{"id":2862,"date":"2026-09-01T09:32:13","date_gmt":"2026-09-01T09:32:13","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2862"},"modified":"2026-09-02T12:19:00","modified_gmt":"2026-09-02T12:19:00","slug":"aicar-50mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/aicar-50mg\/","title":{"rendered":"Aicar 50 mg"},"content":{"rendered":"<p>AICAR je syntetick\u00fd nukleozidov\u00fd anal\u00f3g, chemicky imidazol-4-karboxamid ribonukleozid. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre bioch\u00e9miu AMP-aktivovanej prote\u00ednkin\u00e1zy (AMPK) a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je AICAR?<\/h2>\n<p>AICAR (5-amino-1-\u03b2-D-ribofuranosylimidazol-4-karboxamid), v literat\u00fare tie\u017e ozna\u010dovan\u00fd ako akadez\u00edn alebo AICA ribozid, je mal\u00e1 organick\u00e1 molekula zlo\u017een\u00e1 z imidazol-4-karboxamidov\u00e9ho jadra spojen\u00e9ho s rib\u00f3zovou jednotkou. T\u00e1to \u0161trukt\u00fara z neho form\u00e1lne rob\u00ed nukleozidov\u00fd anal\u00f3g: \u0161trukt\u00fara napodob\u0148uje ribonukleozidov\u00fa architekt\u00faru prirodzen\u00fdch pur\u00ednov\u00fdch stavebn\u00fdch blokov, ale l\u00ed\u0161i sa heterocyklickou hlavou. T\u00e1to kombin\u00e1cia \u2013 rozpoznate\u013en\u00e1 u nukleozidov\u00fdch transport\u00e9rov a kin\u00e1z, ale s inou b\u00e1zovou skupinou \u2013 rob\u00ed z tejto zl\u00fa\u010deniny \u0161iroko pou\u017e\u00edvan\u00fd model pri \u0161t\u00fadiu metabolizmu nukleotidov a regul\u00e1cie kin\u00e1z.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sl\u00fa\u017ei samotn\u00fd AICAR ako v\u00fdchodiskov\u00e1 zl\u00fa\u010denina: v bunkov\u00fdch modeloch je prij\u00edman\u00fd nukleozidov\u00fdmi transport\u00e9rmi a fosforylovan\u00fd adenoz\u00ednkin\u00e1zou na zodpovedaj\u00faci ribonukleotid, v literat\u00fare ozna\u010dovan\u00fd ako ZMP. Tento nukleotid je \u0161truktur\u00e1lne pr\u00edbuzn\u00fd s AMP, a preto sa opisuje ako mimetikum AMP: in vitro sa via\u017ee na \u03b3-podjednotku AMPK a alostericky pos\u00fava enz\u00fdm do jeho akt\u00edvnej konform\u00e1cie bez toho, aby sa zmenil samotn\u00fd intracelul\u00e1rny pomer AMP\/ATP. T\u00e1to dvojstup\u0148ov\u00e1 premena rob\u00ed zl\u00fa\u010deninu zauj\u00edmavou pre enzymologick\u00fd a kin\u00e1zovo orientovan\u00fd laborat\u00f3rny v\u00fdskum. V d\u00f4sledku toho sa AICAR pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa AICAR vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>Enzymologick\u00fd v\u00fdskum alosterickej regul\u00e1cie AMP-aktivovanej prote\u00ednkin\u00e1zy a \u00falohy nukleotid via\u017eucej \u03b3-podjednotky in vitro.<\/li>\n<li>V\u00fdskum fosforyl\u00e1cie AICAR adenoz\u00ednkin\u00e1zou a tvorby a degrad\u00e1cie nukleotidu ZMP v bunkov\u00fdch modeloch.<\/li>\n<li>\u0160t\u00fadie de novo biosynt\u00e9zy pur\u00ednov, v ktorej je ribonukleotid AICAR prirodzen\u00fdm medziproduktom tejto dr\u00e1hy.<\/li>\n<li>Modelov\u00e9 \u0161t\u00fadie substr\u00e1tov fosforyl\u00e1cie AMPK v smere toku, ako je acetyl-CoA karboxyl\u00e1za, ktor\u00e1 sl\u00fa\u017ei ako parameter od\u010d\u00edtania kin\u00e1zovej aktivity v syst\u00e9moch bunkov\u00fdch kult\u00far.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm AICAR ako referen\u010dn\u00e9ho \u0161tandardu pre nukleozidov\u00e9 anal\u00f3gy.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti lyofilizovan\u00fdch nukleozidov\u00fdch anal\u00f3gov za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>AICAR v r\u00e1mci n\u00e1\u0161ho v\u00fdskumn\u00e9ho rozsahu<\/h2>\n<p>V r\u00e1mci n\u00e1\u0161ho produktov\u00e9ho radu patr\u00ed AICAR do kateg\u00f3rie lyofilizovan\u00fdch sk\u00faman\u00fdch zl\u00fa\u010den\u00edn vo forme liekoviek. V\u00fdskumn\u00edci pracuj\u00faci s touto kateg\u00f3riou \u010dasto kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi lyofilizovan\u00fdmi l\u00e1tkami, ktor\u00e9 sa \u0161tuduj\u00fa prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do sa AICAR zameriava na syst\u00e9m kin\u00e1zy riadenej nukleotidmi, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 tak, aby pokr\u00fdvali ciele viazan\u00e9 na receptory alebo sprostredkovan\u00e9 peptidmi. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia molekul\u00e1rnou triedou a sk\u00faman\u00fdm mechanizmom.