{"id":2569,"date":"2026-09-01T09:11:04","date_gmt":"2026-09-01T09:11:04","guid":{"rendered":"https:\/\/pevropeptides.com\/?post_type=product&#038;p=2569"},"modified":"2026-09-02T12:17:40","modified_gmt":"2026-09-02T12:17:40","slug":"pinealon-vial-20-mg","status":"publish","type":"product","link":"https:\/\/pevropeptides.com\/ro\/product\/pinealon-vial-20-mg\/","title":{"rendered":"Flacon cu Pinealon 20 mg"},"content":{"rendered":"<p>Pinealon este o peptid\u0103 scurt\u0103 sintetic\u0103 din grupul bioregulatorilor Khavinson, din punct de vedere chimic o tripeptid\u0103 alc\u0103tuit\u0103 din acid glutamic, acid aspartic \u0219i arginin\u0103. \u00cen cercetarea \u0219tiin\u021bific\u0103 este studiat\u0103 ca un compus model pentru interac\u021biunea peptid\u0103\u2013acid nucleic \u0219i ca standard de referin\u021b\u0103 \u00een activitatea analitic\u0103. Acest compus este oferit sub form\u0103 de pulbere liofilizat\u0103, 20 mg per flacon, exclusiv \u00een scopuri de laborator \u0219i de cercetare.<\/p>\n<h2>What is Pinealon?<\/h2>\n<p>Pinealon (L-alpha-glutamyl-L-alpha-aspartyl-L-arginine, secven\u021ba Glu-Asp-Arg, \u00een literatur\u0103 codul EDR) este o tripeptid\u0103 liniar\u0103 cu formula molecular\u0103 C<sub>15<\/sub>H<sub>26<\/sub>N<sub>6<\/sub>O<sub>8<\/sub> \u0219i o mas\u0103 molecular\u0103 de 418,40 Da. Lan\u021bul combin\u0103 dou\u0103 lan\u021buri laterale acide \u2014 acidul glutamic \u0219i acidul aspartic \u2014 cu arginina puternic bazic\u0103, astfel \u00eenc\u00e2t molecula prezint\u0103 at\u00e2t densitate de sarcin\u0103 negativ\u0103, c\u00e2t \u0219i pozitiv\u0103 pe o distan\u021b\u0103 foarte scurt\u0103. Aceast\u0103 distribu\u021bie a sarcinii \u00een doar trei aminoacizi face din compus un model frecvent utilizat pentru interac\u021biunea dintre peptidele scurte \u0219i biopolimerii \u00eenc\u0103rca\u021bi.<\/p>\n<p>\u00cen modelele de cercetare, Pinealon este studiat ca ligand pentru ADN-ul dublu catenar: spectroscopia \u0219i modelarea molecular\u0103 descriu modul \u00een care peptidele scurte cu aceast\u0103 configura\u021bie de aminoacizi vizeaz\u0103 in vitro secven\u021be nucleotidice specifice din \u0219an\u021bul major al dublei elice. \u00cen modelele celulare se investigheaz\u0103 apoi dac\u0103 o astfel de legare este asociat\u0103 cu modific\u0103ri ale compact\u0103rii cromatinei \u2014 trecerea de la heterocromatina dens compactat\u0103 la eucromatina mai accesibil\u0103 \u2014 \u0219i, astfel, cu transcrierea anumitor gene. Aceast\u0103 ipotez\u0103 de lucru din linia de cercetare Khavinson a fost studiat\u0103 p\u00e2n\u0103 acum mai ales in vitro \u0219i \u00een modele preclinice. \u00cen cercetarea \u0219tiin\u021bific\u0103, Pinealon este a\u0219adar utilizat ca un compus model \u0219i o substan\u021b\u0103 de referin\u021b\u0103.<\/p>\n<h2>Domenii de cercetare<\/h2>\n<p>\u00cen context de laborator, Pinealon apare, printre altele, \u00een urm\u0103toarele domenii de cercetare:<\/p>\n<ul>\n<li>Biophysical research into the binding of short peptides to double-stranded DNA, measured using spectroscopic techniques in vitro.<\/li>\n<li>Molecular modeling studies of the structure-activity relationship of tripeptides with an acid-base charge profile.<\/li>\n<li>Epigenetically oriented modeling of chromatin packing and the accessibility of promoter regions.<\/li>\n<li>Gene expression research in cell culture systems, in which transcript levels are monitored in vitro.<\/li>\n<li>Analytical method development and validation (HPLC, LC-MS) using Pinealon as the reference standard.<\/li>\n<li>Stability and solubility studies of freeze-dried tripeptides under controlled conditions.<\/li>\n<\/ul>\n<p>Fiecare dintre aceste aplica\u021bii implic\u0103 cercetare controlat\u0103 de laborator sau pe modele preclinice.<\/p>\n<h2>Pinealon in our research assortment<\/h2>\n<p>Pinealon falls under the category of freeze-dried peptides in vial form within our range. Researchers in this category regularly combine the compound with other short peptides that are studied via their own biochemical target. While Pinealon focuses on the interaction between a short peptide and nucleic acids, other components in the same product line have been chosen to cover receptor-linked or enzymatic targets. These compounds share the freeze-dried form but differ fundamentally in chain length and investigated mechanism.