{"id":2767,"date":"2026-09-01T09:26:32","date_gmt":"2026-09-01T09:26:32","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2767"},"modified":"2026-09-02T16:56:08","modified_gmt":"2026-09-02T16:56:08","slug":"ghk-cu-en-snap-8-serum-35-ml","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/ghk-cu-en-snap-8-serum-35-ml\/","title":{"rendered":"S\u00e9rum GHK-Cu a SNAP-8 35 ml"},"content":{"rendered":"<p>S\u00e9rum GHK-Cu a SNAP-8 je dvojzlo\u017ekov\u00e1 referen\u010dn\u00e1 formul\u00e1cia syntetick\u00fdch peptidov, chemicky kombin\u00e1cia komplexu me\u010fnat\u00e9ho(II) tripeptidu a acetylovan\u00e9ho, \u200b\u200bC-termin\u00e1lne amidovan\u00e9ho oktapeptidu. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa formul\u00e1cia \u0161tuduje ako viaczlo\u017ekov\u00fd modelov\u00fd syst\u00e9m pre koordina\u010dn\u00fa ch\u00e9miu a stabilitu peptidov a ako referen\u010dn\u00e1 zmes v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako 35 ml vodn\u00e1 formul\u00e1cia, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je s\u00e9rum GHK-Cu a SNAP-8?<\/h2>\n<p>Prvou zlo\u017ekou je glycyl-L-histidyl-L-lyz\u00edn, koordinovan\u00fd s me\u010fnat\u00fdm(II) i\u00f3nom. Tripeptid via\u017ee kovov\u00fd i\u00f3n prostredn\u00edctvom imidazolov\u00e9ho at\u00f3mu dus\u00edka histid\u00ednov\u00e9ho zvy\u0161ku, deprotonovan\u00e9ho amidov\u00e9ho dus\u00edka z hlavn\u00e9ho re\u0165azca a N-termin\u00e1lnej aminoskupiny, \u010do vedie k tetragon\u00e1lne skreslen\u00e9mu koordina\u010dn\u00e9mu vzoru so \u0161tvorcovou rovinou. T\u00e1to geometria d\u00e1va komplexu absorp\u010dn\u00fd p\u00e1s dd okolo 500 \u2013 600 nm a rob\u00ed ho vysoko spektroskopicky sledovate\u013en\u00fdm. Druh\u00e1 zlo\u017eka, SNAP-8, je oktapeptid s acetylovan\u00fdm N-koncom a amidovan\u00fdm C-koncom; obe modifik\u00e1cie neutralizuj\u00fa n\u00e1boje na koncoch re\u0165azca, \u010d\u00edm zni\u017euj\u00fa celkov\u00fd n\u00e1boj a merate\u013ene menia reten\u010dn\u00e9 spr\u00e1vanie na inverzn\u00fdch f\u00e1zov\u00fdch kol\u00f3nach.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa sk\u00famaj\u00fa r\u00f4zne aspekty \u00fa\u010dinku jednotliv\u00fdch zlo\u017eiek: me\u010fnat\u00fd komplex ako model pre procesy z\u00e1visl\u00e9 od medi a pre expresiu zlo\u017eiek matrice vo fibroblastov\u00fdch bunkov\u00fdch modeloch a SNAP-8 ako \u0161truktur\u00e1lny anal\u00f3g N-termin\u00e1lneho segmentu prote\u00ednu SNAP-25 vo v\u00fdskume tvorby komplexov SNARE bez buniek. Ke\u010f\u017ee obe l\u00e1tky s\u00fa pr\u00edtomn\u00e9 v tej istej matrici, formul\u00e1cia s\u00fa\u010dasne predstavuje viaczlo\u017ekov\u00fa referen\u010dn\u00fa zmes: met\u00f3da, ktor\u00e1 zobrazuje oba p\u00edky \u00faplne oddelen\u00e9, dokazuje, \u017ee rozli\u0161ovacia schopnos\u0165 je dostato\u010dn\u00e1. V d\u00f4sledku toho sa t\u00e1to formul\u00e1cia vo vedeckom v\u00fdskume pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina aj ako referen\u010dn\u00e1 l\u00e1tka.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa s\u00e9rum GHK-Cu a SNAP-8 vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>\u0160t\u00fadie koordina\u010dnej ch\u00e9mie v\u00e4zbovej geometrie medi(II) na tripeptidy obsahuj\u00face histid\u00edn.