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>AICAR<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Akadez\u00edn; AICA ribozid; 5-amino-1-\u03b2-D-ribofuranozylimidazol-4-karboxamid; GP-1-110; NSC-105823<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>2627-69-2<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>9<\/sub>H<sub>14<\/sub>N<sub>4<\/sub>O<sub>5<\/sub> \/ 258,23 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>17513<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Mal\u00e1 molekula, nukleozidov\u00fd anal\u00f3g (nepeptid)<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok v injek\u010dnej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1\u0148te pred svetlom a vlhkos\u0165ou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>AICAR sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok so \u0161tandardizovan\u00fdm mno\u017estvom 50 mg na injek\u010dn\u00fa liekovku, uzavret\u00fd gumovou z\u00e1tkou s hlin\u00edkov\u00fdm uz\u00e1verom. Na rozdiel od pevnej tablety sa tento lyofiliz\u00e1t rozp\u00fa\u0161\u0165a vo vhodnom rozp\u00fa\u0161\u0165adle v laborat\u00f3rnom prostred\u00ed pred analytickou alebo mechanickou pr\u00e1cou; lyofilizovan\u00fd stav sl\u00fa\u017ei predov\u0161etk\u00fdm na zabezpe\u010denie stability po\u010das skladovania a prepravy.<\/p>\n<p>Injek\u010dn\u00fa liekovku skladujte v chladni\u010dke, chr\u00e1nen\u00fa pred priamym svetlom a vlhkos\u0165ou, v p\u00f4vodnom obale. So zl\u00fa\u010deninou manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Pre t\u00fato zl\u00fa\u010deninu sa udr\u017eiava kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC), ako je obvykl\u00e9 pre lyofilizovan\u00e9 zl\u00fa\u010deniny vo forme liekovky. Liekovka obsahuje jeden lyofiliz\u00e1t bez pridan\u00fdch pomocn\u00fdch l\u00e1tok.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed AICAR?<\/strong><br \/>AICAR je mal\u00e1 syntetick\u00e1 molekula z triedy nukleozidov\u00fdch anal\u00f3gov, zlo\u017een\u00e1 z imidazol-4-karboxamidov\u00e9ho jadra a rib\u00f3zovej jednotky. Nie je to peptid, a preto neobsahuje \u017eiadnu aminokyselinov\u00fa sekvenciu.<\/p>\n<p><strong>Ak\u00e1 je \u00faloha ZMP vo v\u00fdskume?<\/strong><br \/>V bunkov\u00fdch modeloch je AICAR fosforylovan\u00fd adenoz\u00ednkin\u00e1zou na ribonukleotid ZMP. Tento nukleotid je \u0161truktur\u00e1lne podobn\u00fd AMP, a preto sa pova\u017euje za mimetikum AMP; je \u00fastredn\u00fdm bodom mechanistick\u00e9ho v\u00fdskumu alosterickej aktiv\u00e1cie AMPK in vitro.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg v uzavretej liekovke, ur\u010den\u00fd na rozpustenie vo vhodnom rozp\u00fa\u0161\u0165adle pred analytick\u00fdm pou\u017eit\u00edm.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chladni\u010dke, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou, najlep\u0161ie neotvoren\u00e9 v p\u00f4vodnom obale a bez opakovan\u00fdch zmien teploty.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"740\" data-end=\"802\">AICAR \u2013 Molekul\u00e1rna zl\u00fa\u010denina pre v\u00fdskumn\u00e9 aplik\u00e1cie<\/strong><br data-start=\"802\" data-end=\"805\" \/>AICAR (5-aminoimidazol-4-karboxamid ribonukleotid) je syntetick\u00e1 zl\u00fa\u010denina pou\u017e\u00edvan\u00e1 v laborat\u00f3rnych a predklinick\u00fdch v\u00fdskumn\u00fdch prostrediach. Molekula sa pou\u017e\u00edva na \u0161t\u00fadium chemick\u00fdch vlastnost\u00ed, molekul\u00e1rnej stability a interakci\u00ed s intracelul\u00e1rnymi procesmi za kontrolovan\u00fdch podmienok. AICAR nie je spotrebite\u013esk\u00fd produkt a nie je ur\u010den\u00fd na lek\u00e1rske ani fyziologick\u00e9 aplik\u00e1cie.<\/p>","protected":false},"featured_media":3268,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2862","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2862"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2862\/revisions"}],"predecessor-version":[{"id":2936,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2862\/revisions\/2936"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3268"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2862"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2862"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2862"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}