{"id":2855,"date":"2026-09-01T09:31:51","date_gmt":"2026-09-01T09:31:51","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2855"},"modified":"2026-09-02T12:15:07","modified_gmt":"2026-09-02T12:15:07","slug":"ss-31-vial-50-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/ss-31-vial-50-mg\/","title":{"rendered":"SS-31 injek\u010dn\u00e1 liekovka 50 mg"},"content":{"rendered":"<p>SS-31 je syntetick\u00fd peptid z triedy mitochondri\u00e1lne cielen\u00fdch, aromatick\u00fdch-kati\u00f3nov\u00fdch tetrapeptidov, chemicky tetrapeptidov\u00fd amid so striedav\u00fdm aromatick\u00fdm-kati\u00f3nov\u00fdm mot\u00edvom. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre biofyziku mitochondri\u00e1lnych membr\u00e1n a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je SS-31?<\/h2>\n<p>SS-31 (Elamipretid, v\u00fdvojov\u00fd k\u00f3d MTP-131) je mal\u00fd syntetick\u00fd peptid so sekvenciou D-Arg-Dmt-Lys-Phe-NH.<sub>2<\/sub>, kde Dmt znamen\u00e1 2\u2032,6\u2032-dimetyltyroz\u00edn a C-koniec je zachovan\u00fd v amidovej skupine. \u0160tyri zvy\u0161ky sa striedaj\u00fa v charaktere: dva z\u00e1sadit\u00e9, kladne nabit\u00e9 zvy\u0161ky (D-argin\u00edn a lyz\u00edn) s\u00fa oproti dvom aromatick\u00fdm zvy\u0161kom. Tento striedav\u00fd aromaticko-kati\u00f3nov\u00fd vzor d\u00e1va molekule \u010dist\u00fd kladn\u00fd n\u00e1boj pri fyziologickom pH v kombin\u00e1cii s v\u00fdrazn\u00fdmi hydrof\u00f3bnymi povrchmi a pr\u00e1ve tento dvojit\u00fd podpis rob\u00ed z SS-31 \u0161iroko pou\u017e\u00edvan\u00fa modelov\u00fa molekulu pri \u0161t\u00fadiu interakci\u00ed peptid-membr\u00e1na.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa SS-31 prim\u00e1rne sk\u00fama pre svoju selekt\u00edvnu afinitu ku kardiolip\u00ednu, ani\u00f3nov\u00e9mu fosfolipidu, ktor\u00fd sa nach\u00e1dza takmer v\u00fdlu\u010dne vo vn\u00fatornej mitochondri\u00e1lnej membr\u00e1ne. T\u00e1to v\u00e4zba sa opiera o dve s\u00fa\u010dasne p\u00f4sobiace sily: elektrostatick\u00fa pr\u00ed\u0165a\u017elivos\u0165 medzi kati\u00f3nov\u00fdmi zvy\u0161kami a negat\u00edvne nabit\u00fdmi hlavn\u00fdmi skupinami kardiolip\u00ednu a hydrof\u00f3bnu inzerciu aromatick\u00fdch bo\u010dn\u00fdch re\u0165azcov do lipidovej vrstvy. In vitro bolo op\u00edsan\u00e9, \u017ee t\u00e1to interakcia ovplyv\u0148uje membr\u00e1nov\u00e9 balenie a n\u00e1sledne organiz\u00e1ciu prote\u00ednov\u00fdch komplexov ukotven\u00fdch v nej, vr\u00e1tane superkomplexov d\u00fdchacieho re\u0165azca. V d\u00f4sledku toho sa SS-31 pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa SS-31 vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>Biofyzik\u00e1lny v\u00fdskum v\u00e4zby kati\u00f3nov\u00fdch peptidov na kardiolip\u00edn v lipoz\u00f3moch a modeloch umel\u00fdch membr\u00e1n.<\/li>\n<li>Modelov\u00e9 \u0161t\u00fadie stability superkomplexov mitochondri\u00e1lneho respira\u010dn\u00e9ho re\u0165azca v izolovan\u00fdch mitochondri\u00e1ch.<\/li>\n<li>Enzymologick\u00e9 sk\u00famanie peroxid\u00e1zovej aktivity kardiolip\u00edn-cytochr\u00f3mov\u00e9ho c komplexu in vitro.<\/li>\n<li>\u0160t\u00fadia \u0161trukt\u00fary a aktivity, v ktorej sa striedaj\u00faci sa aromatick\u00fd-kati\u00f3nov\u00fd mot\u00edv porovn\u00e1va s modifikovan\u00fdmi anal\u00f3gmi.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm SS-31 ako referen\u010dn\u00e9ho \u0161tandardu pre tetrapeptidy.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti lyofilizovan\u00fdch peptidov s D-aminokyselinami za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>SS-31 v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>SS-31 patr\u00ed do kateg\u00f3rie lyofilizovan\u00fdch v\u00fdskumn\u00fdch peptidov vo forme liekoviek v r\u00e1mci n\u00e1\u0161ho sortimentu. V\u00fdskumn\u00edci pracuj\u00faci s touto kateg\u00f3riou \u010dasto kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi peptidmi, ktor\u00e9 maj\u00fa svoj vlastn\u00fd biochemick\u00fd cie\u013e. Zatia\u013e \u010do SS-31 sa zameriava na interakciu so \u0161pecifick\u00fdm membr\u00e1nov\u00fdm fosfolipidom, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 \u0161peci\u00e1lne na pokrytie cie\u013eov viazan\u00fdch na receptory alebo enzymatick\u00fdch cie\u013eov. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia v aminokyselinovej sekvencii a sk\u00famanom mechanizme.