{"id":2819,"date":"2026-09-01T09:29:42","date_gmt":"2026-09-01T09:29:42","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2819"},"modified":"2026-09-02T12:24:37","modified_gmt":"2026-09-02T12:24:37","slug":"selank","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/selank\/","title":{"rendered":"Selank"},"content":{"rendered":"<h2>\u010co je Selank?<\/h2>\n<p>Selank je syntetick\u00fd line\u00e1rny heptapeptid s aminokyselinovou sekvenciou Thr-Lys-Pro-Arg-Pro-Gly-Pro. Re\u0165azec pozost\u00e1va z prirodzene sa vyskytuj\u00faceho tetrapeptidov\u00e9ho mot\u00edvu (Thr-Lys-Pro-Arg), ku ktor\u00e9mu je na C-konci pripojen\u00fd tripeptid Pro-Gly-Pro. Zl\u00fa\u010denina m\u00e1 \u010d\u00edslo CAS 129954-34-3 a molekulov\u00fd vzorec C.<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> a molekulov\u00fa hmotnos\u0165 pribli\u017ene 751,9 Da (PubChem CID 11765600).<\/p>\n<p>S tromi prol\u00ednov\u00fdmi zvy\u0161kami na siedmich poz\u00edci\u00e1ch je Selank sekvencia v\u00fdrazne bohat\u00e1 na prol\u00edn. Prol\u00edn obmedzuje rota\u010dn\u00fa slobodu hlavn\u00e9ho re\u0165azca a sekvencia prol\u00edn-glyc\u00edn-prol\u00edn na C-termin\u00e1lnom konci zvy\u0161uje rigiditu tohto konca, \u010d\u00edm obmedzuje \u00fatok exopeptid\u00e1zami; v laborat\u00f3rnych podmienkach je v\u010faka tomu re\u0165azec merate\u013ene stabilnej\u0161\u00ed ako neroztiahnut\u00fd tetrapeptidov\u00fd mot\u00edv, ktor\u00fd sa v definovan\u00fdch pufrovac\u00edch syst\u00e9moch r\u00fdchlo degraduje. Okrem toho dva silne z\u00e1sadit\u00e9 zvy\u0161ky \u2013 lyz\u00edn a argin\u00edn \u2013 d\u00e1vaj\u00fa molekule vysok\u00fd izoelektrick\u00fd bod a v\u00fdrazne hydrofiln\u00fd charakter, zatia\u013e \u010do re\u0165azec neobsahuje \u017eiadne aromatick\u00e9 zvy\u0161ky. V d\u00f4sledku toho sa detekcia nespolieha na absorpciu pri 280 nm, ale na samotn\u00fa peptidov\u00fa v\u00e4zbu okolo 210 \u2013 220 nm. T\u00e1to kombin\u00e1cia rigidity re\u0165azca, vysokej hydrofilnosti a absencie chromof\u00f3ru rob\u00ed zo Selanku in\u0161trukt\u00e1\u017enu modelov\u00fa zl\u00fa\u010deninu v porovn\u00e1vacom v\u00fdskume peptidov a pri v\u00fdvoji analytick\u00fdch met\u00f3d.<\/p>\n<h2>Aplik\u00e1cie v laborat\u00f3rnom kontexte<\/h2>\n<p>V r\u00e1mci peptidovej ch\u00e9mie a analytickej pr\u00e1ce sa Selank okrem in\u00e9ho venuje nasleduj\u00facim oblastiam v\u00fdskumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdskum vz\u0165ahu \u0161trukt\u00fary a aktivity<\/strong> pr\u00edspevku Pro-Gly-Pro konca, kde je pred\u013a\u017een\u00e1 sekvencia pozd\u013a\u017e nepred\u013a\u017een\u00e9ho tetrapeptidov\u00e9ho mot\u00edvu charakterizovan\u00e1 rigiditou re\u0165azca, profilom n\u00e1boja a chromatografick\u00fdm spr\u00e1van\u00edm.<\/li>\n<li><strong>V\u00fdskum peptidovej ch\u00e9mie<\/strong> t\u00fdkaj\u00face sa spr\u00e1vania kr\u00e1tkych, na prol\u00edn bohat\u00fdch a vysoko hydrofiln\u00fdch re\u0165azcov: rozpustnos\u0165, retencia v chromatografii s reverznou f\u00e1zou pri n\u00edzkom organickom podiele a cis-trans izom\u00e9ria okolo prol\u00ednovej peptidovej v\u00e4zby ako zdroj roz\u0161\u00edrenia p\u00edku.<\/li>\n<li><strong>\u0160t\u00fadie enzymatickej stability<\/strong> v ktorom sa r\u00fdchlos\u0165 degrad\u00e1cie amino- a karboxypeptid\u00e1zami monitoruje v definovan\u00fdch pufrovac\u00edch syst\u00e9moch a v\u00fdsledn\u00e9 fragmenty sa prira\u010fuj\u00fa hmotnostnou spektrometriou.<\/li>\n<li><strong>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d<\/strong> (HPLC, LC-MS, mapovanie peptidov), kde Selank sl\u00fa\u017ei ako referen\u010dn\u00fd \u0161tandard pre sekvencie bez aromatick\u00e9ho chromof\u00f3ru, s detekciou amidovej v\u00e4zby v \u010falekom UV spektre a s potvrden\u00edm identity hmotnostnou spektrometriou.