{"id":2819,"date":"2026-09-01T09:29:42","date_gmt":"2026-09-01T09:29:42","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2819"},"modified":"2026-09-02T12:24:37","modified_gmt":"2026-09-02T12:24:37","slug":"selank","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/ro\/product\/selank\/","title":{"rendered":"Selank"},"content":{"rendered":"<h2>Ce este Selank?<\/h2>\n<p>Selank este o heptapeptid\u0103 liniar\u0103 sintetic\u0103 cu secven\u021ba de aminoacizi Thr-Lys-Pro-Arg-Pro-Gly-Pro. Lan\u021bul este format dintr-un motiv tetrapeptidic natural (Thr-Lys-Pro-Arg) de care tripeptida Pro-Gly-Pro este ata\u0219at\u0103 la cap\u0103tul C-terminal. Compusul poart\u0103 num\u0103rul CAS 129954-34-3 \u0219i are formula molecular\u0103 C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \u0219i o mas\u0103 molecular\u0103 de aproximativ 751,9 Da (PubChem CID 11765600).<\/p>\n<p>Cu trei reziduuri de prolin\u0103 la \u0219apte pozi\u021bii, Selank este o secven\u021b\u0103 distinct bogat\u0103 \u00een prolin\u0103. Prolina limiteaz\u0103 libertatea de rota\u021bie a coloanei vertebrale, iar secven\u021ba prolin\u0103-glicin\u0103-prolin\u0103 de la cap\u0103tul C-terminal cre\u0219te rigiditatea acelui cap\u0103t, limit\u00e2nd astfel atacul exopeptidazelor; \u00een condi\u021bii de laborator, acest lucru face ca lan\u021bul s\u0103 fie considerabil mai stabil dec\u00e2t motivul tetrapeptidic neextins, care se degradeaz\u0103 rapid \u00een sisteme tampon definite. Mai mult, dou\u0103 reziduuri puternic bazice - lizina \u0219i arginina - confer\u0103 moleculei un punct izoelectric ridicat \u0219i un caracter distinct hidrofil, \u00een timp ce lan\u021bul nu con\u021bine niciun reziduu aromatic. Prin urmare, detec\u021bia nu se bazeaz\u0103 pe absorb\u021bia la 280 nm, ci pe leg\u0103tura peptidic\u0103 \u00een sine \u00een jurul a 210-220 nm. Aceast\u0103 combina\u021bie de rigiditate a lan\u021bului, hidrofilicitate ridicat\u0103 \u0219i absen\u021ba unui cromofor face din Selank un compus model instructiv \u00een cercetarea comparativ\u0103 a peptidelor \u0219i \u00een dezvoltarea metodelor analitice.<\/p>\n<h2>Aplica\u021bii \u00een context de laborator<\/h2>\n<p>\u00cen cadrul activit\u0103\u021bilor de chimie \u0219i analiz\u0103 a peptidelor, Selank este implicat, printre altele, \u00een urm\u0103toarele domenii de cercetare in vitro:<\/p>\n<ul>\n<li><strong>Cercetarea rela\u021biei structur\u0103-activitate<\/strong> la contribu\u021bia cap\u0103tului Pro-Gly-Pro, unde secven\u021ba extins\u0103 al\u0103turi de motivul tetrapeptidic neextins este caracterizat\u0103 pentru rigiditatea lan\u021bului, profilul de sarcin\u0103 \u0219i comportamentul cromatografic.<\/li>\n<li><strong>Cercetare \u00een chimia peptidelor<\/strong> privind comportamentul lan\u021burilor scurte, bogate \u00een prolin\u0103 \u0219i foarte hidrofile: solubilitate, reten\u021bie \u00een cromatografia cu faz\u0103 invers\u0103 la frac\u021bie organic\u0103 sc\u0103zut\u0103 \u0219i izomerism cis-trans \u00een jurul leg\u0103turii peptidice a prolinei ca surs\u0103 de l\u0103rgire a v\u00e2rfurilor.<\/li>\n<li><strong>Studii de stabilitate enzimatic\u0103<\/strong> \u00een care rata de degradare prin amino- \u0219i carboxipeptidaze este monitorizat\u0103 \u00een sisteme tampon definite, iar fragmentele rezultate sunt atribuite prin spectrometrie de mas\u0103.<\/li>\n<li><strong>Dezvoltarea \u0219i validarea metodelor analitice<\/strong> (HPLC, LC-MS, cartografiere a peptidelor) unde Selank serve\u0219te ca standard de referin\u021b\u0103 pentru secven\u021bele f\u0103r\u0103 cromofor aromatic, cu detec\u021bie pe leg\u0103tura amidic\u0103 \u00een UV \u00eendep\u0103rtat \u0219i cu confirmare a identit\u0103\u021bii prin spectrometrie de mas\u0103.<\/li>\n<\/ul>\n<h2>Specifica\u021bii<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>E\u015fantion<\/strong><\/td>\n<td>Selank<\/td>\n<\/tr>\n<tr>\n<td><strong>Lungimea peptidei<\/strong><\/td>\n<td>7 reziduuri de aminoacizi<\/td>\n<\/tr>\n<tr>\n<td><strong>Secven\u0163\u0103<\/strong><\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRGP)<\/td>\n<\/tr>\n<tr>\n<td><strong>Num\u0103r CAS<\/strong><\/td>\n<td>129954-34-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Formula molecular\u0103 \/ greutate<\/strong><\/td>\n<td>C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \/ circa 751,9 Da<\/td>\n<\/tr>\n<tr>\n<td><strong>Clas\u0103<\/strong><\/td>\n<td>Heptapeptid\u0103 sintetic\u0103 liniar\u0103, bogat\u0103 \u00een prolin\u0103, cu motiv Pro-Gly-Pro C-terminal<\/td>\n<\/tr>\n<tr>\n<td><strong>Form\u0103<\/strong><\/td>\n<td>Pulbere