{"id":2804,"date":"2026-09-01T09:28:00","date_gmt":"2026-09-01T09:28:00","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2804"},"modified":"2026-09-02T12:18:33","modified_gmt":"2026-09-02T12:18:33","slug":"vip-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/vip-10mg\/","title":{"rendered":"VIP 10 mg"},"content":{"rendered":"<h2>\u010co je VIP?<\/h2>\n<p>VIP je syntetick\u00fd line\u00e1rny polypeptid zlo\u017een\u00fd z dvadsiatich \u00f4smich aminokyselinov\u00fdch zvy\u0161kov so sekvenciou His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn. Zl\u00fa\u010denina m\u00e1 \u010d\u00edslo CAS 37221-79-7 a molekulov\u00fd vzorec C.<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S a molekulovou hmotnos\u0165ou pribli\u017ene 3326,8 Da (PubChem CID 53314964).<\/p>\n<p>Re\u0165azec kombinuje kysl\u00fd N-termin\u00e1lny segment s dvoma aspart\u00e1tov\u00fdmi zvy\u0161kami a v\u00fdrazne z\u00e1sadit\u00fa stredn\u00fa \u010das\u0165 obsahuj\u00facu dva argin\u00ednov\u00e9 a tri lyz\u00ednov\u00e9 zvy\u0161ky; v celej sekvencii to vedie k \u010distej z\u00e1saditosti a vysok\u00e9mu izoelektrick\u00e9mu bodu. Jeden metion\u00ednov\u00fd zvy\u0161ok tvor\u00ed jedin\u00fd bod obsahuj\u00faci s\u00edru, a preto citliv\u00fd na oxid\u00e1ciu, zatia\u013e \u010do fenylalan\u00edn a dva tyroz\u00ednov\u00e9 zvy\u0161ky zabezpe\u010duj\u00fa UV absorpciu. V roztoku molekula zauj\u00edma \u03b1-helixov\u00fa konform\u00e1ciu na ve\u013ekej \u010dasti re\u0165azca, pri\u010dom nepol\u00e1rne zvy\u0161ky sa zoskupuj\u00fa na jednej strane helixu: amfipatick\u00fd vzor, \u200b\u200bktor\u00fd \u010diasto\u010dne ur\u010duje jej spr\u00e1vanie na hydrof\u00f3bnych povrchoch a retenciu v chromatografii s reverznou f\u00e1zou. T\u00e1to kombin\u00e1cia d\u013a\u017eky re\u0165azca, distrib\u00facie n\u00e1boja a v\u00fdraznej tvorby helixu rob\u00ed z VIP \u0161iroko pou\u017e\u00edvan\u00fa modelov\u00fa zl\u00fa\u010deninu v konforma\u010dnom a \u0161truktur\u00e1lnom v\u00fdskume peptidov strednej d\u013a\u017eky.<\/p>\n<h2>Aplik\u00e1cie v laborat\u00f3rnom kontexte<\/h2>\n<p>V r\u00e1mci peptidovej ch\u00e9mie a analytick\u00fdch pr\u00e1c sa VIP vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdskum vz\u0165ahu \u0161trukt\u00fary a aktivity<\/strong> v ktor\u00fdch s\u00fa jednotliv\u00e9 zvy\u0161ky substituovan\u00e9, aby sa charakterizoval ich pr\u00edspevok k stabilite helixu, distrib\u00facii n\u00e1boja a amfipatii.<\/li>\n<li><strong>V\u00fdskum peptidovej ch\u00e9mie<\/strong> smerom k rozpustnosti, agreg\u00e1cii a tvorbe helixu amfipatick\u00fdch re\u0165azcov, stanoven\u00edm konform\u00e1cie pomocou cirkul\u00e1rneho dichroizmu a NMR spektroskopie vo vodnom a helix indukuj\u00facom m\u00e9diu, ako je triflu\u00f3retanol.<\/li>\n<li><strong>\u0160t\u00fadie enzymatickej stability<\/strong> v ktor\u00fdch sa degrad\u00e1cia endo- a exopeptid\u00e1zami monitoruje v definovan\u00fdch pufrovac\u00edch syst\u00e9moch; helik\u00e1lne segmenty a flexibiln\u00e9 konce sa jasne l\u00ed\u0161ia v ich dostupnosti pre enz\u00fdmy.<\/li>\n<li><strong>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d<\/strong> (HPLC, LC-MS, anal\u00fdza aminokysel\u00edn, mapovanie peptidov), kde VIP sl\u00fa\u017ei ako referen\u010dn\u00fd \u0161tandard pre dlh\u00e9 syntetick\u00e9 re\u0165azce, vr\u00e1tane priradenia dele\u010dn\u00fdch sekvenci\u00ed a oxida\u010dn\u00fdch produktov metion\u00ednov\u00e9ho zvy\u0161ku.<\/li>\n<\/ul>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Vzorka<\/strong><\/td>\n<td>VIP<\/td>\n<\/tr>\n<tr>\n<td><strong>D\u013a\u017eka peptidu<\/strong><\/td>\n<td>28 aminokyselinov\u00fdch zvy\u0161kov<\/td>\n<\/tr>\n<tr>\n<td><strong>Postupnos\u0165<\/strong><\/td>\n<td>His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>37221-79-7<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/strong><\/td>\n<td>C<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S \/ pribli\u017ene 3326,8 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>Trieda<\/strong><\/td>\n<td>Syntetick\u00fd line\u00e1rny polypeptid (28 zvy\u0161kov), v roztoku preva\u017ene \u03b1-helik\u00e1lny<\/td>\n<\/tr>\n<tr>\n<td><strong>Forma<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej