{"id":2174,"date":"2026-09-01T08:43:06","date_gmt":"2026-09-01T08:43:06","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2174"},"modified":"2026-09-02T12:19:42","modified_gmt":"2026-09-02T12:19:42","slug":"ss-31-vial-10-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/sk\/product\/ss-31-vial-10-mg\/","title":{"rendered":"SS-31 injek\u010dn\u00e1 liekovka 10 mg"},"content":{"rendered":"<p>SS-31 is een synthetisch peptide uit de klasse van de mitochondriaal gerichte, aromatisch-kationische tetrapeptiden, chemisch een tetrapeptide-amide met een alternerend aromatisch-kationisch motief. Binnen wetenschappelijk onderzoek wordt het bestudeerd als modelverbinding voor mitochondriale membraanbiofysica en als referentiestandaard in analytisch werk. Deze verbinding wordt aangeboden als gevriesdroogd poeder van 10\u00a0mg per vial, uitsluitend voor laboratorium- en onderzoeksdoeleinden.<\/p>\n<h2>\u010co je SS-31?<\/h2>\n<p>SS-31 (Elamipretid, v\u00fdvojov\u00fd k\u00f3d MTP-131) je mal\u00fd syntetick\u00fd peptid so sekvenciou D-Arg-Dmt-Lys-Phe-NH.<sub>2<\/sub>, kde Dmt znamen\u00e1 2\u2032,6\u2032-dimetyltyroz\u00edn a C-koniec je zachovan\u00fd v amidovej skupine. \u0160tyri zvy\u0161ky sa striedaj\u00fa v charaktere: dva z\u00e1sadit\u00e9, kladne nabit\u00e9 zvy\u0161ky (D-argin\u00edn a lyz\u00edn) s\u00fa oproti dvom aromatick\u00fdm zvy\u0161kom. Tento striedav\u00fd aromaticko-kati\u00f3nov\u00fd vzor d\u00e1va molekule \u010dist\u00fd kladn\u00fd n\u00e1boj pri fyziologickom pH v kombin\u00e1cii s v\u00fdrazn\u00fdmi hydrof\u00f3bnymi povrchmi a pr\u00e1ve tento dvojit\u00fd podpis rob\u00ed z SS-31 \u0161iroko pou\u017e\u00edvan\u00fa modelov\u00fa molekulu pri \u0161t\u00fadiu interakci\u00ed peptid-membr\u00e1na.<\/p>\n<p>Vo v\u00fdskumn\u00fdch modeloch sa SS-31 prim\u00e1rne sk\u00fama pre svoju selekt\u00edvnu afinitu ku kardiolip\u00ednu, ani\u00f3nov\u00e9mu fosfolipidu, ktor\u00fd sa nach\u00e1dza takmer v\u00fdlu\u010dne vo vn\u00fatornej mitochondri\u00e1lnej membr\u00e1ne. T\u00e1to v\u00e4zba sa opiera o dve s\u00fa\u010dasne p\u00f4sobiace sily: elektrostatick\u00fa pr\u00ed\u0165a\u017elivos\u0165 medzi kati\u00f3nov\u00fdmi zvy\u0161kami a negat\u00edvne nabit\u00fdmi hlavn\u00fdmi skupinami kardiolip\u00ednu a hydrof\u00f3bnu inzerciu aromatick\u00fdch bo\u010dn\u00fdch re\u0165azcov do lipidovej vrstvy. In vitro bolo op\u00edsan\u00e9, \u017ee t\u00e1to interakcia ovplyv\u0148uje membr\u00e1nov\u00e9 balenie a n\u00e1sledne organiz\u00e1ciu prote\u00ednov\u00fdch komplexov ukotven\u00fdch v nej, vr\u00e1tane superkomplexov d\u00fdchacieho re\u0165azca. V d\u00f4sledku toho sa SS-31 pou\u017e\u00edva ako modelov\u00e1 zl\u00fa\u010denina a referen\u010dn\u00e1 l\u00e1tka vo vedeckom v\u00fdskume.<\/p>\n<h2>Oblasti v\u00fdskumu<\/h2>\n<p>V laborat\u00f3rnom kontexte sa SS-31 vyskytuje okrem in\u00e9ho v nasleduj\u00facich oblastiach v\u00fdskumu:<\/p>\n<ul>\n<li>Biofyzik\u00e1lny v\u00fdskum v\u00e4zby kati\u00f3nov\u00fdch peptidov na kardiolip\u00edn v lipoz\u00f3moch a modeloch umel\u00fdch membr\u00e1n.<\/li>\n<li>Modelov\u00e9 \u0161t\u00fadie stability superkomplexov mitochondri\u00e1lneho respira\u010dn\u00e9ho re\u0165azca v izolovan\u00fdch mitochondri\u00e1ch.<\/li>\n<li>Enzymologick\u00e9 sk\u00famanie peroxid\u00e1zovej aktivity kardiolip\u00edn-cytochr\u00f3mov\u00e9ho c komplexu in vitro.<\/li>\n<li>\u0160t\u00fadia \u0161trukt\u00fary a aktivity, v ktorej sa striedaj\u00faci sa aromatick\u00fd-kati\u00f3nov\u00fd mot\u00edv porovn\u00e1va s modifikovan\u00fdmi anal\u00f3gmi.