<\/p>\n<h2>Specifica\u021bii<\/h2>\n<table>\n<thead>\n<tr>\n<th>Specifica\u021bii<\/th>\n<th>Valoare<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>E\u015fantion<\/td>\n<td>Pinealon<\/td>\n<\/tr>\n<tr>\n<td>Sinonime<\/td>\n<td>L-alpha-glutamyl-L-alpha-aspartyl-L-arginine; Glu-Asp-Arg; EDR peptide<\/td>\n<\/tr>\n<tr>\n<td>Num\u0103r CAS<\/td>\n<td>175175-23-2<\/td>\n<\/tr>\n<tr>\n<td>Formula molecular\u0103 \/ greutate<\/td>\n<td>C<sub>15<\/sub>H<sub>26<\/sub>N<sub>6<\/sub>O<sub>8<\/sub> \/ 418.40 Da<\/td>\n<\/tr>\n<tr>\n<td>ID-ul PubChem<\/td>\n<td>10273502<\/td>\n<\/tr>\n<tr>\n<td>Clas\u0103<\/td>\n<td>Tripeptid\u0103 sintetic\u0103, bioregulator peptidic scurt (cytogen)<\/td>\n<\/tr>\n<tr>\n<td>Form\u0103<\/td>\n<td>Liofilizat (pulbere liofilizat\u0103)<\/td>\n<\/tr>\n<tr>\n<td>Cantitate per flacon<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Depozitare<\/td>\n<td>A se p\u0103stra la frigider, ferit de lumin\u0103 \u0219i umiditate<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Form\u0103, manipulare \u0219i depozitare<\/h2>\n<p>Pinealon is supplied as a freeze-dried powder, standardized to 20 mg per vial. Unlike a solid tablet form, a lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work; the dry state serves the stability of the peptide chain during transport and storage.<\/p>\n<p>Store the unopened vial refrigerated, protected from direct light and moisture, in the original packaging; for longer periods, the dry lyophilisate should be stored frozen. Observe the compound with standard laboratory precautions: work in a clean environment, use appropriate personal protective equipment, and prevent cross-contamination with other research materials. Keep the packaging out of reach of unauthorized persons.<\/p>\n<h2>Compozi\u021bie \u0219i rezultate de laborator<\/h2>\n<p>This lyophilisate has a controlled purity of \u2265 99% (HPLC), determined on the peptide chain Glu-Asp-Arg. The vial contains exclusively the freeze-dried peptide.<\/p>\n<p>Pute\u021bi g\u0103si o prezentare general\u0103 a documenta\u021biei analitice disponibile pe site-ul nostru <a href=\"https:\/\/lumopeptides.com\/labresultaten\/\" target=\"_blank\" rel=\"noopener\">pagina cu rezultate de laborator<\/a>Rapoartele sunt colectate centralizat acolo, astfel \u00eenc\u00e2t s\u0103 pute\u021bi \u00eencorpora datele \u00een propriile \u00eenregistr\u0103ri de cercetare.<\/p>\n<h2>\u00centreb\u0103ri frecvente<\/h2>\n<p><strong>To which class of substances does Pinealon belong?<\/strong><br \/>Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg and belongs to the short peptide bioregulators (cytogens) of the Khavinson research line. It is therefore not a small organic molecule, but an amino acid chain.<\/p>\n<p><strong>What is being investigated regarding the DNA interaction of Pinealon?<\/strong><br \/>In vitro studies using spectroscopy and molecular modeling describe how the EDR motif targets specific nucleotide sequences in the major groove of the double helix. In cell models, the question then is whether this binding is associated with looser chromatin packing and altered transcription \u2014 the central focus of mechanistic laboratory research into this connection.<\/p>\n<p><strong>Sub ce form\u0103 este furnizat compusul?<\/strong><br \/>As a freeze-dried powder of 20 mg per vial. A lyophilisate is dissolved in a suitable solvent prior to analytical or cell culture work.<\/p>\n<p><strong>How do I store the bottle?<\/strong><br \/>Refrigerated, protected from light and moisture, preferably in the original packaging.<\/p>","protected":false},"excerpt":{"rendered":"<p>Pinealon este un bioregulator tripeptidic sintetic din linia de cercetare Khavinson (familia cytogen). \u00cen cercetare, Pinealon este studiat \u00een modele referitoare la neuroni \u0219i func\u021bia cerebral\u0103.<\/p>","protected":false},"featured_media":3255,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[122,120,121],"product_tag":[],"class_list":["post-2569","product","type-product","status-publish","has-post-thumbnail","product_cat-cognitief","product_cat-longevity-onderzoek","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/comments?post=2569"}],"version-history":[{"count":1,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2569\/revisions"}],"predecessor-version":[{"id":2646,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product\/2569\/revisions\/2646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media\/3255"}],"wp:attachment":[{"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/media?parent=2569"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_brand?post=2569"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_cat?post=2569"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pevropeptides.com\/ro\/wp-json\/wp\/v2\/product_tag?post=2569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}