FOXO4-DRI is a synthetic research peptide, chemically a D-retro-inverso peptide derived from the p53-binding region of the transcription factor FOXO4. Within scientific research, it is studied as a model compound for protein-protein interactions and as a reference standard in analytical work. This compound is offered as a freeze-dried powder of 10 mg per vial, exclusively for laboratory and research purposes.<\/p>\n
FOXO4-DRI, also designated by the development code Proxofim, is a synthetic peptide with the molecular formula C228<\/sub>H388<\/sub>N86<\/sub>O64<\/sub> and a molecular weight of approximately 5,358 Da. The compound is derived from that part of the transcription factor FOXO4 (Forkhead box O4) that provides binding to the protein p53. Characteristic is the D-retro-inverso structure: the amino acid sequence is reversed and all amino acids have been replaced by their mirror-image D-form. As a result, the spatial arrangement of the side chains remains comparable to that of the original L-peptide, while the chain is much less susceptible to degradation by proteases. This combination makes FOXO4-DRI a widely used model in the study of peptidomimetics and stabilized inhibitors of protein-protein interactions.<\/p>\n In research models, FOXO4-DRI is described as an antagonist of the interaction between FOXO4 and p53. In cell models in which cellular senescence has been induced, these two proteins form complexes in the cell nucleus; in vitro, the peptide disrupts this complex formation, after which p53 distributes differently throughout the cell and the intrinsic mitochondrial apoptosis pathway is initiated. Because this is observed selectively in senescent cells in culture systems, rather than in normally dividing cells, the compound is a useful tool for analyzing this selectivity. Consequently, FOXO4-DRI is used as a model compound and reference substance within scientific research.<\/p>\n In a laboratory context, FOXO4-DRI occurs in the following research areas, among others:<\/p>\n Fiecare dintre aceste aplica\u021bii implic\u0103 cercetare controlat\u0103 de laborator sau pe modele preclinice.<\/p>\n FOXO4-DRI falls under the category of freeze-dried research peptides in vial form within our range. Researchers working with this category frequently combine the compound with other peptides studied via their own biochemical target. While FOXO4-DRI focuses on disrupting a specific protein-protein interaction, other components within the same product line have been chosen specifically to cover receptor-bound or enzymatic targets. These compounds share the freeze-dried vial form but differ fundamentally in molecular structure and investigated mechanism.<\/p>\n FOXO4-DRI is supplied as a freeze-dried powder of 10 mg per vial. This lyophilisate is placed in a suitable solvent in a laboratory setup prior to analysis.<\/p>\n A se p\u0103stra flaconul la frigider, ferit de lumina direct\u0103 \u0219i umiditate, \u00een ambalajul original. Manipula\u021bi compusul respect\u00e2nd precau\u021biile standard de laborator: lucra\u021bi \u00eentr-un mediu curat, utiliza\u021bi echipament individual de protec\u021bie adecvat \u0219i preveni\u021bi contaminarea \u00eencruci\u0219at\u0103 cu alte materiale de cercetare. A nu se l\u0103sa la \u00eendem\u00e2na persoanelor neautorizate.<\/p>\n A controlled purity of \u2265 99% (HPLC) is maintained for this lyophilisate. The vial contains the peptide as a dry substance without added excipients.<\/p>\nDomenii de cercetare<\/h2>\n
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FOXO4-DRI in our research range<\/h2>\n
Specifica\u021bii<\/h2>\n
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\n \nSpecifica\u021bii<\/th>\n Valoare<\/th>\n<\/tr>\n<\/thead>\n \n E\u015fantion<\/td>\n FOXO4-DRI<\/td>\n<\/tr>\n \n Sinonime<\/td>\n Proxofim; FOXO4 D-retroinverso peptide<\/td>\n<\/tr>\n \n Formula molecular\u0103 \/ greutate<\/td>\n C228<\/sub>H388<\/sub>N86<\/sub>O64<\/sub> \/ \u2248 5.358 Da<\/td>\n<\/tr>\n \n ID-ul PubChem<\/td>\n 167312269<\/td>\n<\/tr>\n \n Clas\u0103<\/td>\n Synthetic D-retro-inverso peptide; antagonist of the FOXO4\u2013p53 interaction<\/td>\n<\/tr>\n \n Form\u0103<\/td>\n Liofilizat (pulbere liofilizat\u0103)<\/td>\n<\/tr>\n \n Cantitate per flacon<\/td>\n 10 mg<\/td>\n<\/tr>\n \n Num\u0103rul de flacoane per pachet<\/td>\n 1<\/td>\n<\/tr>\n \n Depozitare<\/td>\n A se p\u0103stra la frigider, ferit de lumin\u0103 \u0219i umiditate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Form\u0103, manipulare \u0219i depozitare<\/h2>\n
Compozi\u021bie \u0219i rezultate de laborator<\/h2>\n