<\/li>\n<li>V\u00fdvoj a valid\u00e1cia analytick\u00fdch met\u00f3d (HPLC, LC-MS) s pou\u017eit\u00edm SS-31 ako referen\u010dn\u00e9ho \u0161tandardu pre tetrapeptidy.<\/li>\n<li>\u0160t\u00fadie stability a rozpustnosti lyofilizovan\u00fdch peptidov s D-aminokyselinami za kontrolovan\u00fdch podmienok.<\/li>\n<\/ul>\n<p>Ka\u017ed\u00e1 z t\u00fdchto aplik\u00e1ci\u00ed zah\u0155\u0148a kontrolovan\u00fd laborat\u00f3rny alebo predklinick\u00fd modelov\u00fd v\u00fdskum.<\/p>\n<h2>SS-31 v na\u0161om v\u00fdskumnom sortimente<\/h2>\n<p>SS-31 patr\u00ed do kateg\u00f3rie lyofilizovan\u00fdch v\u00fdskumn\u00fdch peptidov vo forme liekoviek v r\u00e1mci n\u00e1\u0161ho sortimentu. V\u00fdskumn\u00edci pracuj\u00faci s touto kateg\u00f3riou \u010dasto kombinuj\u00fa t\u00fato zl\u00fa\u010deninu s in\u00fdmi peptidmi, ktor\u00e9 maj\u00fa svoj vlastn\u00fd biochemick\u00fd cie\u013e. Zatia\u013e \u010do SS-31 sa zameriava na interakciu so \u0161pecifick\u00fdm membr\u00e1nov\u00fdm fosfolipidom, in\u00e9 zlo\u017eky v r\u00e1mci tej istej produktovej rady boli vybran\u00e9 \u0161peci\u00e1lne na pokrytie cie\u013eov viazan\u00fdch na receptory alebo enzymatick\u00fdch cie\u013eov. Tieto zl\u00fa\u010deniny maj\u00fa lyofilizovan\u00fa formu liekoviek, ale z\u00e1sadne sa l\u00ed\u0161ia v aminokyselinovej sekvencii a sk\u00famanom mechanizme.<\/p>\n<h2>\u0160pecifik\u00e1cie<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0160pecifik\u00e1cia<\/th>\n<th>Hodnota<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Vzorka<\/td>\n<td>SS-31<\/td>\n<\/tr>\n<tr>\n<td>Synonym\u00e1<\/td>\n<td>Elamipretid; MTP-131; D-Arg-Dmt-Lys-Phe-NH<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>\u010c\u00edslo CAS<\/td>\n<td>736992-21-5<\/td>\n<\/tr>\n<tr>\n<td>Molekul\u00e1rny vzorec \/ hmotnos\u0165<\/td>\n<td>C<sub>32<\/sub>H<sub>49<\/sub>N<sub>9<\/sub>O<sub>5<\/sub> \/ 639,8 Da<\/td>\n<\/tr>\n<tr>\n<td>PubChem CID<\/td>\n<td>11764719<\/td>\n<\/tr>\n<tr>\n<td>Trieda<\/td>\n<td>Syntetick\u00fd aromatick\u00fd-kati\u00f3nov\u00fd tetrapeptid<\/td>\n<\/tr>\n<tr>\n<td>Formul\u00e1r<\/td>\n<td>Lyofiliz\u00e1t (lyofilizovan\u00fd pr\u00e1\u0161ok)<\/td>\n<\/tr>\n<tr>\n<td>Mno\u017estvo na injek\u010dn\u00fa liekovku<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>Skladovanie<\/td>\n<td>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1\u0148te pred svetlom a vlhkos\u0165ou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Tvar, manipul\u00e1cia a skladovanie<\/h2>\n<p>SS-31 wordt geleverd als gevriesdroogd, wit tot gebroken wit poeder in een afgesloten glazen vial met een gestandaardiseerde hoeveelheid van 10\u00a0mg. Dit lyofilisaat is bedoeld om in een laboratoriumopstelling in een geschikt oplosmiddel te worden opgenomen voordat verdere analyse plaatsvindt. Het poeder is hygroscopisch en neemt bij blootstelling aan omgevingslucht vocht op.<\/p>\n<p>Uzatvoren\u00fa injek\u010dn\u00fa liekovku skladujte v chladni\u010dke, chr\u00e1nen\u00fa pred priamym svetlom a vlhkos\u0165ou, v p\u00f4vodnom obale. S pripojen\u00edm manipulujte pod\u013ea \u0161tandardn\u00fdch laborat\u00f3rnych opatren\u00ed: pracujte v \u010distom prostred\u00ed, pred otvoren\u00edm nechajte liekovku dosiahnu\u0165 izbov\u00fa teplotu, aby sa minimalizovala kondenz\u00e1cia, pou\u017e\u00edvajte vhodn\u00e9 osobn\u00e9 ochrann\u00e9 prostriedky a zabr\u00e1\u0148te kr\u00ed\u017eovej kontamin\u00e1cii s in\u00fdmi v\u00fdskumn\u00fdmi materi\u00e1lmi. Obal uchov\u00e1vajte mimo dosahu neopr\u00e1vnen\u00fdch os\u00f4b.