{"id":2612,"date":"2026-09-01T09:15:26","date_gmt":"2026-09-01T09:15:26","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2612"},"modified":"2026-09-02T12:18:22","modified_gmt":"2026-09-02T12:18:22","slug":"foxo4-dri-10mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/foxo4-dri-10mg\/","title":{"rendered":"FOXO4-DRI 10 mg"},"content":{"rendered":"<p>FOXO4-DRI je syntetick\u00fd v\u00fdskumn\u00fd peptid, chemicky D-retro-inverzn\u00fd peptid odvoden\u00fd z v\u00e4zbovej oblasti p53 transkrip\u010dn\u00e9ho faktora FOXO4. V r\u00e1mci vedeck\u00e9ho v\u00fdskumu sa \u0161tuduje ako modelov\u00e1 zl\u00fa\u010denina pre interakcie prote\u00edn-prote\u00edn a ako referen\u010dn\u00fd \u0161tandard v analytick\u00fdch pr\u00e1cach. T\u00e1to zl\u00fa\u010denina sa pon\u00faka ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku, v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely.<\/p>\n<h2>\u010co je FOXO4-DRI?<\/h2>\n<p>FOXO4-DRI, tie\u017e ozna\u010dovan\u00fd v\u00fdvojov\u00fdm k\u00f3dom Proxofim, je syntetick\u00fd peptid s molekulov\u00fdm vzorcom C<sub>228<\/sub>H<sub>388<\/sub>N<sub>86<\/sub>O<sub>64<\/sub> a molekulovou hmotnos\u0165ou pribli\u017ene 5 358 Da. Zl\u00fa\u010denina je odvoden\u00e1 od tej \u010dasti transkrip\u010dn\u00e9ho faktora FOXO4 (Forkhead box O4), ktor\u00e1 zabezpe\u010duje v\u00e4zbu na prote\u00edn p53. Charakteristick\u00e1 je D-retro-inverzn\u00e1 \u0161trukt\u00fara: sekvencia aminokysel\u00edn je obr\u00e1ten\u00e1 a v\u0161etky aminokyseliny boli nahraden\u00e9 ich zrkadlovou D-formou. V d\u00f4sledku toho priestorov\u00e9 usporiadanie bo\u010dn\u00fdch re\u0165azcov zost\u00e1va porovnate\u013en\u00e9 s p\u00f4vodn\u00fdm L-peptidom, zatia\u013e \u010do re\u0165azec je ove\u013ea menej n\u00e1chyln\u00fd na degrad\u00e1ciu prote\u00e1zami. T\u00e1to kombin\u00e1cia rob\u00ed z FOXO4-DRI \u0161iroko pou\u017e\u00edvan\u00fd model pri \u0161t\u00fadiu peptidomimet\u00edk a stabilizovan\u00fdch inhib\u00edtorov interakci\u00ed prote\u00edn-prote\u00edn.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch je FOXO4-DRI op\u00edsan\u00fd ako antagonista interakcie medzi FOXO4 a p53. V bunkov\u00fdch modeloch, v ktor\u00fdch bola indukovan\u00e1 bunkov\u00e1 senescencia, tieto dva prote\u00edny tvoria komplexy v bunkovom jadre; in vitro peptid nar\u00fa\u0161a t\u00fato tvorbu komplexu, po \u010dom sa p53 distribuuje odli\u0161ne v bunke a iniciuje sa vn\u00fatorn\u00e1 dr\u00e1ha mitochondri\u00e1lnej apopt\u00f3zy. Ke\u010f\u017ee sa to selekt\u00edvne pozoruje v senescentn\u00fdch bunk\u00e1ch v kultiva\u010dn\u00fdch syst\u00e9moch, a nie v norm\u00e1lne sa deliacich bunk\u00e1ch, zl\u00fa\u010denina je u\u017eito\u010dn\u00fdm n\u00e1strojom na anal\u00fdzu tejto selektivity. V d\u00f4sledku toho sa FOXO4-DRI pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa FOXO4-DRI vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>V\u00fdskum interakcie prote\u00edn-prote\u00edn medzi FOXO4 a p53 a jej naru\u0161enie v izolovan\u00fdch bunkov\u00fdch modeloch in vitro.<\/li>\n<li>Mechanistick\u00fd bunkov\u00fd biologick\u00fd v\u00fdskum vn\u00fatornej, mitochondri\u00e1lne sprostredkovanej dr\u00e1hy apopt\u00f3zy v kultiva\u010dn\u00fdch syst\u00e9moch.<\/li>\n<li>\u0160t\u00fadie biofyzik\u00e1lnych modelov D-retro-inverzn\u00fdch peptidov a vz\u0165ah medzi \u0161trukt\u00farou a aktivitou medzi zrkadlov\u00fdm obrazom a prirodzen\u00fdmi aminokyselinov\u00fdmi sekvenciami.<\/li>\n<li>Modelov\u00e9 \u0161t\u00fadie subcelul\u00e1rnej lokaliz\u00e1cie transkrip\u010dn\u00fdch faktorov a ich v\u00e4zbov\u00fdch partnerov v syst\u00e9moch bunkov\u00fdch kult\u00far.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm FOXO4-DRI ako referen\u010dn\u00e9ho \u0161tandardu.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti peptidov rezistentn\u00fdch na prote\u00e1zy za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>FOXO4-DRI v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>FOXO4-DRI patr\u00ed do kateg\u00f3rie lyofilizovan\u00fdch v\u00fdskumn\u00fdch peptidov vo forme liekoviek v r\u00e1mci n\u00e1\u0161ho sortimentu. V\u00fdskumn\u00edci pracuj\u00faci s touto kateg\u00f3riou \u010dasto kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi peptidmi \u0161tudovan\u00fdmi prostredn\u00edctvom ich vlastn\u00e9ho biochemick\u00e9ho cie\u013ea. Zatia\u013e \u010do FOXO4-DRI sa zameriava na naru\u0161enie \u0161pecifickej interakcie prote\u00edn-prote\u00edn, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 \u0161peci\u00e1lne na pokrytie cie\u013eov viazan\u00fdch na receptory alebo enzymatick\u00fdch cie\u013eov. Tieto zl\u00fa\u010deniny maj\u00fa rovnak\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia molekul\u00e1rnou \u0161trukt\u00farou a sk\u00faman\u00fdm mechanizmom.