{"id":2788,"date":"2026-09-01T09:27:04","date_gmt":"2026-09-01T09:27:04","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2788"},"modified":"2026-09-02T12:17:13","modified_gmt":"2026-09-02T12:17:13","slug":"oxytocin-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/oxytocin-vial-10-mg\/","title":{"rendered":"Oxytocin vial 10 mg"},"content":{"rendered":"<p>Oxytoc\u00edn je endog\u00e9nny nonapeptid patriaci do rodiny neurohypofyze\u00e1lnych peptidov\u00fdch horm\u00f3nov; chemicky ide o cyklick\u00fd peptid s intramolekul\u00e1rnym disulfidov\u00fdm most\u00edkom. Vo vedeckom v\u00fdskume sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre receptorov\u00fa farmakol\u00f3giu a peptidov\u00fa ch\u00e9miu a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je oxytoc\u00edn?<\/h2>\n<p>Oxytoc\u00edn je peptid zlo\u017een\u00fd z deviatich aminokysel\u00edn so sekvenciou Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH.<sub>2<\/sub>Cyste\u00ednov\u00e9 zvy\u0161ky v poz\u00edci\u00e1ch 1 a 6 tvoria disulfidov\u00fd most\u00edk, \u010do sp\u00f4sobuje, \u017ee molekula nesie uzavret\u00fd kruh so \u0161iestimi aminokyselinami s chvostom z troch zvy\u0161kov a amidovan\u00fdm C-koncom. T\u00e1to kombin\u00e1cia pevn\u00e9ho kruhu a flexibiln\u00e9ho chvosta rob\u00ed zo zl\u00fa\u010deniny \u0161iroko pou\u017e\u00edvan\u00fd model pri \u0161t\u00fadiu rozpozn\u00e1vania peptidov\u00fdch receptorov.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa oxytoc\u00edn via\u017ee na oxytoc\u00ednov\u00fd receptor (OXTR), \u010do je receptor triedy A podobn\u00fd rodops\u00ednu so siedmimi transmembr\u00e1nov\u00fdmi dom\u00e9nami. In vitro sa tento receptor prim\u00e1rne via\u017ee na G prote\u00edny G1.<sub>11. \u0161tvr\u0165rok<\/sub>-typ, po ktorom fosfolip\u00e1za C tvor\u00ed membr\u00e1nov\u00fd lipid PIP<sub>2<\/sub> Rozklad\u00e1 sa na inozitoltrifosf\u00e1t a diacylglycerol; prv\u00fd z nich iniciuje uvo\u013e\u0148ovanie intracelul\u00e1rneho v\u00e1pnika v bunkov\u00fdch modeloch, zatia\u013e \u010do druh\u00fd aktivuje prote\u00ednkin\u00e1zu C. Ke\u010f\u017ee sa oxytoc\u00edn l\u00ed\u0161i od pr\u00edbuzn\u00fdch nonapeptidov tej istej horm\u00f3novej rodiny iba v dvoch poz\u00edci\u00e1ch, vykazuje tie\u017e slab\u0161iu skr\u00ed\u017een\u00fa reaktivitu s pr\u00edbuzn\u00fdmi receptorov\u00fdmi podtypmi v syst\u00e9moch bunkov\u00fdch kult\u00far. V d\u00f4sledku toho sa oxytoc\u00edn pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa oxytoc\u00edn vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>\u0160t\u00fadie v\u00e4zby oxytoc\u00ednov\u00e9ho receptora (OXTR) a afinity cyklick\u00fdch nonapeptidov k receptorom triedy A in vitro.<\/li>\n<li>V\u00fdskum G<sub>11. \u0161tvr\u0165rok<\/sub>viazan\u00e1 sign\u00e1lna transdukcia, aktivita fosfolip\u00e1zy C a mobiliz\u00e1cia v\u00e1pnika v izolovan\u00fdch bunkov\u00fdch modeloch.<\/li>\n<li>Anal\u00fdza \u0161trukt\u00fary a aktivity, v ktorej sa disulfid\u00e1cia a jednotliv\u00e9 zvy\u0161ky systematicky menia.<\/li>\n<li>Biofyzik\u00e1lne modelov\u00e9 \u0161t\u00fadie (NMR, cirkul\u00e1rny dichroizmus) priestorovej \u0161trukt\u00fary cyklick\u00fdch peptidov.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm oxytoc\u00ednu ako referen\u010dn\u00e9ho \u0161tandardu.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti peptidov obsahuj\u00facich disulfidy za kontrolovan\u00fdch podmienok teploty a pH.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>Oxytoc\u00edn v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>Oxytoc\u00edn patr\u00ed do kateg\u00f3rie lyofilizovan\u00fdch v\u00fdskumn\u00fdch peptidov vo forme liekoviek v r\u00e1mci n\u00e1\u0161ho sortimentu. V\u00fdskumn\u00edci v tejto kateg\u00f3rii pravidelne kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi peptidmi, ktor\u00e9 s\u00fa \u0161tudovan\u00e9 prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do oxytoc\u00edn je zameran\u00fd na receptor spriahnut\u00fd s G-prote\u00ednom triedy A, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli \u0161peci\u00e1lne vybran\u00e9 na pokrytie enzymatick\u00fdch alebo in\u00fdch receptorom sprostredkovan\u00fdch cie\u013eov. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia zlo\u017een\u00edm aminokysel\u00edn a sk\u00faman\u00fdm mechanizmom.