Gonadorelin is a synthetic decapeptide, a chemically biterminally modified peptide with a pyroglutamyl start and a C-terminal glycinamide. In scientific research, it is studied as a model compound for receptor-linked peptide chemistry and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 2 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH, also referred to as LHRH) and consists of ten amino acids in the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub>The two ends are chemically unique. At the N-terminus, there is no free amine but a pyroglutamic acid: an intramolecularly cyclized glutamine in which the amino group is incorporated into a lactam ring. At the C-terminus, there is no free carboxylate but a glycinamide. Both ends are therefore electrically neutralized, meaning the net charge is determined entirely by the side chains, in practice primarily by the arginine at position 8 and the histidine at position 2. This charge neutralization simultaneously reduces the binding sites for amino- and carboxypeptidases.<\/p>\n In research models, Gonadorelin is used as a reference ligand for the GnRH receptor, a class A G-protein-coupled receptor. Because this peptide is the best-characterized ligand for that receptor, it serves as a reference point in binding studies using pituitary cell culture systems and membrane preparations when comparing modified analogs. Structural research focuses on the conformation in the binding groove: the glycine at position 6 allows for a tight bend. In vitro, the peptide is also a favored substrate for enzymological work, because degradation occurs selectively between glycine-6 \u200b\u200band leucine-7 and between proline-9 and the glycinamide. Consequently, Gonadorelin is used as a model compound and reference substance within scientific research.<\/p>\n In a laboratory context, Gonadorelin occurs in the following research areas, among others:<\/p>\n Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n Gonadorelin falls under the category of freeze-dried investigational compounds in vial form within our product range. While Gonadorelin focuses on a G-protein-coupled receptor and the influence of terminal modifications, other components within the same product line have been specifically chosen to cover enzymatic or metal-coordinated targets. These compounds share the freeze-dried vial form but differ fundamentally in molecular class and investigated mechanism.<\/p>\n Gonadorelin is supplied as a white freeze-dried powder of 2 mg per vial, sealed under a rubber stopper with aluminium sealing. With this small quantity, the lyophilisate is often barely visible as a thin layer at the bottom, which is normal in the milligram range. In a laboratory setting, the material is further processed according to the applicable analytical protocol.<\/p>\n Store the closed vial in a cool, dark place, protected from light and moisture, preferably in the original packaging. The tryptophan at position 3 is photosensitive and oxidizable, which makes protection against light and oxygen particularly relevant for this peptide. Handle the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination. Keep the packaging out of reach of unauthorized persons.<\/p>\n The lyophilisate contains 2 mg Gonadorelin per vial with a controlled purity of \u2265 99% (HPLC). No fillers or stabilizers are added, so that oxidation products can be attributed purely to the sample itself.<\/p>\nOblasti v\u00fdskumu<\/h2>\n
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Gonadorelin in our research assortment<\/h2>\n
\u0160pecifik\u00e1cie<\/h2>\n
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\n \n\u0160pecifik\u00e1cia<\/th>\n Hodnota<\/th>\n<\/tr>\n<\/thead>\n \n Vzorka<\/td>\n Gonadorelin<\/td>\n<\/tr>\n \n Synonym\u00e1<\/td>\n gonadotropin-releasing hormone (GnRH); LHRH; luliberin<\/td>\n<\/tr>\n \n Postupnos\u0165<\/td>\n pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2<\/sub><\/td>\n<\/tr>\n \n \u010c\u00edslo CAS<\/td>\n 33515-09-2<\/td>\n<\/tr>\n \n Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n C55<\/sub>H75<\/sub>N17<\/sub>O13<\/sub> \/ 1182.29 Da<\/td>\n<\/tr>\n \n PubChem CID<\/td>\n 638793<\/td>\n<\/tr>\n \n Trieda<\/td>\n Decapeptide; amidated at the C-terminus, cyclized at the N-terminus<\/td>\n<\/tr>\n \n Formul\u00e1r<\/td>\n Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofilizovan\u00fd pr\u00e1\u0161ok) v uzavretej liekovke<\/td>\n<\/tr>\n \n Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n 2 mg<\/td>\n<\/tr>\n \n Skladovanie<\/td>\n Skladujte na chladnom a tmavom mieste, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Tvar, manipul\u00e1cia a skladovanie<\/h2>\n
Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n