{"id":2810,"date":"2026-09-01T09:28:24","date_gmt":"2026-09-01T09:28:24","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2810"},"modified":"2026-09-02T09:25:59","modified_gmt":"2026-09-02T09:25:59","slug":"selank-neusspray-kit","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/ro\/product\/selank-neusspray-kit\/","title":{"rendered":"Kit de spray nazal Selank"},"content":{"rendered":"<h2>Ce este Selank?<\/h2>\n<p>Selank este o heptapeptid\u0103 liniar\u0103 sintetic\u0103: un lan\u021b de \u0219apte reziduuri de aminoacizi cu secven\u021ba Thr-Lys-Pro-Arg-Pro-Gly-Pro. Compusul este cunoscut sub num\u0103rul CAS 129954-34-3, cu formula molecular\u0103 C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> (aprox. 751,9 g\/mol) \u0219i PubChem CID 11765600. Primele patru reziduuri (Thr-Lys-Pro-Arg) formeaz\u0103 un fragment tetrapeptidic natural; tripeptida Pro-Gly-Pro este cuplat\u0103 cu acesta la cap\u0103tul C-terminal.<\/p>\n<p>Cu trei reziduuri de prolin\u0103 la \u0219apte pozi\u021bii, Selank este un lan\u021b distinct bogat \u00een prolin\u0103. Secven\u021ba prolin\u0103-glicin\u0103-prolin\u0103 de la cap\u0103tul C-terminal cre\u0219te rigiditatea acelei p\u0103r\u021bi a lan\u021bului \u0219i limiteaz\u0103 atacul exopeptidazelor, f\u0103c\u00e2nd secven\u021ba considerabil mai stabil\u0103 \u00een condi\u021bii de laborator dec\u00e2t fragmentul tetrapeptidic neextins. \u00cen plus, reziduurile de lizin\u0103 \u0219i arginin\u0103 asigur\u0103 un profil de sarcin\u0103 distinct bazic: la pH neutru, molecula poart\u0103 o sarcin\u0103 net\u0103 pozitiv\u0103, care determin\u0103 \u00een mare m\u0103sur\u0103 comportamentul s\u0103u de reten\u021bie \u00een cromatografia \u00een faz\u0103 invers\u0103 cu aditivi de \u00eemperechere a ionilor. Mai mult, lan\u021bul nu con\u021bine reziduuri aromatice, astfel \u00eenc\u00e2t detec\u021bia la 280 nm produce aproape niciun semnal \u0219i este de obicei m\u0103surat\u0103 la puntea peptidic\u0103 \u00een jurul valorii de 214 nm. Aceast\u0103 combina\u021bie \u00eentre o secven\u021b\u0103 scurt\u0103, complet scris\u0103, un cap\u0103t C-terminal rigid \u0219i un profil de sarcin\u0103 bine definit face din Selank un compus model extrem de reproductibil \u00een cercetarea comparativ\u0103 a peptidelor.<\/p>\n<h2>Aplica\u021bii \u00een context de laborator<\/h2>\n<p>\u00cen cadrul activit\u0103\u021bilor de chimie \u0219i analiz\u0103 a peptidelor, Selank este implicat, printre altele, \u00een urm\u0103toarele domenii de cercetare in vitro:<\/p>\n<ul>\n<li><strong>Cercetarea rela\u021biei structur\u0103-activitate<\/strong> la contribu\u021bia motivului Pro-Gly-Pro C-terminal \u0219i a reziduurilor bazice la conforma\u021bia lan\u021bului, distribu\u021bia sarcinii \u0219i comportamentul cromatografic.<\/li>\n<li><strong>Cercetare \u00een chimia peptidelor<\/strong> fa\u021b\u0103 de solubilitatea \u0219i tendin\u021ba de agregare a lan\u021burilor puternic bazice, bogate \u00een prolin\u0103, \u00een medii apoase la pH \u0219i t\u0103rie ionic\u0103 variabile.<\/li>\n<li><strong>Studii de stabilitate enzimatic\u0103<\/strong> \u00een care descompunerea lan\u021bului este monitorizat\u0103 \u00een condi\u021bii definite de pH, temperatur\u0103 \u0219i enzime, iar fragmentele formate sunt caracterizate prin spectrometrie de mas\u0103.