<\/li>\n<\/ul>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Vzorka<\/strong><\/td>\n<td>Selank<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u013a\u017eka peptidu<\/strong><\/td>\n<td>7 aminokyselinov\u00fdch zvy\u0161kov<\/td>\n<\/tr>\n<tr>\n<td><strong>Postupnos\u0165<\/strong><\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>129954-34-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/strong><\/td>\n<td>C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \/ pribli\u017ene 751,9 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>Trieda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rny heptapeptid bohat\u00fd na prol\u00edn s C-termin\u00e1lnym Pro-Gly-Pro mot\u00edvom<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1r<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofilizovan\u00fd pr\u00e1\u0161ok) v uzavretej sklenenej liekovke<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladovanie<\/strong><\/td>\n<td>Lyofilizovan\u00e9 pri teplote 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Materi\u00e1l sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v uzavretej sklenenej liekovke so septom a zmr\u0161\u0165ovac\u00edm uz\u00e1verom. Lyofiliz\u00e1t je biely a\u017e sivobiely a m\u00e1 formu kompaktn\u00e9ho kol\u00e1\u010da alebo jemn\u00e9ho pr\u00e1\u0161ku; oboje s\u00fa be\u017en\u00e9 prejavy procesu lyofiliz\u00e1cie. Materi\u00e1l je hygroskopick\u00fd \u2013 o to viac v silne hydrofilnom, z\u00e1saditom zlo\u017een\u00ed \u2013 a preto zost\u00e1va uzavret\u00fd v p\u00f4vodnom obale a\u017e do spracovania v laborat\u00f3riu.<\/p>\n<p>Neotvoren\u00fd lyofilizovan\u00fd lyofilizovan\u00fd pr\u00e1\u0161ok skladujte v chladni\u010dke pri teplote 2 \u2013 8 \u00b0C, na suchom a tmavom mieste, chr\u00e1nenom pred svetlom a vlhkos\u0165ou; pri dlh\u0161om skladovan\u00ed sa zvy\u010dajne skladuje zmrazen\u00fd. Pred otvoren\u00edm nechajte injek\u010dn\u00fa liekovku dosiahnu\u0165 izbov\u00fa teplotu, aby sa minimalizovala kondenz\u00e1cia, pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi laborat\u00f3rnymi materi\u00e1lmi. Zvy\u0161n\u00fd materi\u00e1l zlikvidujte v s\u00falade s platn\u00fdmi laborat\u00f3rnymi pokynmi.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>Pre kr\u00e1tke re\u0165azce bohat\u00e9 na prol\u00edn s\u00fa ur\u010duj\u00facimi parametrami identita a \u010distota: skr\u00e1ten\u00e9 re\u0165azce a del\u00e9\u010dn\u00e9 varianty sa l\u00ed\u0161ia len mierne v retencii a absencia aromatick\u00e9ho chromof\u00f3ru kladie \u010fal\u0161ie n\u00e1roky na detekciu. N\u00e1\u0161 Selank sa dod\u00e1va s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v s\u00falade s pr\u00edslu\u0161n\u00fdm analytick\u00fdm certifik\u00e1tom. Dostupn\u00e9 analytick\u00e9 certifik\u00e1ty si m\u00f4\u017eete pozrie\u0165 na na\u0161ej webovej str\u00e1nke. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>D\u00f4le\u017eit\u00e9 vyhl\u00e1senie o vyl\u00fa\u010den\u00ed zodpovednosti<\/h2>\n<p>Tento produkt dod\u00e1vame v\u00fdhradne na laborat\u00f3rny v\u00fdskum a analytick\u00e9 pr\u00e1ce. Nie je ur\u010den\u00fd na diagnostick\u00e9 ani terapeutick\u00e9 aplik\u00e1cie a v\u00fdslovne nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed alebo zvierat. Tento produkt nie je potravinou, doplnkom stravy, kozmetick\u00fdm v\u00fdrobkom ani registrovan\u00fdm liekom. K\u00fapou tohto produktu kupuj\u00faci potvrdzuje, \u017ee m\u00e1 18 rokov alebo viac a bude ho pou\u017e\u00edva\u0165 v\u00fdlu\u010dne v kontrolovanom v\u00fdskumnom alebo laborat\u00f3rnom prostred\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>Selank je syntetick\u00fd line\u00e1rny heptapeptid (C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub>, pribli\u017ene 751,9 g\/mol) s tromi prol\u00ednov\u00fdmi zvy\u0161kami a C-termin\u00e1lnym Pro-Gly-Pro mot\u00edvom, ktor\u00fd spev\u0148uje koniec re\u0165azca. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina v peptidovej ch\u00e9mii a analytick\u00fdch pr\u00e1cach. Ur\u010den\u00e9 v\u00fdlu\u010dne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie na pou\u017eitie u \u013eud\u00ed alebo zvierat. Nie je to liek.<\/p>","protected":false},"featured_media":3232,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,121],"product_tag":[],"class_list":["post-2819","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2819"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2819\/revisions"}],"predecessor-version":[{"id":2893,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2819\/revisions\/2893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3232"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2819"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2819"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2819"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}