<\/li>\n<li>V\u00fdvoj spektroskopickej met\u00f3dy s komplexom medi ako referen\u010dn\u00fdm bodom detekcie a kalibr\u00e1cie vo vidite\u013enej oblasti.<\/li>\n<li>\u0160t\u00fadia \u0161trukt\u00fary a aktivity zameran\u00e1 na vplyv N-termin\u00e1lnej acetyl\u00e1cie a C-termin\u00e1lnej amid\u00e1cie na distrib\u00faciu n\u00e1boja a konform\u00e1ciu.<\/li>\n<li>V\u00fdskum zostavovania SNARE komplexov a kompetit\u00edvnej v\u00e4zby peptidov v bezbunkov\u00fdch modelov\u00fdch syst\u00e9moch.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s formul\u00e1ciou ako viaczlo\u017ekov\u00e1 referen\u010dn\u00e1 zmes.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti peptidov a kovov\u00fdch komplexov vo vodnej matrici.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>S\u00e9rum GHK-Cu a SNAP-8 v na\u0161om v\u00fdskumnom rade<\/h2>\n<p>V r\u00e1mci n\u00e1\u0161ho sortimentu patr\u00ed t\u00e1to formul\u00e1cia medzi lok\u00e1lne v\u00fdskumn\u00e9 formul\u00e1cie: vodn\u00e9 matrice, v ktor\u00fdch s\u00fa \u00fa\u010dinn\u00e9 l\u00e1tky dod\u00e1van\u00e9 u\u017e rozpusten\u00e9. Zatia\u013e \u010do t\u00e1to formul\u00e1cia kombinuje dve \u00fa\u010dinn\u00e9 l\u00e1tky s r\u00f4znymi bodmi \u00fa\u010dinku, in\u00e9 zlo\u017eky v r\u00e1mci tej istej rady obsahuj\u00fa bu\u010f jednu definovan\u00fa \u00fa\u010dinn\u00fa l\u00e1tku, alebo \u00fa\u010dinn\u00fa l\u00e1tku z inej molekul\u00e1rnej triedy. Zdie\u013eaj\u00fa tekut\u00fa formu, ale l\u00ed\u0161ia sa zlo\u017een\u00edm a sk\u00faman\u00fdm mechanizmom \u00fa\u010dinku.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>GHK-Cu a SNAP-8 s\u00e9rum, 35 ml<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Me\u010fnat\u00fd tripeptid-1; Acetylglutamyl oktapeptid-3<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>89030-95-5 (komplex medi) \/ 49557-75-7 (vo\u013en\u00fd tripeptid); 868844-74-0<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>14<\/sub>H<sub>22<\/sub>CuN<sub>6<\/sub>O<sub>4<\/sub> \/ 401,91 Da; C<sub>41<\/sub>H<sub>70<\/sub>N<sub>16<\/sub>O<sub>16<\/sub>S \/ 1075,16 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>165429100 (komplex medi)<\/td>\n<\/tr>\n<tr>\n<td>Postupnos\u0165<\/td>\n<td>Gly-His-Lys (+ Cu)<sup>2+<\/sup>); Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Komplex kovov\u00fdch peptidov a modifikovan\u00fd syntetick\u00fd oktapeptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Vodn\u00e1 formul\u00e1cia s konzerva\u010dnou l\u00e1tkou<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na jednotku<\/td>\n<td>35 ml na f\u013ea\u0161u<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chlade pri teplote 2\u20138 \u00b0C, chr\u00e1\u0148te pred priamym svetlom.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Pr\u00edpravok sa dod\u00e1va ako \u010d\u00edra a\u017e svetlomodr\u00e1 kvapalina v 35 ml injek\u010dnej liekovke; farba je v\u00fdsledkom absorpcie meden\u00e9ho centra ligandov\u00fdm po\u013eom. Obe \u00fa\u010dinn\u00e9 l\u00e1tky s\u00fa u\u017e rozpusten\u00e9, tak\u017ee pr\u00edpravok sa m\u00f4\u017ee pou\u017ei\u0165 ako kvapaln\u00e1 vzorka bez predbe\u017enej \u00fapravy. Presn\u00e9 koncentr\u00e1cie s\u00fa poskytnut\u00e9 na po\u017eiadanie.