{"id":2791,"date":"2026-09-01T09:27:04","date_gmt":"2026-09-01T09:27:04","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2791"},"modified":"2026-09-02T14:08:05","modified_gmt":"2026-09-02T14:08:05","slug":"hcg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/hcg\/","title":{"rendered":"HCG"},"content":{"rendered":"<h2>\u010co je HCG?<\/h2>\n<p>HCG je dim\u00e9rny glykoprote\u00edn: dva nekovalentne viazan\u00e9 prote\u00ednov\u00e9 re\u0165azce, ktor\u00e9 spolu tvoria jeden komplex s celkovou molekulovou hmotnos\u0165ou pribli\u017ene 36 700 Da. Zl\u00fa\u010denina je zn\u00e1ma pod \u010d\u00edslom CAS 9002-61-3. \u03b1-podjednotka m\u00e1 dev\u00e4\u0165desiatdva aminokyselinov\u00fdch zvy\u0161kov; \u03b2-podjednotka je \u0161pecifick\u00e1 pre t\u00fato zl\u00fa\u010deninu. Pribli\u017ene jedna tretina molekulovej hmotnosti netvoria aminokyseliny, ale sacharidov\u00e9 re\u0165azce, a t\u00e1to glykozyl\u00e1cia do zna\u010dnej miery ur\u010duje skladanie a stabilitu intaktn\u00e9ho komplexu.<\/p>\n<p>Ke\u010f\u017ee ide o ve\u013ek\u00fd glykozylovan\u00fd prote\u00edn s dvoma podjednotkami, neexistuje jedin\u00fd empirick\u00fd vzorec ako pri mal\u00fdch molekul\u00e1ch: sacharidov\u00e9 re\u0165azce sa l\u00ed\u0161ia v zlo\u017een\u00ed, \u010do znamen\u00e1, \u017ee hmotnos\u0165 je sk\u00f4r distrib\u00facia ako jedno \u010d\u00edslo. Pr\u00e1ve to rob\u00ed z HCG in\u0161trukt\u00e1\u017enu modelov\u00fa zl\u00fa\u010deninu v r\u00e1mci ch\u00e9mie prote\u00ednov \u2013 je to dobre zdokumentovan\u00fd pr\u00edklad heterodim\u00e9rneho glykoprote\u00ednu, v ktorom je mo\u017en\u00e9 analyticky \u0161tudova\u0165 zostavenie podjednotiek, disulfidov\u00e9 most\u00edky, heterogenitu glyk\u00e1nov a distrib\u00faciu hmotnosti. Z rovnak\u00e9ho d\u00f4vodu sa obsah vyjadruje v medzin\u00e1rodn\u00fdch jednotk\u00e1ch (IU) a nie v miligramoch: to je \u0161tandardn\u00e1 jednotka \u0161pecifik\u00e1cie pre tento typ glykozylovan\u00e9ho prote\u00ednu.<\/p>\n<h2>Aplik\u00e1cie v laborat\u00f3rnom kontexte<\/h2>\n<p>V r\u00e1mci ch\u00e9mie prote\u00ednov a peptidov a analytick\u00fdch pr\u00e1c sa HCG nach\u00e1dza okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu in vitro:<\/p>\n<ul>\n<li><strong>V\u00fdskum vz\u0165ahu \u0161trukt\u00fary a aktivity<\/strong> pr\u00edspevku jednotliv\u00fdch podjednotiek a sacharidov\u00fdch re\u0165azcov k skladaniu, zostavovaniu a tepelnej stabilite intaktn\u00e9ho komplexu.<\/li>\n<li><strong>V\u00fdskum ch\u00e9mie prote\u00ednov a peptidov<\/strong> smerom k rozpustnosti, agrega\u010dn\u00e9mu spr\u00e1vaniu a disoci\u00e1cii podjednotiek heterodim\u00e9rnych glykoprote\u00ednov za r\u00f4znych podmienok pH a sol\u00ed.<\/li>\n<li><strong>\u0160t\u00fadie enzymatickej stability<\/strong> v ktorej sa systematicky porovn\u00e1va citlivos\u0165 prote\u00ednov\u00fdch re\u0165azcov a glyk\u00e1nov\u00fdch \u0161trukt\u00far na degrad\u00e1ciu in vitro.<\/li>\n<li><strong>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d<\/strong> (HPLC, LC-MS, mapovanie peptidov), kde materi\u00e1l sl\u00fa\u017ei ako referen\u010dn\u00fd \u0161tandard na stanovenie neporu\u0161enej hmotnosti, profilovanie glyk\u00e1nov a stanovenie obsahu v medzin\u00e1rodn\u00fdch jednotk\u00e1ch.<\/li>\n<\/ul>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>Vzorka<\/strong><\/td>\n<td>HCG<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0160trukt\u00fara<\/strong><\/td>\n<td>Dim\u00e9rny glykoprote\u00edn \u2014 \u03b1-podjednotka (92 aminokyselinov\u00fdch zvy\u0161kov) + \u0161pecifick\u00e1 \u03b2-podjednotka, nekovalentne viazan\u00e1<\/td>\n<\/tr>\n<tr>\n<td><strong>\u010c\u00edslo CAS<\/strong><\/td>\n<td>9002-61-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/strong><\/td>\n<td>\u017diadny jednoduch\u00fd hrub\u00fd vzorec (glykozylovan\u00fd prote\u00edn); pribli\u017ene 36 700 Da, z toho asi 30 % sacharidov<\/td>\n<\/tr>\n<tr>\n<td><strong>Trieda<\/strong><\/td>\n<td>Heterodim\u00e9rny glykoprote\u00edn<\/td>\n<\/tr>\n<tr>\n<td><strong>Formul\u00e1r<\/strong><\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej liekovke, \u0161tandardizovan\u00fd