{"id":2900,"date":"2026-09-01T09:35:05","date_gmt":"2026-09-01T09:35:05","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2900"},"modified":"2026-09-02T12:15:40","modified_gmt":"2026-09-02T12:15:40","slug":"ara-290-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/ara-290-vial-10-mg\/","title":{"rendered":"Ara-290 injek\u010dn\u00e1 liekovka 10 mg"},"content":{"rendered":"<p>Ara-290 je syntetick\u00fd v\u00fdskumn\u00fd peptid, chemicky line\u00e1rny undekapeptid odvoden\u00fd z B-helixovej dom\u00e9ny erytropoet\u00ednu. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre receptorov\u00fa a cytok\u00ednov\u00fa signaliz\u00e1ciu a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je Ara-290?<\/h2>\n<p>Ara-290 (L-pyroglutamyl-L-glutamyl-L-glutaminyl-L-leucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-ser\u00edn) je line\u00e1rny peptid pozost\u00e1vaj\u00faci z jeden\u00e1stich aminokysel\u00edn so sekvenciou Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. Re\u0165azec je modelovan\u00fd pod\u013ea vonkaj\u0161ieho povrchu \u03b2-helixu erytropoet\u00ednu, \u010do v literat\u00fare vynieslo zl\u00fa\u010denine ozna\u010denie pyroglutam\u00e1t-helix-\u03b2-povrchov\u00fd-peptid (pHBSP). N-termin\u00e1lny pyroglutam\u00e1t ukon\u010duje aminoskupinu re\u0165azca, \u010do je \u0161truktur\u00e1lny znak, v\u010faka ktor\u00e9mu je peptid menej n\u00e1chyln\u00fd na degrad\u00e1ciu aminopeptid\u00e1zami in vitro. V\u010faka tomu je Ara-290 u\u017eito\u010dn\u00fdm modelom pri \u0161t\u00fadiu rozpozn\u00e1vania peptidov\u00fdch receptorov.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa Ara-290 nevia\u017ee na klasick\u00fd homodim\u00e9rny erytropoet\u00ednov\u00fd receptor, ale selekt\u00edvne na heterom\u00e9rny receptorov\u00fd komplex zlo\u017een\u00fd z EPO receptora (EPOR) a spolo\u010dn\u00e9ho beta re\u0165azca CD131 (\u03b2cR). Tento komplex sa vo vedeckej literat\u00fare ozna\u010duje ako vroden\u00fd opravn\u00fd receptor (IRR). V d\u00f4sledku toho sa v bunkov\u00fdch modeloch m\u00f4\u017ee peptid pou\u017ei\u0165 na \u0161t\u00fadium oboch sign\u00e1lnych dr\u00e1h samostatne. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa Ara-290 preto pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa Ara-290 vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>V\u00fdskum receptorov heterom\u00e9ru EPOR\/CD131 a jeho porovnanie s homodim\u00e9rnym EPO receptorom v kultivovan\u00fdch bunkov\u00fdch l\u00edni\u00e1ch.<\/li>\n<li>V\u00fdskum intracelul\u00e1rnej sign\u00e1lnej transdukcie (vr\u00e1tane dr\u00e1h JAK2\/STAT a PI3K\/Akt) po v\u00e4zbe na receptor in vitro.<\/li>\n<li>\u0160t\u00fadia vz\u0165ahu medzi \u0161trukt\u00farou a aktivitou, v ktorej sa menia jednotliv\u00e9 polohy aminokysel\u00edn undekapeptidu.<\/li>\n<li>Biofyzik\u00e1lne modelov\u00e9 \u0161t\u00fadie peptidov\u00fdch fragmentov, ktor\u00e9 napodob\u0148uj\u00fa helik\u00e1lny povrch v\u00e4\u010d\u0161ieho prote\u00ednu.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm Ara-290 ako referen\u010dn\u00e9ho \u0161tandardu.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti kr\u00e1tkych line\u00e1rnych peptidov s blokovan\u00fdm N-koncom za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>Ara-290 v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>V r\u00e1mci n\u00e1\u0161ho sortimentu spad\u00e1 Ara-290 do kateg\u00f3rie lyofilizovan\u00fdch v\u00fdskumn\u00fdch peptidov vo forme liekoviek. V\u00fdskumn\u00edci pravidelne kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi peptidmi, ktor\u00e9 s\u00fa \u0161tudovan\u00e9 prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do Ara-290 cieli na heterom\u00e9rny receptorov\u00fd komplex z rodiny cytok\u00ednov\u00fdch receptorov, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 tak, aby pokr\u00fdvali odli\u0161n\u00e9 rodiny receptorov alebo \u0161truktur\u00e1lne mot\u00edvy. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia v aminokyselinovej sekvencii, molekulovej ve\u013ekosti a sk\u00famanom mechanizme.