{"id":2905,"date":"2026-09-01T09:35:26","date_gmt":"2026-09-01T09:35:26","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2905"},"modified":"2026-09-02T12:24:46","modified_gmt":"2026-09-02T12:24:46","slug":"kpv","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/kpv\/","title":{"rendered":"KPV"},"content":{"rendered":"<h2>\u010co je KPV?<\/h2>\n<p>KPV je syntetick\u00fd tripeptid: re\u0165azec troch aminokyselinov\u00fdch zvy\u0161kov so sekvenciou Lys-Pro-Val (lyz\u00edn-prol\u00edn-val\u00edn). Zl\u00fa\u010denina je zn\u00e1ma pod \u010d\u00edslom CAS 67727-97-3 s molekulov\u00fdm vzorcom C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub> (pribli\u017ene 342,44 Da) a PubChem CID 125672. S tromi zvy\u0161kami patr\u00ed KPV medzi najkrat\u0161ie mo\u017en\u00e9 oligopeptidy, a preto tvor\u00ed doln\u00fd limitn\u00fd pr\u00edpad triedy peptidov.<\/p>\n<p>\u0160trukt\u00fara je chemicky ostro definovan\u00e1: b\u00e1zick\u00fd lyz\u00ednov\u00fd bo\u010dn\u00fd re\u0165azec s vo\u013enou \u03b5-aminoskupinou na N-konci, centr\u00e1lny prol\u00edn, ktor\u00fd obmedzuje rota\u010dn\u00fa slobodu okolo susednej peptidovej v\u00e4zby, a nepol\u00e1rny val\u00edn na C-konci. V d\u00f4sledku toho molekula nesie kladne nabit\u00fa aj nepol\u00e1rnu \u010das\u0165 iba na troch poz\u00edci\u00e1ch. Pr\u00e1ve t\u00e1to kombin\u00e1cia kr\u00e1tkej d\u013a\u017eky re\u0165azca, vysokej polarity a cis\/trans-izomerizovate\u013enej v\u00e4zby X-Pro rob\u00ed z KPV mimoriadne vhodn\u00fd model pre v\u00fdvoj met\u00f3d: kr\u00e1tke re\u0165azce vykazuj\u00fa takmer \u017eiadnu retenciu na \u0161tandardn\u00fdch kol\u00f3nach s reverznou f\u00e1zou a vyplavuj\u00fa sa bl\u00edzko m\u0155tveho objemu, \u010do z tejto zl\u00fa\u010deniny rob\u00ed pr\u00edsny testovac\u00ed pr\u00edpad pre v\u00fdber kol\u00f3ny, i\u00f3novo-p\u00e1rovacie \u010dinidl\u00e1 a podmienky HILIC. Okrem toho skuto\u010dnos\u0165, \u017ee KPV neobsahuje \u017eiadne aromatick\u00e9 zvy\u0161ky, a preto takmer v\u00f4bec neabsorbuje nad 220 nm, z neho rob\u00ed u\u017eito\u010dn\u00fd model pre detek\u010dn\u00e9 probl\u00e9my zah\u0155\u0148aj\u00face slabo UV-akt\u00edvne peptidy.<\/p>\n<h2>Aplik\u00e1cie v laborat\u00f3rnom kontexte<\/h2>\n<p>V r\u00e1mci peptidovej ch\u00e9mie a analytick\u00fdch pr\u00e1c sa KPV vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdskum vz\u0165ahu \u0161trukt\u00fary a aktivity<\/strong> \u010do sa t\u00fdka samostatn\u00e9ho pr\u00edspevku b\u00e1zick\u00fdch, rigidiza\u010dn\u00fdch a nepol\u00e1rnych pol\u00f4h k rozlo\u017eeniu n\u00e1boja, polarite a reten\u010dn\u00e9mu spr\u00e1vaniu ve\u013emi kr\u00e1tkych re\u0165azcov.<\/li>\n<li><strong>V\u00fdskum peptidovej ch\u00e9mie<\/strong> smerom k rozpustnosti a konforma\u010dn\u00e9mu spr\u00e1vaniu tripeptidov, vr\u00e1tane pomeru cis\/trans okolo v\u00e4zby Lys-Pro monitorovan\u00e9ho pomocou NMR spektroskopie.<\/li>\n<li><strong>\u0160t\u00fadie enzymatickej stability<\/strong> v ktorom sa ur\u010duje, ako zle sa v\u00e4zby X-Pro \u0161tiepia v\u00e4\u010d\u0161inou prote\u00e1z za definovan\u00fdch podmienok, pri\u010dom tripeptid sl\u00fa\u017ei ako jednoduch\u00fd referen\u010dn\u00fd bod.<\/li>\n<li><strong>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d<\/strong> (HPLC, LC-MS, mapovanie peptidov), v ktor\u00fdch s\u00fa optimalizovan\u00e9 reten\u010dn\u00e9 parametre, tvar p\u00edku a detek\u010dn\u00fd limit n\u00edzkomolekul\u00e1rnych pol\u00e1rnych peptidov, s derivatiz\u00e1ciou alebo hmotnostnou spektrometriou ako alternat\u00edvou k UV \u017eiareniu.<\/li>\n<\/ul>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Vzorka<\/strong><\/td>\n<td>KPV (syntetick\u00fd tripeptid), lyofilizovan\u00fd v uzavretej liekovke<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u013a\u017eka peptidu<\/strong><\/td>\n<td>3 aminokyselinov\u00e9 zvy\u0161ky<\/td>\n<\/tr>\n<tr>\n<td><strong>Postupnos\u0165<\/strong><\/td>\n<td>Lys-Pro-Val (lyz\u00edn-prol\u00edn-val\u00edn)<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>67727-97-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/strong><\/td>\n<td>C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub> \/ pribli\u017ene 342,44 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>Trieda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rny