na medzin\u00e1rodn\u00e9 jednotky (IU)<\/td>\n<\/tr>\n<tr>\n<td><strong>Obsah<\/strong><\/td>\n<td>5 000 IU alebo 10 000 IU na injek\u010dn\u00fa liekovku<\/td>\n<\/tr>\n<tr>\n<td><strong>Skladovanie<\/strong><\/td>\n<td>Lyofilizovan\u00e9 pri teplote 2\u20138 \u00b0C, tmav\u00e9 a such\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Materi\u00e1l sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v uzavretej sklenenej liekovke s gumenou priehradkou a hlin\u00edkov\u00fdm zmr\u0161\u0165ovac\u00edm uz\u00e1verom, v dvoch v\u00fdskumn\u00fdch ve\u013ekostiach: 5 000 IU a 10 000 IU. Lyofiliz\u00e1t je biely a\u017e sivobiely a hygroskopick\u00fd. Liekovka zost\u00e1va uzavret\u00e1 a v p\u00f4vodnom obale, k\u00fdm sa materi\u00e1l nespracuje v laborat\u00f3riu.<\/p>\n<p>Uzavret\u00fd lyofiliz\u00e1t skladujte pri teplote 2 \u2013 8 \u00b0C na tmavom a suchom mieste, chr\u00e1nenom pred svetlom a vlhkos\u0165ou. Ke\u010f\u017ee dve podjednotky s\u00fa nekovalentne viazan\u00e9, komplex je citliv\u00fd na mechanick\u00e9 nam\u00e1hanie: kvapaln\u00fa vzorku jemne kr\u00fa\u017ete, nie ju silno traste, a vyh\u00fdbajte sa opakovan\u00fdm cyklom zmrazovania a rozmrazovania. Okrem toho s materi\u00e1lom manipulujte pod\u013ea be\u017en\u00fdch laborat\u00f3rnych opatren\u00ed: \u010dist\u00e9 pracovn\u00e9 prostredie, rukavice a ochrana o\u010d\u00ed a zvy\u0161n\u00fd materi\u00e1l zlikvidujte pod\u013ea platn\u00fdch pokynov.<\/p>\n<h2>Analytick\u00e1 kvalita<\/h2>\n<p>HCG je glykozylovan\u00fd prote\u00edn \u0161tandardizovan\u00fd na medzin\u00e1rodn\u00e9 jednotky (IU); percento \u010distoty HPLC, ako je be\u017en\u00e9 pre kr\u00e1tke syntetick\u00e9 peptidy, nie je vhodn\u00fdm meradlom pre tento typ zl\u00fa\u010deniny, preto\u017ee heterogenitu glyk\u00e1nov nemo\u017eno reprezentova\u0165 ako jeden ostr\u00fd p\u00edk. Materi\u00e1l sa preto dod\u00e1va pod\u013ea kontrolovanej \u0161pecifik\u00e1cie s dokument\u00e1ciou t\u00fdkaj\u00facou sa obsahu a identity dodanej \u0161ar\u017ee. Dostupn\u00e9 certifik\u00e1ty anal\u00fdzy si m\u00f4\u017eete pozrie\u0165 na na\u0161ej webovej str\u00e1nke. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>D\u00f4le\u017eit\u00e9 vyhl\u00e1senie o vyl\u00fa\u010den\u00ed zodpovednosti<\/h2>\n<p>Tento produkt dod\u00e1vame v\u00fdhradne na laborat\u00f3rny v\u00fdskum a analytick\u00e9 pr\u00e1ce. Nie je ur\u010den\u00fd na diagnostick\u00e9 ani terapeutick\u00e9 aplik\u00e1cie a v\u00fdslovne nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed alebo zvierat. Tento produkt nie je potravinou, doplnkom stravy, kozmetick\u00fdm v\u00fdrobkom ani registrovan\u00fdm liekom. K\u00fapou tohto produktu kupuj\u00faci potvrdzuje, \u017ee m\u00e1 18 rokov alebo viac a bude ho pou\u017e\u00edva\u0165 v\u00fdlu\u010dne v kontrolovanom v\u00fdskumnom alebo laborat\u00f3rnom prostred\u00ed.<\/p>","protected":false},"excerpt":{"rendered":"<p>HCG je dim\u00e9rny glykoprote\u00edn (CAS 9002-61-3) s molekulovou hmotnos\u0165ou pribli\u017ene 36 700 Da, zlo\u017een\u00fd z dvoch nekovalentne viazan\u00fdch podjednotiek, z ktor\u00fdch pribli\u017ene tretinu hmotnosti tvoria sacharidov\u00e9 re\u0165azce. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina v ch\u00e9mii prote\u00ednov a peptidov a v analytick\u00fdch pr\u00e1cach. Ur\u010den\u00fd v\u00fdlu\u010dne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie na pou\u017eitie u \u013eud\u00ed ani u zvierat. Nie je to liek.<\/p>","protected":false},"featured_media":3315,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[119,121],"product_tag":[],"class_list":["post-2791","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2791"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2791\/revisions"}],"predecessor-version":[{"id":2873,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2791\/revisions\/2873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3315"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2791"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2791"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2791"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}