{"id":2867,"date":"2026-09-01T09:32:43","date_gmt":"2026-09-01T09:32:43","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2867"},"modified":"2026-09-02T12:15:01","modified_gmt":"2026-09-02T12:15:01","slug":"thymosin-alpha-1-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/thymosin-alpha-1-vial-10-mg\/","title":{"rendered":"Thymosin Alpha-1 injek\u010dn\u00e1 liekovka 10 mg"},"content":{"rendered":"<p>Tymoz\u00edn alfa-1 je syntetick\u00fd polypeptid z triedy tymick\u00fdch peptidov, chemicky line\u00e1rny, N-termin\u00e1lne acetylovan\u00fd peptid s 28 aminokyselinami. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre receptorom sprostredkovan\u00fa sign\u00e1lnu transdukciu a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je tymoz\u00edn alfa-1?<\/h2>\n<p>Tymoz\u00edn alfa-1 (tymalfaz\u00edn, T\u03b11) je polypeptid so sekvenciou Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, ktor\u00e1 \u0161truktur\u00e1lne zodpoved\u00e1 N-termin\u00e1lnemu fragmentu prekurzorov\u00e9ho prote\u00ednu protymoz\u00ednu alfa (113 aminokysel\u00edn). Molekula m\u00e1 silne kysl\u00fd charakter v\u010faka vysok\u00e9mu podielu zvy\u0161kov kyseliny glut\u00e1movej a kyseliny aspar\u00e1govej a neobsahuje cyste\u00edn, a teda ani disulfidov\u00e9 most\u00edky. T\u00e1to \u0161trukt\u00fara \u2013 kr\u00e1tky, neviazan\u00fd re\u0165azec bez terci\u00e1rnej skladacej \u0161trukt\u00fary s definovanou chemickou modifik\u00e1ciou \u2013 rob\u00ed z tejto zl\u00fa\u010deniny reprodukovate\u013en\u00fd model v peptidovej ch\u00e9mii a v\u00fdskume \u0161trukt\u00fary a aktivity.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa tymoz\u00edn alfa-1 prim\u00e1rne sk\u00fama kv\u00f4li jeho interakcii s Toll-like receptormi, najm\u00e4 TLR2 a TLR9, na izolovan\u00fdch myeloidn\u00fdch bunk\u00e1ch. In vitro bolo op\u00edsan\u00e9, \u017ee t\u00e1to v\u00e4zba na receptor moduluje sign\u00e1lne dr\u00e1hy downstream, vr\u00e1tane NF-\u03baB, p38 MAPK a IRF3, a \u017ee v bunkov\u00fdch modeloch je katabolizmus tryptof\u00e1nu ovplyvnen\u00fd enz\u00fdmom indoleam\u00edn-2,3-dioxygen\u00e1zou (IDO). N-termin\u00e1lna acetyl\u00e1cia sa jav\u00ed ako ur\u010duj\u00faci faktor pre stupe\u0148 interakcie receptorov v bunkov\u00fdch modeloch, \u010do umo\u017e\u0148uje porovn\u00e1vac\u00ed v\u00fdskum s neacetylovan\u00fdmi anal\u00f3gmi. V d\u00f4sledku toho sa tymoz\u00edn alfa-1 pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa tymoz\u00edn alfa-1 vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>V\u00fdskum receptorov podobn\u00fdch Tollu (TLR2 a TLR9) a s\u00favisiacej afinity ligand-receptor v izolovan\u00fdch bunkov\u00fdch modeloch in vitro.<\/li>\n<li>Enzymologick\u00fd v\u00fdskum modul\u00e1cie katabolizmu indoleam\u00edn-2,3-dioxygen\u00e1zy a tryptof\u00e1nu v syst\u00e9moch bunkov\u00fdch kult\u00far.<\/li>\n<li>V\u00fdskum intracelul\u00e1rnej sign\u00e1lnej transdukcie s kask\u00e1dami sprostredkovan\u00fdmi NF-\u03baB-, p38-MAPK- a IRF3 ako v\u00fdstupn\u00fdmi parametrami.<\/li>\n<li>V\u00fdskum \u0161trukt\u00fary a aktivity zameran\u00fd na \u00falohu N-termin\u00e1lnej acetyl\u00e1cie a kysl\u00fdch aminokyselinov\u00fdch zvy\u0161kov v kr\u00e1tkych peptidov\u00fdch re\u0165azcoch.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS, anal\u00fdza aminokysel\u00edn) s pou\u017eit\u00edm tymoz\u00ednu alfa-1 ako referen\u010dn\u00e9ho \u0161tandardu.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti lyofilizovan\u00fdch polypeptidov za kontrolovan\u00fdch podmienok teploty a pH.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>Tymoz\u00edn alfa-1 v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>Tymoz\u00edn Alpha-1 patr\u00ed v r\u00e1mci n\u00e1\u0161ho produktov\u00e9ho radu do kateg\u00f3rie lyofilizovan\u00fdch peptidov vo forme liekoviek. Zatia\u013e \u010do t\u00e1to zl\u00fa\u010denina cieli na sign\u00e1lnu transdukciu sprostredkovan\u00fa receptormi prostredn\u00edctvom Toll-like receptorov, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli \u0161peci\u00e1lne vybran\u00e9 na pokrytie enzymatick\u00fdch, rastovo faktormi viazan\u00fdch alebo membr\u00e1novo viazan\u00fdch cie\u013eov. Tieto zl\u00fa\u010deniny maj\u00fa rovnak\u00fa lyofilizovan\u00fa formu liekoviek a s\u00favisiace po\u017eiadavky na manipul\u00e1ciu, ale z\u00e1sadne sa l\u00ed\u0161ia v aminokyselinovej sekvencii, molekulovej ve\u013ekosti a sk\u00famanom mechanizme.