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>Oxytoc\u00edn<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>a-hypofam\u00edn; ocytoc\u00edn; Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH<sub>2<\/sub> (cyklick\u00fd cez disulfidov\u00fd most\u00edk)<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>50-56-6<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub> \/ 1007,19 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>439302<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Cyklick\u00fd nonapeptid, neurohypofyze\u00e1lny peptidov\u00fd horm\u00f3n<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofilizovan\u00fd pr\u00e1\u0161ok (lyofiliz\u00e1t) v injek\u010dnej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uzavret\u00fa f\u013ea\u0161ti\u010dku skladujte na chladnom, suchom a tmavom mieste.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Oxytoc\u00edn sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok v uzavretej sklenenej liekovke obsahuj\u00facej \u0161tandardizovan\u00e9 mno\u017estvo 10 mg. Na rozdiel od pevnej tablety ide o lyofilizovan\u00fd materi\u00e1l: na analytick\u00e9 alebo bunkovo-biologick\u00e9 pr\u00e1ce sa materi\u00e1l rozp\u00fa\u0161\u0165a vo vhodnom rozp\u00fa\u0161\u0165adle. Pr\u00e1\u0161ok je hygroskopick\u00fd a po vystaven\u00ed okolit\u00e9mu vzduchu absorbuje vlhkos\u0165, \u010do ovplyv\u0148uje presnos\u0165 gravimetrick\u00fdch meran\u00ed.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte na chladnom a suchom mieste, chr\u00e1nenom pred priamym svetlom, v p\u00f4vodnom obale; disulfidov\u00fd most\u00edk je najcitlivej\u0161ou \u0161trukt\u00farou v molekule, preto je potrebn\u00e9 minimalizova\u0165 oxida\u010dn\u00e9 a tepeln\u00e9 stresov\u00e9 nap\u00e4tie. So zl\u00fa\u010deninou manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t dosahuje kontrolovan\u00fa \u010distotu \u2265 99 % (HPLC). F\u013ea\u0161ti\u010dka obsahuje peptid ako lyofilizovan\u00fd materi\u00e1l bez akt\u00edvnych ved\u013eaj\u0161\u00edch zlo\u017eiek.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej skupiny l\u00e1tok patr\u00ed oxytoc\u00edn?<\/strong><br \/>Oxytoc\u00edn je cyklick\u00fd nonapeptid patriaci do rodiny neurohypofyze\u00e1lnych peptidov\u00fdch horm\u00f3nov. Sklad\u00e1 sa z deviatich aminokysel\u00edn tvoren\u00fdch disulfidov\u00fdm most\u00edkom za vzniku kruhovej \u0161trukt\u00fary.<\/p>\n<p><strong>Ak\u00e1 je \u00faloha disulfidov\u00e9ho most\u00edka vo v\u00fdskume?<\/strong><br \/>Most\u00edk medzi cyste\u00ednmi v poz\u00edci\u00e1ch 1 a 6 ur\u010duje konform\u00e1ciu a do zna\u010dnej miery ur\u010duje rozpoznanie receptorov\u00fdm prote\u00ednom in vitro. Jeho redukcia alebo oxid\u00e1cia je preto opakovan\u00fdm zameran\u00edm v \u0161t\u00fadi\u00e1ch \u0161trukt\u00fary, aktivity a stability.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e9 pripojenie?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg v uzavretej sklenenej injek\u010dnej liekovke.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chlade, suchu a chr\u00e1nen\u00e9 pred svetlom, najlep\u0161ie v p\u00f4vodnom obale. Aj po rozpusten\u00ed zost\u00e1va materi\u00e1l chladn\u00fd a tmav\u00fd.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong>Oxytoc\u00edn<\/strong> je endog\u00e9nny cyklick\u00fd peptid pozost\u00e1vaj\u00faci z 9 aminokysel\u00edn, ktor\u00fd produkuj\u00fa magnocelul\u00e1rne neur\u00f3ny paraventrikul\u00e1rnych a supraoptick\u00fdch jadier hypotalamu a uvo\u013e\u0148uje sa cez neurohypof\u00fdzu. V r\u00e1mci v\u00fdskumu sa sk\u00fama \u00faloha oxytoc\u00ednu v soci\u00e1lnych v\u00e4zb\u00e1ch, kontrakcii hladk\u00e9ho svalstva a neuropeptidovej signaliz\u00e1cii.<\/p>","protected":false},"featured_media":3251,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[119,121],"product_tag":[],"class_list":["post-2788","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonaal-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2788","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2788"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2788\/revisions"}],"predecessor-version":[{"id":2864,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2788\/revisions\/2864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3251"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2788"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2788"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2788"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2788"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}