<\/li>\n<li><strong>Dezvoltarea \u0219i validarea metodelor analitice<\/strong> (HPLC, LC-MS, cartografiere a peptidelor) unde absen\u021ba reziduurilor aromatice necesit\u0103 detectare la lungimi de und\u0103 joase, iar bazicitatea puternic\u0103 a lan\u021bului necesit\u0103 condi\u021bii de \u00eemperechere a ionilor atent alese.<\/li>\n<\/ul>\n<h2>Specifica\u021bii<\/h2>\n<table>\n<tbody>\n<tr>\n<td><strong>E\u015fantion<\/strong><\/td>\n<td>Selank (heptapeptid\u0103 sintetic\u0103), sub form\u0103 de solu\u021bie peptidic\u0103 \u00eentr-un flacon sigilat<\/td>\n<\/tr>\n<tr>\n<td><strong>Lungimea peptidei<\/strong><\/td>\n<td>7 reziduuri de aminoacizi<\/td>\n<\/tr>\n<tr>\n<td><strong>Secven\u0163\u0103<\/strong><\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro<\/td>\n<\/tr>\n<tr>\n<td><strong>Num\u0103r CAS<\/strong><\/td>\n<td>129954-34-3<\/td>\n<\/tr>\n<tr>\n<td><strong>Formula molecular\u0103 \/ greutate<\/strong><\/td>\n<td>C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub> \/ aproximativ 751,9 g\/mol<\/td>\n<\/tr>\n<tr>\n<td><strong>Clas\u0103<\/strong><\/td>\n<td>Heptapeptid\u0103 liniar\u0103 sintetic\u0103 cu motiv Pro-Gly-Pro C-terminal<\/td>\n<\/tr>\n<tr>\n<td><strong>Form\u0103<\/strong><\/td>\n<td>Solu\u021bie de peptide \u00eentr-o sticl\u0103 sigilat\u0103 cu capac de \u00eenchidere<\/td>\n<\/tr>\n<tr>\n<td><strong>Con\u021binut de peptide<\/strong><\/td>\n<td>10 mg sau 30 mg per flacon<\/td>\n<\/tr>\n<tr>\n<td><strong>Puritate<\/strong><\/td>\n<td>\u2265 99% (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Depozitare<\/strong><\/td>\n<td>Refrigerat la 2\u20138 \u00b0C, \u00eentunecat, \u00eenchis \u0219i \u00een pozi\u021bie vertical\u0103<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Form\u0103, manipulare \u0219i depozitare<\/h2>\n<p>Materialul este furnizat sub form\u0103 de solu\u021bie peptidic\u0103 limpede \u0219i incolor\u0103, \u00eentr-un flacon sigilat cu capac. O solu\u021bie apoas\u0103 este mai sensibil\u0103 la lumin\u0103, c\u0103ldur\u0103 \u0219i schimb\u0103ri repetate de temperatur\u0103 dec\u00e2t o prob\u0103 liofilizat\u0103: lan\u021burile scurte se pot hidroliza lent \u00eentr-un mediu apos, iar pentru un lan\u021b bazic, profilul de sarcin\u0103 se modific\u0103 \u00een plus odat\u0103 cu pH-ul mediului. Prin urmare, flaconul r\u0103m\u00e2ne \u00eenchis \u00een ambalajul original p\u00e2n\u0103 c\u00e2nd proba este procesat\u0103 \u00een laborator.<\/p>\n<p>A se p\u0103stra flaconul la frigider la 2\u20138 \u00b0C, \u00eentr-un loc \u00eentunecat \u0219i \u00een pozi\u021bie vertical\u0103, astfel \u00eenc\u00e2t suprafa\u021ba lichidului s\u0103 nu intre \u00een contact cu \u00eenchiderea. Se aplic\u0103 precau\u021biile obi\u0219nuite de laborator: se lucreaz\u0103 \u00eentr-un mediu curat, se evit\u0103 expunerea prelungit\u0103 la lumin\u0103 \u0219i la temperatura ambiant\u0103 \u0219i se \u00eenregistreaz\u0103 num\u0103rul lotului \u0219i data deschiderii pentru fiecare flacon \u00een jurnalul de laborator, astfel \u00eenc\u00e2t seriile de m\u0103sur\u0103tori s\u0103 r\u0103m\u00e2n\u0103 trasabile ulterior.