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>Tymoz\u00edn alfa-1<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>tymalfas\u00edn; Ta1; Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>62304-98-7<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>129<\/sub>H<sub>215<\/sub>N<sub>33<\/sub>O<sub>55<\/sub> \/ 3108,3 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>16130571<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd polypeptid (28 aminokysel\u00edn), tymick\u00fd peptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v injek\u010dnej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Lyofilizovan\u00e9, skladujte na chladnom a suchom mieste, chr\u00e1nen\u00e9 pred svetlom; dlhodob\u00e9 skladovanie pri teplote -20 \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Thymosin Alpha-1 sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok so \u0161tandardizovan\u00fdmi 10 mg na injek\u010dn\u00fa liekovku. Na rozdiel od pevn\u00fdch tabliet ide o lyofiliz\u00e1t: materi\u00e1l sa pred analytickou pr\u00e1cou umiestni do vhodn\u00e9ho rozp\u00fa\u0161\u0165adla. Pr\u00e1\u0161ok m\u00f4\u017ee le\u017ea\u0165 ako tenk\u00e1 vrstva alebo sypk\u00fd kol\u00e1\u010d na dne alebo na stene injek\u010dnej liekovky; to je vlastn\u00e9 procesu lyofiliz\u00e1cie.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte na chladnom a suchom mieste chr\u00e1nenom pred priamym svetlom v p\u00f4vodnom obale; pre dlhodob\u00e9 skladovanie je obvykl\u00e1 teplota -20 \u00b0C. So zl\u00fa\u010deninou manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 ochrann\u00e9 prostriedky, vyh\u00fdbajte sa opakovan\u00fdm zmen\u00e1m teploty a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t m\u00e1 kontrolovan\u00fa \u010distotu \u2265 99 % (HPLC). Injek\u010dn\u00e1 liekovka obsahuje lyofilizovan\u00fd polypeptid bez pridan\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tok; m\u00f4\u017eu by\u0165 pr\u00edtomn\u00e9 zvy\u0161ky tlmiv\u00fdch sol\u00ed z v\u00fdrobn\u00e9ho procesu, ako je be\u017en\u00e9 pri synteticky pripraven\u00fdch peptidoch.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam centr\u00e1lne zhroma\u017e\u010fuj\u00fa pre va\u0161e vlastn\u00e9 v\u00fdskumn\u00e9 z\u00e1znamy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed tymoz\u00edn alfa-1?<\/strong><br \/>Je to syntetick\u00fd polypeptid z 28 aminokysel\u00edn z triedy tymick\u00fdch peptidov: nie mal\u00e1 organick\u00e1 molekula, ale line\u00e1rny re\u0165azec aminokysel\u00edn s acetylovou skupinou na N-konci.<\/p>\n<p><strong>Ak\u00fa \u00falohu hr\u00e1 protymoz\u00edn alfa vo v\u00fdskume?<\/strong><br \/>Tymoz\u00edn alfa-1 je sekven\u010dne zhodn\u00fd s N-termin\u00e1lnou oblas\u0165ou protymoz\u00ednu alfa, prekurzorov\u00e9ho prote\u00ednu so 113 aminokyselinami. Vo v\u00fdskumn\u00fdch modeloch sa tento vz\u0165ah pou\u017e\u00edva na ur\u010denie, ktor\u00e1 \u010das\u0165 re\u0165azca je zodpovedn\u00e1 za pozorovan\u00fa interakciu receptora in vitro.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) s hmotnos\u0165ou 10 mg v uzavretej injek\u010dnej liekovke s \u010distotou \u2265 99 % (HPLC).<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chlade, suchu a chr\u00e1nen\u00e9 pred svetlom, najlep\u0161ie v p\u00f4vodnom obale. Pre dlhodob\u00e9 skladovanie sa zvy\u010dajne udr\u017eiava teplota -20 \u00b0C.<\/p>","protected":false},"excerpt":{"rendered":"<p>Lyofilizovan\u00fd tymoz\u00edn alfa-1 (tymalfas\u00edn, T\u03b11), syntetick\u00fd peptid s 28 aminokyselinami \u2013 \u010distota \u226599 % (HPLC). Ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie je ur\u010den\u00fd na \u013eudsk\u00fa ani \u017eivo\u010d\u00ed\u0161nu spotrebu. Nie je to liek.<\/p>","protected":false},"featured_media":3235,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2867","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2867"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2867\/revisions"}],"predecessor-version":[{"id":2940,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2867\/revisions\/2940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3235"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2867"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2867"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2867"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}