<\/p>\n<p>F\u013ea\u0161ti\u010dku skladujte v chlade pri teplote 2 \u2013 8 \u00b0C, chr\u00e1\u0148te pred svetlom a teplom a po ka\u017edom odbere vzorky ju uzavrite; vodn\u00e9 peptidov\u00e9 matrice s\u00fa citliv\u00e9 na kol\u00edsanie teploty a mikrobi\u00e1lnu kontamin\u00e1ciu. S formul\u00e1ciou manipulujte s be\u017en\u00fdmi laborat\u00f3rnymi opatreniami: \u010dist\u00e9 prostredie, vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky, odber vzoriek s \u010dist\u00fdm vybaven\u00edm a mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Suroviny v tejto recept\u00fare s\u00fa v\u00fdskumnej kvality a pon\u00fakaj\u00fa sa s kontrolovanou \u010distotou \u2265 99 % (HPLC). V pr\u00edpade me\u010fnat\u00e9ho komplexu ur\u010duje spektroskopick\u00fd profil stechiometria medzi tripeptidom a kovov\u00fdm i\u00f3nom.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>, kde sa centr\u00e1lne zhroma\u017e\u010fuj\u00fa spr\u00e1vy.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patria tieto dve zlo\u017eky?<\/strong><br \/>Prv\u00fdm je komplex kov-peptid: tripeptid, ktor\u00fd koordinuje i\u00f3n medi(II). Druh\u00fdm je syntetick\u00fd oktapeptid s acetylovan\u00fdm N-koncom a amidovan\u00fdm C-koncom.<\/p>\n<p><strong>Pre\u010do je koordina\u010dn\u00e1 geometria relevantn\u00e1?<\/strong><br \/>Okolo i\u00f3nu medi(II) ur\u010duje energiu dd spojov a t\u00fdm aj absorp\u010dn\u00fd p\u00e1s okolo 500 \u2013 600 nm; tento p\u00e1s je priamym indik\u00e1torom integrity koordin\u00e1cie.<\/p>\n<p><strong>V akej forme sa pr\u00edpravok dod\u00e1va?<\/strong><br \/>Ako vodn\u00e1 formul\u00e1cia s objemom 35 ml s konzerva\u010dnou l\u00e1tkou, v ktorej s\u00fa obe \u00fa\u010dinn\u00e9 l\u00e1tky u\u017e pr\u00edtomn\u00e9 v rozpustenej forme.<\/p>\n<p><strong>Ako si ulo\u017e\u00edm znenie?<\/strong><br \/>Uchov\u00e1vajte v chlade pri teplote 2\u20138 \u00b0C, chr\u00e1\u0148te pred priamym svetlom a teplom, s d\u00f4kladne uzavretou f\u013ea\u0161ou.<\/p>","protected":false},"excerpt":{"rendered":"<p>Topick\u00e9 experiment\u00e1lne s\u00e9rum, ktor\u00e9 kombinuje dva komplement\u00e1rne experiment\u00e1lne peptidy: <strong>GHK-Cu<\/strong> (komplex glycyl-L-histidyl-L-lyz\u00edn + me\u010f) pre modely extracelul\u00e1rnej matrice a <strong>SNAP-8<\/strong> (Acetyl Glutamyl Octapeptid-3) pre v\u00fdskum komplexu SNARE. T\u00e1to kombin\u00e1cia sa sk\u00fama v r\u00e1mci v\u00fdskumu sprievodn\u00fdch \u00fa\u010dinkov na modely kolag\u00e9nu\/elast\u00ednu a signaliz\u00e1ciu buniek mimick\u00e9ho svalstva.<\/p>","protected":false},"featured_media":3333,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[136],"product_tag":[],"class_list":["post-2767","product","type-product","status-publish","has-post-thumbnail","product_cat-topicals","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2767"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2767\/revisions"}],"predecessor-version":[{"id":2831,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2767\/revisions\/2831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3333"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2767"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2767"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2767"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}