liofilizat\u0103 (pulbere liofilizat\u0103) \u00eentr-un flacon de sticl\u0103 sigilat<\/td>\n<\/tr>\n<tr>\n<td><strong>Puritate<\/strong><\/td>\n<td>\u2265 99% (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Depozitare<\/strong><\/td>\n<td>Liofilizat la 2\u20138 \u00b0C, la loc uscat \u0219i \u00eentunecat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Form\u0103, manipulare \u0219i depozitare<\/h2>\n<p>Materialul este furnizat sub form\u0103 de pulbere liofilizat\u0103 (liofilizat) \u00eentr-un flacon de sticl\u0103 sigilat, cu sept \u0219i capac termocontractabil. Liofilizatul este de culoare alb\u0103 p\u00e2n\u0103 la alb-g\u0103lbuie \u0219i se prezint\u0103 sub form\u0103 de turt\u0103 compact\u0103 sau sub form\u0103 de pulbere fin\u0103; ambele sunt aspecte normale ale procesului de liofilizare. Materialul este higroscopic \u2014 cu at\u00e2t mai mult \u00eentr-o secven\u021b\u0103 bazic\u0103 puternic hidrofil\u0103 \u2014 \u0219i, prin urmare, r\u0103m\u00e2ne \u00eenchis \u00een ambalajul original p\u00e2n\u0103 la procesarea \u00een laborator.<\/p>\n<p>Depozita\u021bi pulberea liofilizat\u0103 nedeschis\u0103 la frigider la 2\u20138 \u00b0C, \u00eentr-un loc uscat \u0219i \u00eentunecat, ferit de lumin\u0103 \u0219i umiditate; pentru perioade mai lungi de depozitare, se p\u0103streaz\u0103 de obicei congelat. L\u0103sa\u021bi flaconul s\u0103 ajung\u0103 la temperatura camerei \u00eenainte de deschidere pentru a minimiza condensul, lucra\u021bi \u00eentr-un mediu curat, utiliza\u021bi echipament individual de protec\u021bie adecvat \u0219i preveni\u021bi contaminarea \u00eencruci\u0219at\u0103 cu alte materiale de laborator. Elimina\u021bi materialul rezidual \u00een conformitate cu instruc\u021biunile de laborator aplicabile.<\/p>\n<h2>Calitate analitic\u0103<\/h2>\n<p>Pentru lan\u021burile scurte, bogate \u00een prolin\u0103, identitatea \u0219i puritatea sunt parametrii determinan\u021bi: lan\u021burile scurtate \u0219i variantele de dele\u021bie difer\u0103 doar u\u0219or \u00een ceea ce prive\u0219te reten\u021bia, iar absen\u021ba unui cromofor aromatic impune cerin\u021be suplimentare de detectare. Selank-ul nostru este furnizat cu o puritate de \u2265 99%, determinat\u0103 prin analiza HPLC \u00een conformitate cu certificatul de analiz\u0103 corespunz\u0103tor. Certificatele de analiz\u0103 disponibile pot fi vizualizate pe site-ul nostru web. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">pagina cu rezultate de laborator<\/a>.<\/p>\n<h2>Declinare de responsabilitate important\u0103<\/h2>\n<p>Furniz\u0103m acest produs strict pentru cercetare de laborator \u0219i lucr\u0103ri analitice. Nu este destinat aplica\u021biilor diagnostice sau terapeutice \u0219i \u00een mod expres nu este destinat utiliz\u0103rii la oameni sau animale. Acest produs nu este un produs alimentar, un supliment, un produs cosmetic sau un produs medicinal \u00eenregistrat. Prin achizi\u021bionarea acestui produs, cump\u0103r\u0103torul confirm\u0103 c\u0103 are 18 ani sau mai mult \u0219i c\u0103 va utiliza produsul exclusiv \u00eentr-un mediu de cercetare sau de laborator controlat.<\/p>","protected":false},"excerpt":{"rendered":"<p>Selank este o heptapeptid\u0103 liniar\u0103 sintetic\u0103 (C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub>, aproximativ 751,9 g\/mol) cu trei reziduuri de prolin\u0103 \u0219i un motiv Pro-Gly-Pro C-terminal care rigidizeaz\u0103 cap\u0103tul lan\u021bului. \u00cen cercetarea \u0219tiin\u021bific\u0103, este studiat ca \u0219i compus model \u00een chimia peptidelor \u0219i \u00een lucr\u0103rile analitice. Destinat exclusiv utiliz\u0103rii \u00een laborator \u0219i cercetare; nu este destinat utiliz\u0103rii la oameni sau animale. Nu este un produs medicinal.<\/p>","protected":false},"featured_media":3232,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,121],"product_tag":[],"class_list":["post-2819","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/comments?post=2819"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2819\/revisions"}],"predecessor-version":[{"id":2893,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2819\/revisions\/2893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media\/3232"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media?parent=2819"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_brand?post=2819"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_cat?post=2819"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_tag?post=2819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}