tripeptid (kr\u00e1tky modelov\u00fd oligopeptid)<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1r<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofilizovan\u00fd pr\u00e1\u0161ok) v uzavretej sklenenej liekovke<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladovanie<\/strong><\/td>\n<td>Lyofilizovan\u00e9 pri teplote 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Materi\u00e1l sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofilizovan\u00fd pr\u00e1\u0161ok), bielej a\u017e sivobielej farby, v uzavretej sklenenej liekovke s gumenou priehradkou a hlin\u00edkov\u00fdm zmr\u0161\u0165ovac\u00edm uz\u00e1verom. Kr\u00e1tke, vysoko pol\u00e1rne peptidy s\u00fa v\u00fdrazne hygroskopick\u00e9; preto liekovka zost\u00e1va uzavret\u00e1 v p\u00f4vodnom obale, k\u00fdm sa vzorka nespracuje v laborat\u00f3riu, preto\u017ee absorbovan\u00e1 vlhkos\u0165 m\u00e1 pri stanoven\u00ed hmotnosti pri n\u00edzkej molekulovej hmotnosti relat\u00edvne ve\u013ek\u00fa v\u00e1hu.<\/p>\n<p>Utesnen\u00fa liekovku skladujte lyofilizovan\u00fa pri teplote 2 \u2013 8 \u00b0C na tmavom a suchom mieste. Okrem toho platia be\u017en\u00e9 laborat\u00f3rne opatrenia: pracujte v \u010distom a suchom prostred\u00ed, pred otvoren\u00edm nechajte liekovku dosiahnu\u0165 izbov\u00fa teplotu, aby ste predi\u0161li kondenz\u00e1cii, a zaznamenajte \u010d\u00edslo \u0161ar\u017ee a d\u00e1tum otvorenia ka\u017edej liekovky do laborat\u00f3rneho z\u00e1znamu, aby sa s\u00e9ria meran\u00ed nesk\u00f4r dala vysledova\u0165.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>Pri tripeptide je len mal\u00fd priestor pre neistotu vo v\u00fdchodiskovej l\u00e1tke: ved\u013eaj\u0161ie produkty synt\u00e9zy a vo\u013en\u00e9 aminokyseliny sa molekulovou hmotnos\u0165ou bl\u00ed\u017eia k hlavnej zlo\u017eke a m\u00f4\u017eu sa zhodova\u0165 s hlavn\u00fdm p\u00edkom v chromatograme. N\u00e1\u0161 KPV sa dod\u00e1va s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v s\u00falade s pr\u00edslu\u0161n\u00fdm analytick\u00fdm certifik\u00e1tom. Dostupn\u00e9 analytick\u00e9 certifik\u00e1ty si m\u00f4\u017eete pozrie\u0165 na na\u0161ej webovej str\u00e1nke. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>D\u00f4le\u017eit\u00e9 vyhl\u00e1senie o vyl\u00fa\u010den\u00ed zodpovednosti<\/h2>\n<p>Tento produkt dod\u00e1vame v\u00fdhradne na laborat\u00f3rny v\u00fdskum a analytick\u00e9 pr\u00e1ce. Nie je ur\u010den\u00fd na diagnostick\u00e9 ani terapeutick\u00e9 aplik\u00e1cie a v\u00fdslovne nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed alebo zvierat. Tento produkt nie je potravinou, doplnkom stravy, kozmetick\u00fdm v\u00fdrobkom ani registrovan\u00fdm liekom. K\u00fapou tohto produktu kupuj\u00faci potvrdzuje, \u017ee m\u00e1 18 rokov alebo viac a bude ho pou\u017e\u00edva\u0165 v\u00fdlu\u010dne v kontrolovanom v\u00fdskumnom alebo laborat\u00f3rnom prostred\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>KPV je syntetick\u00fd tripeptid so sekvenciou Lys-Pro-Val (C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub>, pribli\u017ene 342,44 Da), v ktorom centr\u00e1lny prol\u00edn obmedzuje rota\u010dn\u00fa vo\u013enos\u0165 okolo susednej peptidovej v\u00e4zby. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina v peptidovej ch\u00e9mii a analytick\u00fdch pr\u00e1cach. Ur\u010den\u00e9 v\u00fdlu\u010dne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie na pou\u017eitie u \u013eud\u00ed alebo zvierat. Nie je to liek.<\/p>","protected":false},"featured_media":3228,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[125,121],"product_tag":[],"class_list":["post-2905","product","type-product","status-publish","has-post-thumbnail","product_cat-herstel-reparatie","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2905"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2905\/revisions"}],"predecessor-version":[{"id":2985,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2905\/revisions\/2985"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3228"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2905"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2905"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2905"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}