{"id":2407,"date":"2026-09-01T09:01:43","date_gmt":"2026-09-01T09:01:43","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2407"},"modified":"2026-09-02T09:00:22","modified_gmt":"2026-09-02T09:00:22","slug":"cortagen-neusspray-kit","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/cortagen-neusspray-kit\/","title":{"rendered":"S\u00faprava na nosov\u00fd sprej Cortagen"},"content":{"rendered":"<p><strong>Len na laborat\u00f3rne a v\u00fdskumn\u00e9 \u00fa\u010dely. Nie je ur\u010den\u00e9 na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.<\/strong><\/p>\n<p>Cortagen is a synthetic tetrapeptide from the class of short peptide bioregulators that is studied in controlled laboratory settings within the context of peptide-mediated signaling pathways and molecular regulatory systems. In scientific research, the compound is used as a model compound in analytical work. This compound is offered as a freeze-dried lyophilisate in a sealed 20 mg research vial, supplied as part of a composite research kit.<\/p>\n<h2>What is Cortagen?<\/h2>\n<p>Cortagen is a tetrapeptide composed of the amino acids alanine, glutamic acid, aspartic acid, and proline (Ala-Glu-Asp-Pro, abbreviated as AEDP). The two acidic side chains of glutamic acid and aspartic acid give the molecule a pronounced negative net charge in aqueous media, while the C-terminal proline residue with its pyrrolidine ring restricts the rotational freedom of the peptide chain. This combination of charge distribution and conformational restriction yields a small, sharply defined molecular profile.<\/p>\n<p>In research models, Cortagen is studied within the class of short peptide bioregulators, which are described in the literature as being able to associate with double-stranded DNA in promoter regions in cell culture systems and are thus linked to transcriptional regulatory mechanisms. This target is investigated exclusively in vitro and in preclinical model systems. Consequently, Cortagen is used as a model compound and reference substance within scientific research.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>In a laboratory context, Cortagen occurs in the following research areas, among others:<\/p>\n<ul>\n<li>Research into peptide-DNA interaction and the complementarity between short amino acid sequences and nucleotide motifs in promoter regions.<\/li>\n<li>\u0160t\u00fadie peptidmi sprostredkovan\u00fdch sign\u00e1lnych dr\u00e1h a molekul\u00e1rnych regula\u010dn\u00fdch siet\u00ed v kontrolovan\u00fdch bunkov\u00fdch modeloch in vitro.<\/li>\n<li>Structure-activity relationship research on tetrapeptides and the contribution of individual amino acid residues to charge distribution.<\/li>\n<li>Conformation and stability study in which the influence of the C-terminal proline residue on the peptide conformation is modeled.<\/li>\n<li>Analytical method development and validation (HPLC, LC-MS, capillary electrophoresis) using Cortagen as the reference standard.<\/li>\n<li>Comparative study within the class of short peptide bioregulators under controlled conditions.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>Analytick\u00e1 \u0161pecifik\u00e1cia<\/h2>\n<p>The material is submitted with a controlled purity of \u2265 99%, determined via high-pressure liquid chromatography (HPLC). Identity and purity are determining parameters in analytical peptide work: in short, highly charged sequences, impurities or degradation products can shift the retention time and thereby influence the interpretation of measurement results. An overview of the available analysis documentation can be found on our <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>Cortagen<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>AEDP; H-Ala-Glu-Asp-Pro-OH<\/td>\n<\/tr>\n<tr>\n<td>Postupnos\u0165<\/td>\n<td>Ala-Glu-Asp-Pro (AEDP)<\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>335591-03-2<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>18439621<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>17<\/sub>H<sub>26<\/sub>N<sub>4<\/sub>O<sub>9<\/sub> \/ \u00b1 430.4 Da<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Synthetic tetrapeptide (short peptide bioregulator)<\/td>\n<\/tr>\n<tr>\n<td>Forma<\/td>\n<td>Lyofiliz\u00e1t su\u0161en\u00fd mrazom v uzavretej liekovke<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>\u010cistota<\/td>\n<td>\u2265 99 % (HPLC)<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Skladujte na chladnom a tmavom mieste, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>Cortagen is supplied as freeze-dried lyophilisate in a sealed vial containing 20 mg. The vial is part of a composite research kit which also includes a sterile physiological saline solution (NaCl 0.9%) and an empty spray bottle; reconstitution is applicable to this material. The lyophilization process preserves the molecular integrity of the peptide during storage and transport. The powder is white to off-white and dissolves readily in aqueous media due to the two acidic side chains.<\/p>\n<p>Store the sealed lyophilisate in a cool, dry, and dark place in the original packaging, protected from light and moisture. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, prevent cross-contamination with other research materials, and keep the packaging out of reach of unauthorized persons.<\/p>\n<h2>Cortagen in our research assortment<\/h2>\n<p>Cortagen falls under the category of freeze-dried investigational compounds in vial form within our range. Researchers working with this category frequently combine the compound with other peptides that are studied via their own molecular target. While Cortagen distinguishes itself through its short, highly charged sequence, other components within the same product line have been specifically chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried vial form but differ fundamentally in molecular class and investigated mechanism.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>To which class of substances does Cortagen belong?<\/strong><br \/>Cortagen is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Pro (AEDP) and belongs to the class of short peptide bioregulators.<\/p>\n<p><strong>Why is the sequence relevant in research?<\/strong><br \/>The two acidic side chains and the C-terminal proline residue give the molecule a defined charge distribution and limited conformational freedom. This makes the compound useful as a model in research into peptide-nucleic acid interactions and in analytical methods.<\/p>\n<p><strong>V akej forme je dod\u00e1van\u00e1 zl\u00fa\u010denina?<\/strong><br \/>As freeze-dried lyophilisate in a sealed 20 mg vial, with a purity of \u2265 99% (HPLC), as part of a composite research set.<\/p>\n<p><strong>What does the material look like?<\/strong><br \/>The lyophilisate is white to off-white; the highly charged side chains make the peptide highly soluble in aqueous media.<\/p>\n<p><strong>Ako m\u00e1m materi\u00e1l skladova\u0165?<\/strong><br \/>Store in a cool, dry, and dark place in the original packaging, protected from light and moisture.<\/p>","protected":false},"excerpt":{"rendered":"<p>Cortagen is a short synthetic peptide belonging to the cortex class of the so-called Khavinson peptides.<\/p>","protected":false},"featured_media":3102,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[133,131],"product_tag":[],"class_list":["post-2407","product","type-product","status-publish","has-post-thumbnail","product_cat-focus-cognitie","product_cat-neussprays","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2407"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2407\/revisions"}],"predecessor-version":[{"id":2473,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2407\/revisions\/2473"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3102"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2407"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2407"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2407"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}