{"id":2847,"date":"2026-09-01T09:31:28","date_gmt":"2026-09-01T09:31:28","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2847"},"modified":"2026-09-02T12:15:14","modified_gmt":"2026-09-02T12:15:14","slug":"5-amino-1mq-vial-50-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/5-amino-1mq-vial-50-mg\/","title":{"rendered":"5-Amino-1MQ injek\u010dn\u00e1 liekovka 50 mg"},"content":{"rendered":"<p>5-Amino-1MQ je syntetick\u00e1 mal\u00e1 molekula z triedy kvart\u00e9rnych chinol\u00ednov\u00fdch sol\u00ed, chemicky 5-aminosubstituovan\u00fd 1-metylchinol\u00ednium. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre enzymol\u00f3giu metyltransfer\u00e1zy a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je 5-Amino-1MQ?<\/h2>\n<p>5-Amino-1MQ (1-metylchinol\u00edn-1-ium-5-am\u00edn, dod\u00e1van\u00fd ako jodidov\u00e1 so\u013e) je mal\u00e1 organick\u00e1 molekula obklopuj\u00faca bicyklick\u00fd chinol\u00ednov\u00fd skelet. At\u00f3m dus\u00edka v kruhu nesie metylov\u00fa skupinu, \u010do d\u00e1va molekule permanentne kladne nabit\u00e9 kvart\u00e9rne chinol\u00edniov\u00e9 jadro; aminoskupina sa nach\u00e1dza v polohe 5. Tento fixn\u00fd n\u00e1boj ur\u010duje jej spr\u00e1vanie v laborat\u00f3riu: na rozdiel od ionizovate\u013en\u00e9ho am\u00ednu sa n\u00e1boj nemen\u00ed s pH, v\u010faka \u010domu sa s molekulou \u013eahko manipuluje v kati\u00f3novej v\u00fdmennej chromatografii. Okrem toho, elektr\u00f3nmi bohat\u00fd aminosubstituent pos\u00fava absorp\u010dn\u00fd p\u00e1s konjugovan\u00e9ho kruhov\u00e9ho syst\u00e9mu a poskytuje zrete\u013en\u00fd chromof\u00f3r v UV oblasti. V\u010faka tomu je t\u00e1to zl\u00fa\u010denina \u0161iroko pou\u017e\u00edvanou modelovou molekulou pri \u0161t\u00fadiu metyla\u010dn\u00fdch reakci\u00ed z\u00e1visl\u00fdch od S-adenozylmetion\u00ednu.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa 5-Amino-1MQ pou\u017e\u00edva na \u0161t\u00fadium enz\u00fdmu nikot\u00ednamid-N-metyltransfer\u00e1za (NNMT). NNMT pren\u00e1\u0161a metylov\u00fa skupinu z kofaktora S-adenozylmetion\u00ednu (SAM) na nikot\u00ednamid, \u010do vedie k tvorbe 1-metylnikot\u00ednamidu a S-adenozylhomocyste\u00ednu. In vitro sa 5-Amino-1MQ via\u017ee na substr\u00e1tov\u00e9 vrecko tohto enz\u00fdmu, a preto je v literat\u00fare op\u00edsan\u00fd ako inhib\u00edtor tohto metyla\u010dn\u00e9ho kroku; nabit\u00fd chinol\u00edniov\u00fd mot\u00edv napodob\u0148uje metylovan\u00fa pyrid\u00edniov\u00fa \u0161trukt\u00faru reak\u010dn\u00e9ho produktu. N\u00e1sledne sa sk\u00famaj\u00fa d\u00f4sledky pre nikot\u00ednamid a NAD v bunkov\u00fdch modeloch.<sup>+<\/sup>-recykla\u010dn\u00e1 cesta a pre z\u00e1sobu metylov\u00fdch donorov. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa preto 5-amino-1MQ pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa 5-Amino-1MQ vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>Enzymologick\u00e9 sk\u00famanie nikot\u00ednamid-N-metyltransfer\u00e1zy (NNMT) a kinetiky SAM-dependentn\u00e9ho prenosu metylu in vitro.<\/li>\n<li>Modelov\u00e9 \u0161t\u00fadie nikot\u00ednamidu a NAD<sup>+<\/sup>-recykla\u010dn\u00e1 dr\u00e1ha v bunkov\u00fdch modeloch a bezbunkov\u00fdch enz\u00fdmov\u00fdch syst\u00e9moch.<\/li>\n<li>\u0160t\u00fadia vz\u0165ahu \u0161trukt\u00fary a aktivity anal\u00f3gov chinol\u00ednia a izochinol\u00ednia ako inhib\u00edtorov metyltransfer\u00e1zy.<\/li>\n<li>Biofyzik\u00e1lne v\u00e4zbov\u00e9 \u0161t\u00fadie interakcie medzi nabit\u00fdm chinol\u00ednov\u00fdm mot\u00edvom a substr\u00e1tov\u00fdm vreckom.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC s UV detekciou, LC-MS) s 5-Amino-1MQ ako referen\u010dn\u00fdm \u0161tandardom.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti kvart\u00e9rnych am\u00f3niov\u00fdch sol\u00ed za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>5-Amino-1MQ v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>5-Amino-1MQ patr\u00ed do n\u00e1\u0161ho sortimentu v r\u00e1mci lyofilizovan\u00fdch sk\u00faman\u00fdch zl\u00fa\u010den\u00edn vo forme liekoviek, \u010do je kateg\u00f3ria, ktor\u00fa v\u00fdskumn\u00edci pravidelne kombinuj\u00fa s l\u00e1tkami \u0161tudovan\u00fdmi prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do 5-Amino-1MQ sa zameriava na metyltransfer\u00e1zu a s \u0148ou spojen\u00fa homeost\u00e1zu kofaktorov, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli \u0161peci\u00e1lne vybran\u00e9 na pokrytie cie\u013eov viazan\u00fdch na receptory, koordinovan\u00fdch kovmi alebo peptidmi. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia molekul\u00e1rnou triedou a sk\u00faman\u00fdm mechanizmom.