek\u010dnej liekovky. Na rozdiel od pevn\u00fdch tabliet je materi\u00e1l v lyofilizovanom stave ur\u010den\u00fd na rozpustenie vo vhodnom rozp\u00fa\u0161\u0165adle v laborat\u00f3rnom zariaden\u00ed pred vykonan\u00edm analytick\u00fdch pr\u00e1c.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte na chladnom a tmavom mieste, chr\u00e1nenom pred svetlom a vlhkos\u0165ou, v p\u00f4vodnom obale. S pripojen\u00edm manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obmedzte kol\u00edsanie teploty. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t dosahuje kontrolovan\u00fa \u010distotu \u2265 99 % (HPLC). Injek\u010dn\u00e1 liekovka obsahuje polypeptid ako acet\u00e1tov\u00fa so\u013e bez pridan\u00fdch pomocn\u00fdch l\u00e1tok.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed Sermorel\u00edn acet\u00e1t?<\/strong><br \/>Sermorel\u00edn acet\u00e1t je syntetick\u00fd polypeptid z 29 aminokysel\u00edn s C-termin\u00e1lnou amidovou funkciou, klasifikovan\u00fd ako anal\u00f3g GHRH. Nie je to mal\u00e1 syntetick\u00e1 molekula, ale peptid s definovanou aminokyselinovou sekvenciou.<\/p>\n<p><strong>Pre\u010do je dipeptidylpeptid\u00e1za-4 relevantn\u00e1 vo v\u00fdskume s touto zl\u00fa\u010deninou?<\/strong><br \/>Vo v\u00fdskumn\u00fdch modeloch tento enz\u00fdm od\u0161tiepi N-termin\u00e1lny dipeptid z re\u0165azca. V\u00fdsledn\u00fd fragment vykazuje in vitro v\u00fdrazne zn\u00ed\u017een\u00fa afinitu k receptoru, v\u010faka \u010domu je t\u00e1to zl\u00fa\u010denina \u0161iroko pou\u017e\u00edvan\u00fdm referen\u010dn\u00fdm bodom v enzymologickom v\u00fdskume.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg v uzavretej injek\u010dnej liekovke, ur\u010den\u00fd na rozpustenie vo vhodnom rozp\u00fa\u0161\u0165adle v laborat\u00f3rnom prostred\u00ed.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chlade a tme, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou, najlep\u0161ie v p\u00f4vodnom obale.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"696\" data-end=\"748\">Sermorel\u00edn \u2013 peptid pre v\u00fdskumn\u00e9 aplik\u00e1cie<\/strong><br data-start=\"748\" data-end=\"751\" \/>Sermorel\u00edn je syntetick\u00fd peptid zalo\u017een\u00fd na fragmente prirodzene sa vyskytuj\u00facej molekuly horm\u00f3nu. Pou\u017e\u00edva sa v laborat\u00f3rnych a predklinick\u00fdch v\u00fdskumn\u00fdch modeloch, v ktor\u00fdch sa \u0161tuduj\u00fa vlastnosti peptidov, molekul\u00e1rne \u0161trukt\u00fary a interakcie receptorov. Sermorel\u00edn nie je medic\u00ednsky, farmaceutick\u00fd ani spotrebite\u013esk\u00fd v\u00fdrobok.<\/p>","protected":false},"featured_media":3256,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[124,121],"product_tag":[],"class_list":["post-2947","product","type-product","status-publish","has-post-thumbnail","product_cat-musculoskeletaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2947"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2947\/revisions"}],"predecessor-version":[{"id":3019,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2947\/revisions\/3019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3256"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2947"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2947"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2947"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}