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>Ara-290<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Cibinetid; povrchov\u00fd peptid pyroglutam\u00e1t helixu B (pHBSP); ARA290<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>1208243-50-8<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>51<\/sub>H<sub>84<\/sub>N<sub>16<\/sub>O<sub>21<\/sub> \/ 1257,3 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>91810664<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd line\u00e1rny peptid (undekapeptid), odvoden\u00fd z \u03b2-helixov\u00e9ho povrchu erytropoet\u00ednu<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v injek\u010dnej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Lyofilizovan\u00e9 skladujte na chladnom a tmavom mieste; pre dlh\u0161ie skladovanie pri teplote -20 \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Ara-290 sa dod\u00e1va ako lyofilizovan\u00fd biely a\u017e sivobiely pr\u00e1\u0161ok so \u0161tandardizovan\u00fdm mno\u017estvom 10 mg na injek\u010dn\u00fa liekovku. Na rozdiel od pevnej tablety ide o lyofiliz\u00e1t: pred analytickou pr\u00e1cou sa materi\u00e1l rozpust\u00ed v z\u00e1vislosti od vlastn\u00e9ho protokolu laborat\u00f3ria. Lyofilizovan\u00fd pr\u00e1\u0161ok je hygroskopick\u00fd a mal by by\u0165 vystaven\u00fd okolit\u00e9mu vzduchu \u010do najkrat\u0161\u00ed \u010das.<\/p>\n<p>Neotvoren\u00fa injek\u010dn\u00fa liekovku skladujte na chladnom a suchom mieste chr\u00e1nenom pred priamym svetlom v p\u00f4vodnom obale; pre dlh\u0161ie skladovanie je obvykl\u00e9 mrazenie pri teplote -20 \u00b0C. Zlo\u017eenie pozorujte pod\u013ea be\u017en\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Pri tomto lyofiliz\u00e1te sa dodr\u017eiava kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC). Uveden\u00e9 mno\u017estvo 10 mg sa vz\u0165ahuje na samotn\u00fd peptid bez pridan\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tok.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy prachu patr\u00ed Ara-290?<\/strong><br \/>Ara-290 je syntetick\u00fd line\u00e1rny peptid z jeden\u00e1stich aminokysel\u00edn (undekapeptid) so sekvenciou Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. Nie je to mal\u00e1 organick\u00e1 molekula, ale peptidov\u00fd fragment, ktor\u00fd napodob\u0148uje povrch glykoprote\u00ednu erytropoet\u00ednu.<\/p>\n<p><strong>\u010co sa vo v\u00fdskume rozumie pod pojmom vroden\u00fd opravn\u00fd receptor?<\/strong><br \/>V literat\u00fare sa to vz\u0165ahuje na heterom\u00e9rny receptorov\u00fd komplex EPO receptora (EPOR) a spolo\u010dn\u00e9ho beta re\u0165azca CD131. V bunkov\u00fdch modeloch Ara-290 cieli na tento komplex a nie na homodim\u00e9rny EPO receptor, \u010do umo\u017e\u0148uje rozl\u00ed\u0161i\u0165 obe sign\u00e1lne dr\u00e1hy in vitro.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok v injek\u010dnej liekovke obsahuj\u00facej 10 mg peptidu. Lyofiliz\u00e1t sa pred analytick\u00fdm pou\u017eit\u00edm rozpust\u00ed.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Lyofilizovan\u00e9, v chlade, suchu a chr\u00e1nen\u00e9 pred svetlom v p\u00f4vodnom obale; pre dlh\u0161ie skladovanie pri teplote -20 \u00b0C.<\/p>","protected":false},"excerpt":{"rendered":"<p data-start=\"743\" data-end=\"1147\"><strong data-start=\"743\" data-end=\"792\">ARA-290 \u2013 Peptid pre v\u00fdskumn\u00e9 aplik\u00e1cie<\/strong><br data-start=\"792\" data-end=\"795\" \/>ARA-290 je syntetick\u00fd peptid z 11 aminokysel\u00edn, zalo\u017een\u00fd na \u0161pecifickej \u0161truktur\u00e1lnej dom\u00e9ne prirodzene sa vyskytuj\u00faceho prote\u00ednu. Pou\u017e\u00edva sa v laborat\u00f3rnych a predklinick\u00fdch v\u00fdskumn\u00fdch prostrediach na \u0161t\u00fadium vlastnost\u00ed peptidov, interakci\u00ed receptorov a molekul\u00e1rnej stability. ARA-290 nie je spotrebite\u013esk\u00fd ani zdravotn\u00edcky produkt.<\/p>\n<h3 data-start=\"1149\" data-end=\"1176\"><\/h3>","protected":false},"featured_media":3241,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[125,121],"product_tag":[],"class_list":["post-2900","product","type-product","status-publish","has-post-thumbnail","product_cat-herstel-reparatie","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2900"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2900\/revisions"}],"predecessor-version":[{"id":2978,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2900\/revisions\/2978"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3241"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2900"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2900"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2900"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}