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>FOXO4-DRI<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Proxofim; FOXO4 D-retroinverzn\u00fd peptid<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>228<\/sub>H<sub>388<\/sub>N<sub>86<\/sub>O<sub>64<\/sub> \/ \u2248 5358 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>167312269<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd D-retro-inverzn\u00fd peptid; antagonista interakcie FOXO4\u2013p53<\/td>\n<\/tr>\n<tr>\n<td>Forma<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ok)<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Po\u010det liekoviek v balen\u00ed<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1\u0148te pred svetlom a vlhkos\u0165ou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>FOXO4-DRI sa dod\u00e1va ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg na injek\u010dn\u00fa liekovku. Tento lyofiliz\u00e1t sa pred anal\u00fdzou umiestni do vhodn\u00e9ho rozp\u00fa\u0161\u0165adla v laborat\u00f3rnom zariaden\u00ed.<\/p>\n<p>Injek\u010dn\u00fa liekovku skladujte v chladni\u010dke, chr\u00e1nen\u00fa pred priamym svetlom a vlhkos\u0165ou, v p\u00f4vodnom obale. So zl\u00fa\u010deninou manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Tento lyofiliz\u00e1t dosahuje kontrolovan\u00fa \u010distotu \u2265 99 % (HPLC). Injek\u010dn\u00e1 liekovka obsahuje peptid ako such\u00fa l\u00e1tku bez pridan\u00fdch pomocn\u00fdch l\u00e1tok.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed FOXO4-DRI?<\/strong><br \/>FOXO4-DRI je syntetick\u00fd peptid zlo\u017een\u00fd z D-aminokysel\u00edn v obr\u00e1tenom porad\u00ed, pri\u010dom t\u00e1to kon\u0161trukcia sa v literat\u00fare ozna\u010duje ako D-retro-inverzo. Ide teda o peptid s relat\u00edvne vysokou molekulovou hmotnos\u0165ou pribli\u017ene 5 358 Da.<\/p>\n<p><strong>\u010co presne znamen\u00e1 \u0161trukt\u00fara D-retro-inverzia?<\/strong><br \/>Aminokyselinov\u00e1 sekvencia p\u00f4vodn\u00e9ho peptidu je obr\u00e1ten\u00e1 a ka\u017ed\u00e1 aminokyselina je nahraden\u00e1 jej zrkadlov\u00fdm D variantom. T\u00e1to dvojit\u00e1 reverzia vedie k re\u0165azcu, v ktorom bo\u010dn\u00e9 re\u0165azce zost\u00e1vaj\u00fa priestorovo podobne orientovan\u00e9, zatia\u013e \u010do peptidov\u00e9 v\u00e4zby s\u00fa pre prote\u00e1zy ove\u013ea \u0165a\u017e\u0161ie rozpoznate\u013en\u00e9.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e1 zl\u00fa\u010denina?<\/strong><br \/>Ako lyofilizovan\u00fd pr\u00e1\u0161ok s hmotnos\u0165ou 10 mg v uzavretej injek\u010dnej liekovke, jedna injek\u010dn\u00e1 liekovka v balen\u00ed.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 injek\u010dn\u00fa liekovku?<\/strong><br \/>Skladujte v chladni\u010dke, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou a najlep\u0161ie v p\u00f4vodnom obale. Obmedzte po\u010det zmien teploty.<\/p>","protected":false},"excerpt":{"rendered":"<p>FOXO4-DRI (tie\u017e zn\u00e1my ako Proxofim) je syntetick\u00fd D-retro-inverzn\u00fd peptid zlo\u017een\u00fd z v\u00e4zbovej dom\u00e9ny p53 transkrip\u010dn\u00e9ho faktora FOXO4. V s\u00fa\u010dasnosti sa sk\u00fama ako modelov\u00e1 zl\u00fa\u010denina v r\u00e1mci vedeck\u00e9ho v\u00fdskumu. Je ur\u010den\u00fd v\u00fdhradne na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely; nie je ur\u010den\u00fd na \u013eudsk\u00fa ani \u017eivo\u010d\u00ed\u0161nu spotrebu. Nie je to liek ani doplnok stravy.<\/p>","protected":false},"featured_media":3262,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2612","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2612"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2612\/revisions"}],"predecessor-version":[{"id":2692,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2612\/revisions\/2692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3262"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2612"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2612"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2612"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}