<\/p>\n<h2>Calitate analitic\u0103<\/h2>\n<p>\u00cen analiza comparativ\u0103 a peptidelor, puritatea materialului de pornire determin\u0103 fiabilitatea interpret\u0103rii rezultatelor m\u0103sur\u0103torilor: variantele de trunchiere, secven\u021bele de dele\u021bie \u0219i fragmentele de degradare produc v\u00e2rfuri cromatografice suplimentare care pot coincide cu componenta principal\u0103, iar \u00een cazul unui lan\u021b c\u0103ruia \u00eei lipse\u0219te un cromofor aromatic, aceast\u0103 verificare necesit\u0103 mult\u0103 munc\u0103. Selank-ul nostru este furnizat cu o puritate de \u2265 99%, determinat\u0103 prin analiz\u0103 HPLC \u00een conformitate cu Certificatul de Analiz\u0103 \u00eenso\u021bitor. Certificatele de Analiz\u0103 disponibile pot fi vizualizate pe site-ul nostru web. <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">pagina cu rezultate de laborator<\/a>.<\/p>\n<h2>Declinare de responsabilitate important\u0103<\/h2>\n<p>Furniz\u0103m acest produs strict pentru cercetare de laborator \u0219i lucr\u0103ri analitice. Nu este destinat aplica\u021biilor diagnostice sau terapeutice \u0219i \u00een mod expres nu este destinat utiliz\u0103rii la oameni sau animale. Acest produs nu este un produs alimentar, un supliment, un produs cosmetic sau un produs medicinal \u00eenregistrat. Prin achizi\u021bionarea acestui produs, cump\u0103r\u0103torul confirm\u0103 c\u0103 are 18 ani sau mai mult \u0219i c\u0103 va utiliza produsul exclusiv \u00eentr-un mediu de cercetare sau de laborator controlat.<\/p>","protected":false},"excerpt":{"rendered":"<p>Selank este o heptapeptid\u0103 liniar\u0103 sintetic\u0103 (C<sub>33<\/sub>H<sub>57<\/sub>N<sub>11<\/sub>O<sub>9<\/sub>, aproximativ 751,9 g\/mol) cu trei reziduuri de prolin\u0103 \u0219i un motiv Pro-Gly-Pro C-terminal care rigidizeaz\u0103 cap\u0103tul lan\u021bului. \u00cen cercetarea \u0219tiin\u021bific\u0103, este studiat ca \u0219i compus model \u00een chimia peptidelor \u0219i \u00een lucr\u0103rile analitice; aceast\u0103 versiune este furnizat\u0103 sub form\u0103 de solu\u021bie peptidic\u0103 \u00eentr-un flacon sigilat. Destinat exclusiv utiliz\u0103rii \u00een laborator \u0219i cercetare; nu este destinat utiliz\u0103rii la oameni sau animale. Nu este un produs medicinal.<\/p>","protected":false},"featured_media":3090,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[133,131],"product_tag":[],"class_list":["post-2810","product","type-product","status-publish","has-post-thumbnail","product_cat-focus-cognitie","product_cat-neussprays","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/comments?post=2810"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2810\/revisions"}],"predecessor-version":[{"id":2890,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2810\/revisions\/2890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media\/3090"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media?parent=2810"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_brand?post=2810"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_cat?post=2810"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_tag?post=2810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}