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>SS-31<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Elamipretid; MTP-131; D-Arg-Dmt-Lys-Phe-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>736992-21-5<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>32<\/sub>H<sub>49<\/sub>N<sub>9<\/sub>O<sub>5<\/sub> \/ 639,8 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>11764719<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd aromatick\u00fd-kati\u00f3nov\u00fd tetrapeptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ok)<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1\u0148te pred svetlom a vlhkos\u0165ou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>SS-31 sa dod\u00e1va ako lyofilizovan\u00fd biely a\u017e sivobiely pr\u00e1\u0161ok v uzavretej sklenenej liekovke obsahuj\u00facej \u0161tandardizovan\u00e9 mno\u017estvo 50 mg. Tento lyofiliz\u00e1t je ur\u010den\u00fd na rozpustenie vo vhodnom rozp\u00fa\u0161\u0165adle v laborat\u00f3rnom prostred\u00ed pred \u010fal\u0161ou anal\u00fdzou. Pr\u00e1\u0161ok je hygroskopick\u00fd a po vystaven\u00ed okolit\u00e9mu vzduchu absorbuje vlhkos\u0165.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte v chladni\u010dke, chr\u00e1nen\u00fa pred priamym svetlom a vlhkos\u0165ou, v p\u00f4vodnom obale. S pripojen\u00edm manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pred otvoren\u00edm nechajte liekovku dosiahnu\u0165 izbov\u00fa teplotu, aby sa minimalizovala kondenz\u00e1cia, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Pri tomto lyofiliz\u00e1te sa dodr\u017eiava kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC), pri\u010dom identita je potvrden\u00e1 prostredn\u00edctvom prilo\u017eenej analytickej dokument\u00e1cie.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed SS-31?<\/strong><br \/>SS-31 je syntetick\u00fd tetrapeptid so striedav\u00fdm aromaticko-kati\u00f3nov\u00fdm mot\u00edvom a C-termin\u00e1lnym amidom s definovanou aminokyselinovou sekvenciou \u0161tyroch zvy\u0161kov.<\/p>\n<p><strong>Ak\u00e1 je \u00faloha kardiolip\u00ednu v tejto \u0161t\u00fadii?<\/strong><br \/>Kardiolip\u00edn je ani\u00f3nov\u00fd fosfolipid, na ktor\u00fd sa SS-31 selekt\u00edvne via\u017ee in vitro. T\u00e1to v\u00e4zba je \u00fastredn\u00fdm zameran\u00edm mechanistick\u00e9ho laborat\u00f3rneho v\u00fdskumu organiz\u00e1cie membr\u00e1novo viazan\u00fdch prote\u00ednov\u00fdch komplexov v modelov\u00fdch syst\u00e9moch.<\/p>\n<p><strong>Pre\u010do sekvencia obsahuje D-argin\u00edn a metylovan\u00fd tyroz\u00edn?<\/strong><br \/>Obe modifik\u00e1cie robia peptid menej n\u00e1chyln\u00fdm na enzymatick\u00fa degrad\u00e1ciu in vitro a ovplyv\u0148uj\u00fa rozlo\u017eenie n\u00e1boja v molekule. V\u010faka tomu sl\u00fa\u017ei zl\u00fa\u010denina ako stabiln\u00fd referen\u010dn\u00fd bod v \u0161t\u00fadi\u00e1ch \u0161trukt\u00fary a aktivity.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 lyofilizovan\u00fd pr\u00e1\u0161ok?<\/strong><br \/>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou, najlep\u0161ie v p\u00f4vodne uzavretej liekovke. Zabr\u00e1\u0148te opakovan\u00fdm zmen\u00e1m teploty a kondenz\u00e1cii.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong>SS-31<\/strong>, tie\u017e zn\u00e1my ako <strong>Elamipretid<\/strong>SS-31 je syntetick\u00fd tetrapeptid s unik\u00e1tnou aromaticko-kati\u00f3novou \u0161trukt\u00farou, ktor\u00e1 sa selekt\u00edvne akumuluje vo vn\u00fatornej mitochondri\u00e1lnej membr\u00e1ne. Vo v\u00fdskume sa sk\u00fama v\u00e4zba SS-31 na kardiolip\u00edn a jeho \u00faloha v modeloch mitochondri\u00e1lnej dysfunkcie.<\/p>","protected":false},"featured_media":3233,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2855","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2855"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2855\/revisions"}],"predecessor-version":[{"id":2928,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2855\/revisions\/2928"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3233"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2855"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2855"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2855"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}