liekovke, 10 mg<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010cistota<\/strong><\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladovanie<\/strong><\/td>\n<td>Lyofilizovan\u00e9 pri teplote 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Materi\u00e1l sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v uzavretej sklenenej liekovke so septom a zmr\u0161\u0165ovac\u00edm uz\u00e1verom v mno\u017estve 10 mg. Proces lyofiliz\u00e1cie zachov\u00e1va molekul\u00e1rnu integritu re\u0165azca po\u010das skladovania a prepravy. Lyofiliz\u00e1t je biely a\u017e sivobiely a m\u00e1 formu kompaktn\u00e9ho kol\u00e1\u010da alebo sypk\u00e9ho pr\u00e1\u0161ku; oboje je norm\u00e1lny vzh\u013ead. Materi\u00e1l je hygroskopick\u00fd a zost\u00e1va uzavret\u00fd v p\u00f4vodnom obale a\u017e do spracovania v laborat\u00f3riu.<\/p>\n<p>Neotvoren\u00fd lyofilizovan\u00fd lyofilizovan\u00fd pr\u00e1\u0161ok skladujte v chladni\u010dke pri teplote 2 \u2013 8 \u00b0C, na suchom a tmavom mieste, chr\u00e1nenom pred svetlom a vlhkos\u0165ou; pri dlh\u0161om skladovan\u00ed sa zvy\u010dajne skladuje zmrazen\u00fd. Pred otvoren\u00edm nechajte injek\u010dn\u00fa liekovku dosiahnu\u0165 izbov\u00fa teplotu, aby sa minimalizovala kondenz\u00e1cia, pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi laborat\u00f3rnymi materi\u00e1lmi. Zvy\u0161n\u00fd materi\u00e1l zlikvidujte v s\u00falade s platn\u00fdmi laborat\u00f3rnymi pokynmi.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>Pre re\u0165azec s dvadsiatimi \u00f4smimi zvy\u0161kami s\u00fa ur\u010duj\u00facimi parametrami identita a \u010distota: dele\u010dn\u00e9 sekvencie, ne\u00faplne \u0161tiepen\u00e9 ochrann\u00e9 \u010dinidl\u00e1 a oxid\u00e1cia metion\u00ednov\u00e9ho zvy\u0161ku s\u00fa chromatograficky bl\u00edzke cie\u013eovej zl\u00fa\u010denine a m\u00f4\u017eu ovplyvni\u0165 interpret\u00e1ciu v\u00fdsledkov merania. N\u00e1\u0161 VIP sa dod\u00e1va s \u010distotou \u2265 99 %, stanovenou HPLC anal\u00fdzou v s\u00falade s pr\u00edslu\u0161n\u00fdm certifik\u00e1tom anal\u00fdzy. Dostupn\u00e9 certifik\u00e1ty anal\u00fdzy si m\u00f4\u017eete pozrie\u0165 na na\u0161ej webovej str\u00e1nke. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>D\u00f4le\u017eit\u00e9 vyhl\u00e1senie o vyl\u00fa\u010den\u00ed zodpovednosti<\/h2>\n<p>Tento produkt dod\u00e1vame v\u00fdhradne na laborat\u00f3rny v\u00fdskum a analytick\u00e9 pr\u00e1ce. Nie je ur\u010den\u00fd na diagnostick\u00e9 ani terapeutick\u00e9 aplik\u00e1cie a v\u00fdslovne nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed alebo zvierat. Tento produkt nie je potravinou, doplnkom stravy, kozmetick\u00fdm v\u00fdrobkom ani registrovan\u00fdm liekom. K\u00fapou tohto produktu kupuj\u00faci potvrdzuje, \u017ee m\u00e1 18 rokov alebo viac a bude ho pou\u017e\u00edva\u0165 v\u00fdlu\u010dne v kontrolovanom v\u00fdskumnom alebo laborat\u00f3rnom prostred\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>VIP je syntetick\u00fd line\u00e1rny polypeptid s dvadsiatimi \u00f4smimi aminokyselinov\u00fdmi zvy\u0161kami (C<sub>147<\/sub>H<sub>237<\/sub>N<sub>43<\/sub>O<sub>43<\/sub>S, pribli\u017ene 3326,8 g\/mol), ktor\u00e1 v roztoku predpoklad\u00e1 \u03b1-helik\u00e1lnu konform\u00e1ciu na ve\u013ekej \u010dasti re\u0165azca. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina v peptidovej ch\u00e9mii a analytick\u00fdch pr\u00e1cach. Ur\u010den\u00e9 v\u00fdlu\u010dne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie na pou\u017eitie u \u013eud\u00ed alebo zvierat. Nie je to liek.<\/p>","protected":false},"featured_media":3264,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,121],"product_tag":[],"class_list":["post-2804","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2804"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2804\/revisions"}],"predecessor-version":[{"id":2884,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2804\/revisions\/2884"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3264"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2804"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2804"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2804"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}