<\/p>\n<h2>Zlo\u017eenie a laborat\u00f3rne v\u00fdsledky<\/h2>\n<p>Pri tomto lyofiliz\u00e1te sa dodr\u017eiava kontrolovan\u00e1 \u010distota \u2265 99 % (HPLC), pri\u010dom identita je potvrden\u00e1 prostredn\u00edctvom prilo\u017eenej analytickej dokument\u00e1cie.<\/p>\n<p>Preh\u013ead dostupnej analytickej dokument\u00e1cie n\u00e1jdete na na\u0161ej <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">str\u00e1nka s v\u00fdsledkami laborat\u00f3rnych testov<\/a>Spr\u00e1vy sa tam zhroma\u017e\u010fuj\u00fa centr\u00e1lne, aby ste mohli \u00fadaje zahrn\u00fa\u0165 do vlastn\u00fdch v\u00fdskumn\u00fdch z\u00e1znamov.<\/p>\n<h2>\u010casto kladen\u00e9 ot\u00e1zky<\/h2>\n<p><strong>Do ktorej triedy l\u00e1tok patr\u00ed SS-31?<\/strong><br \/>SS-31 je syntetick\u00fd tetrapeptid so striedav\u00fdm aromaticko-kati\u00f3nov\u00fdm mot\u00edvom a C-termin\u00e1lnym amidom s definovanou aminokyselinovou sekvenciou \u0161tyroch zvy\u0161kov.<\/p>\n<p><strong>Ak\u00e1 je \u00faloha kardiolip\u00ednu v tejto \u0161t\u00fadii?<\/strong><br \/>Kardiolip\u00edn je ani\u00f3nov\u00fd fosfolipid, na ktor\u00fd sa SS-31 selekt\u00edvne via\u017ee in vitro. T\u00e1to v\u00e4zba je \u00fastredn\u00fdm zameran\u00edm mechanistick\u00e9ho laborat\u00f3rneho v\u00fdskumu organiz\u00e1cie membr\u00e1novo viazan\u00fdch prote\u00ednov\u00fdch komplexov v modelov\u00fdch syst\u00e9moch.<\/p>\n<p><strong>Pre\u010do sekvencia obsahuje D-argin\u00edn a metylovan\u00fd tyroz\u00edn?<\/strong><br \/>Obe modifik\u00e1cie robia peptid menej n\u00e1chyln\u00fdm na enzymatick\u00fa degrad\u00e1ciu in vitro a ovplyv\u0148uj\u00fa rozlo\u017eenie n\u00e1boja v molekule. V\u010faka tomu sl\u00fa\u017ei zl\u00fa\u010denina ako stabiln\u00fd referen\u010dn\u00fd bod v \u0161t\u00fadi\u00e1ch \u0161trukt\u00fary a aktivity.<\/p>\n<p><strong>Ako m\u00e1m skladova\u0165 lyofilizovan\u00fd pr\u00e1\u0161ok?<\/strong><br \/>Uchov\u00e1vajte v chladni\u010dke, chr\u00e1nen\u00e9 pred svetlom a vlhkos\u0165ou, najlep\u0161ie v p\u00f4vodne uzavretej liekovke. Zabr\u00e1\u0148te opakovan\u00fdm zmen\u00e1m teploty a kondenz\u00e1cii.<\/p>","protected":false},"excerpt":{"rendered":"<p><strong>SS-31<\/strong>, tie\u017e zn\u00e1my ako <strong>Elamipretid<\/strong>SS-31 je syntetick\u00fd tetrapeptid s unik\u00e1tnou aromaticko-kati\u00f3novou \u0161trukt\u00farou, ktor\u00e1 sa selekt\u00edvne akumuluje vo vn\u00fatornej mitochondri\u00e1lnej membr\u00e1ne. Vo v\u00fdskume sa sk\u00fama v\u00e4zba SS-31 na kardiolip\u00edn a jeho \u00faloha v modeloch mitochondri\u00e1lnej dysfunkcie.<\/p>","protected":false},"featured_media":3272,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[120,121],"product_tag":[],"class_list":["post-2174","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/comments?post=2174"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2174\/revisions"}],"predecessor-version":[{"id":2209,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product\/2174\/revisions\/2209"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media\/3272"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/media?parent=2174"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_brand?post=2174"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_cat?post=2174"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/sk\/wp-json\/wp\/v2\/product_tag?post=2174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}