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>5-Amino-1MQ (5-amino-1-metylchinol\u00edniumjodid)<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>1-metylchinol\u00edn-1-ium-5-am\u00edn jodid; chinol\u00ednium, 5-amino-1-metyl-, jodid (1:1); NNMTi<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>42464-96-0<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>10<\/sub>H<sub>11<\/sub>VN\u00daTRI<sub>2<\/sub> \/ 286,11 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>66522933<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Mal\u00e1 molekula, kvart\u00e9rna chinol\u00edniov\u00e1 so\u013e; inhib\u00edtor nikot\u00ednamid-N-metyltransfer\u00e1zy<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofilizovan\u00fd pr\u00e1\u0161ok) v uzavretej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Skladujte na chladnom a tmavom mieste, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>5-Amino-1MQ sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg na injek\u010dn\u00fa liekovku, uzavret\u00fd gumovou z\u00e1tkou s hlin\u00edkov\u00fdm tesnen\u00edm. Je to kvart\u00e9rna am\u00f3niov\u00e1 so\u013e v pevnej forme; materi\u00e1l sa odv\u00e1\u017ei v laborat\u00f3rnom zariaden\u00ed a \u010falej sa spracuje pod\u013ea pr\u00edslu\u0161n\u00e9ho analytick\u00e9ho alebo enzymologick\u00e9ho protokolu. Hygroskopick\u00e9 spr\u00e1vanie je pre t\u00fato triedu l\u00e1tok zn\u00e1mym bodom pozornosti.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte na chladnom a tmavom mieste, chr\u00e1nenom pred svetlom a vlhkos\u0165ou, najlep\u0161ie v p\u00f4vodnom obale. Jodidov\u00e9 soli s\u00fa citliv\u00e9 na dlhodob\u00e9 vystavenie svetlu, ktor\u00e9 m\u00f4\u017ee sp\u00f4sobi\u0165 zmenu farby pr\u00e1\u0161ku. So zl\u00fa\u010deninou manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Lyofiliz\u00e1t obsahuje 50 mg 5-Amino-1MQ na injek\u010dn\u00fa liekovku s kontrolovanou \u010distotou \u2265 99 % (HPLC). Nie s\u00fa pridan\u00e9 \u017eiadne stabiliz\u00e1tory ani plniv\u00e1, tak\u017ee zl\u00fa\u010denina zost\u00e1va pou\u017eite\u013en\u00e1 ako referen\u010dn\u00fd materi\u00e1l v analytick\u00fdch pr\u00e1cach.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>, kde sa spr\u00e1vy centr\u00e1lne zhroma\u017e\u010fuj\u00fa pre va\u0161e vlastn\u00e9 v\u00fdskumn\u00e9 z\u00e1znamy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed 5-Amino-1MQ?<\/strong><br \/>Mal\u00e1 syntetick\u00e1 molekula: kvart\u00e9rna chinol\u00edniov\u00e1 so\u013e s aminoskupinou v polohe 5, dod\u00e1van\u00e1 ako jodidov\u00e1 so\u013e. \u200b\u200bNie je to peptid, a preto neobsahuje \u017eiadnu aminokyselinov\u00fa sekvenciu.<\/p>\n<p><strong>Ktor\u00fd enz\u00fdm je \u00fastredn\u00fdm prvkom sk\u00faman\u00e9ho mechanizmu?<\/strong><br \/>Nikot\u00ednamid-N-metyltransfer\u00e1za (NNMT). In vitro tento enz\u00fdm pren\u00e1\u0161a metylov\u00fa skupinu z S-adenozylmetion\u00ednu na nikot\u00ednamid; 5-Amino-1MQ je v literat\u00fare op\u00edsan\u00fd ako inhib\u00edtor tohto kroku.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 50 mg v uzavretej injek\u010dnej liekovke, bez pridan\u00fdch pomocn\u00fdch l\u00e1tok.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chlade a tme, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou, najlep\u0161ie neotvoren\u00e9 v p\u00f4vodnom obale.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong data-start=\"825\" data-end=\"885\">5-amino-1MQ \u2013 mal\u00e1 molekula pre v\u00fdskumn\u00e9 aplik\u00e1cie<\/strong><br data-start=\"885\" data-end=\"888\" \/>5-amino-1MQ (5-amino-1-metylchinol\u00ednium) je syntetick\u00e1 mal\u00e1 molekula pou\u017e\u00edvan\u00e1 v laborat\u00f3rnych a predklinick\u00fdch v\u00fdskumn\u00fdch prostrediach. Molekula sa pou\u017e\u00edva na \u0161t\u00fadie sk\u00famaj\u00face chemick\u00fa stabilitu, molekul\u00e1rne interakcie a experiment\u00e1lne sign\u00e1lne dr\u00e1hy. 5-amino-1MQ nie je spotrebite\u013esk\u00fd produkt a nie je ur\u010den\u00fd na fyziologick\u00e9, lek\u00e1rske ani nutri\u010dn\u00e9 \u200b\u200b\u200b\u200baplik\u00e1cie.<\/p>","protected":false},"featured_media":3238,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2847","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2847"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2847\/revisions"}],"predecessor-version":[{"id":2924,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2847\/revisions\/2924"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3238"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2847"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2847"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2847"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}